Corynebacterium acnes From Human Skin

Ray, Leon F.

doi:10.1001/archderm.1970.04000010038005

Cited by 24 publications

(4 citation statements)

References 11 publications

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“…Propionibacterium acnes is an anaerobic gram positive non‐sporing bacillus that forms a major component of the human skin flora 1. On first isolation it often takes between 1 and 3 weeks to grow.…”

Section: Introductionmentioning

confidence: 99%

Biofilm formation by Propionibacterium acnes on biomaterials in vitro and in vivo: Impact on diagnosis and treatment

Bayston

Ashraf

Barker-Davies

et al. 2006

J Biomedical Materials Res

107

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Propionibacterium acnes is found increasingly as a cause of delayed infection, usually involving implanted biomaterials. Despite susceptibility to common antibiotics, such infections are very difficult to treat and usually require surgical removal of the device. Three clinical isolates of P. acnes were assessed for ability to adhere to titanium, surgical steel and silicone, with and without a plasma conditioning film. After adherence, the biomaterials were then incubated for a further 6 days and examined for biofilm development. All three isolates adhered to all three biomaterials similarly. Importantly, we were able to demonstrate biofilm formation, including production of exopolymer similar in appearance to the polysaccharide intercellular adhesin of Staphylococcus epidermidis. A case summary also demonstrated failure to eradicate P. acnes infection in a hydrocephalus shunt after prolonged treatment. The removed shunt showed obvious biofilm formation, initially obscured by exopolymer when viewed by environmental scanning electron microscopy. Biofilm development by P. acnes explains the difficulties encountered in clinical management of such infections.

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Section: Introductionmentioning

confidence: 99%

Biofilm formation by Propionibacterium acnes on biomaterials in vitro and in vivo: Impact on diagnosis and treatment

Bayston

Ashraf

Barker-Davies

et al. 2006

J Biomedical Materials Res

107

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“…Propionibacterium acnes is a Gram‐positive, non‐spore‐forming, anaerobic rod that is a common inhabitant of the skin, anterior nares, conjunctiva, mouth, and upper respiratory tract [1,2]. It is a common contaminant of cultures obtained percutaneously (surgical wound swabs, blood or other body fluids).…”

mentioning

confidence: 99%

“…Foreign bodies and previous surgery play important roles in the pathogenesis of infection due to P. acnes , as shown in this report. The high concentrations of P. acnes in the sebaceous glands of the scalp and forehead make neurologic sites a target for its pathogenic potential [2]. Perhaps for this reason, in 26 of 44 cases (59.1%) the infection had been detected in a neurologic setting.…”

mentioning

confidence: 99%

Clinical spectrum of infections due to Propionibacterium acnes

Esteban

Ramos

Soriano

1998

Clinical Microbiology and Infection

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“…Slide agglutination tests have been used by a number of investigators (e.g., 12) for the identification of P. acnes (C. acnes), especially since antisera are commercially available. However, a number of strains may be autoagglutinable, which makes the method unreliable.…”

mentioning

confidence: 99%

Identification of Propionibacterium acnes and Related Organisms by Precipitin Tests with Trichloroacetic Acid Extracts

Cummins

1975

J Clin Microbiol

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The serological identification of Propionibacterium acnes, P. granulosum , and P. avidum , using trichloroacetic acid extracts, is described. With antisera prepared against reference strains, the method has been tested on 142 strains recently isolated from human skin. All except two of the strains could be identified serologically, and there was excellent agreement between the serological results and the fermentation pattern of the strains. Two serological types of P. acnes and two of P. avidum were identified, but only one of P. granulosum.

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Corynebacterium acnes From Human Skin

Cited by 24 publications

References 11 publications

Biofilm formation by Propionibacterium acnes on biomaterials in vitro and in vivo: Impact on diagnosis and treatment

Biofilm formation by Propionibacterium acnes on biomaterials in vitro and in vivo: Impact on diagnosis and treatment

Clinical spectrum of infections due to Propionibacterium acnes

Identification of Propionibacterium acnes and Related Organisms by Precipitin Tests with Trichloroacetic Acid Extracts

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