Corynebacterium accolens Has Antimicrobial Activity against Staphylococcus aureus and Methicillin-Resistant S. aureus Pathogens Isolated from the Sinonasal Niche of Chronic Rhinosinusitis Patients

Menberu, Martha Alemayehu; Li, Sha; Cooksley, Clare; Hayes, Andrew; Psaltis, Alkis James; Wormald, Peter‐John; Vreugde, Sarah

doi:10.3390/pathogens10020207

Cited by 38 publications

(40 citation statements)

References 38 publications

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“…accolens incidence was significantly decreased in the URT of patients with SARS-CoV-2 compared with uninfected controls ( Mostafa et al., 2020 ). Corynebacterium accolens can inhibit Streptococcus pneumoniae and Staphylococcus aureus growth, possibly through triolein hydrolysis, which releases oleic acid ( Bomar et al., 2016 ; Menberu et al., 2021 ). In addition to inhibiting bacterial pathogens, oleic acid is capable of inhibiting other enveloped viruses, such as herpes and influenza ( Kohn et al., 1980 ).…”

Section: Discussionmentioning

confidence: 99%

Severe COVID-19 Is Associated With an Altered Upper Respiratory Tract Microbiome

Shilts

Rosas‐Salazar

Strickland

et al. 2022

Front. Cell. Infect. Microbiol.

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BackgroundThe upper respiratory tract (URT) is the portal of entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and SARS-CoV-2 likely interacts with the URT microbiome. However, understanding of the associations between the URT microbiome and the severity of coronavirus disease 2019 (COVID-19) is still limited.ObjectiveOur primary objective was to identify URT microbiome signature/s that consistently changed over a spectrum of COVID-19 severity.MethodsUsing data from 103 adult participants from two cities in the United States, we compared the bacterial load and the URT microbiome between five groups: 20 asymptomatic SARS-CoV-2-negative participants, 27 participants with mild COVID-19, 28 participants with moderate COVID-19, 15 hospitalized patients with severe COVID-19, and 13 hospitalized patients in the ICU with very severe COVID-19.ResultsURT bacterial load, bacterial richness, and within-group microbiome composition dissimilarity consistently increased as COVID-19 severity increased, while the relative abundance of an amplicon sequence variant (ASV), Corynebacterium_unclassified.ASV0002, consistently decreased as COVID-19 severity increased.ConclusionsWe observed that the URT microbiome composition significantly changed as COVID-19 severity increased. The URT microbiome could potentially predict which patients may be more likely to progress to severe disease or be modified to decrease severity. However, further research in additional longitudinal cohorts is needed to better understand how the microbiome affects COVID-19 severity.

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Section: Discussionmentioning

confidence: 99%

Severe COVID-19 Is Associated With an Altered Upper Respiratory Tract Microbiome

Shilts

Rosas‐Salazar

Strickland

et al. 2022

Front. Cell. Infect. Microbiol.

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“…While the exact shift in Corynebacterium population during AD disease course is still unknown, several studies have identified the ability of Corynebacterium spp including striatum, pseudodiphtheriticum and accolens to inhibit SA growth and virulence. [94][95][96] The precise inhibitory Commensals Anti-Staphylococcus aureus mechanism Reference…”

Section: S Epidermidis Has Been Shownmentioning

confidence: 99%

Updated understanding of Staphylococcus aureus in atopic dermatitis: From virulence factors to commensals and clonal complexes

Hwang

Thompson

Jaros

et al. 2021

Experimental Dermatology

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Atopic dermatitis (AD) is an inflammatory dermatosis with a pathogenesis believed to be due to a combination of genetic, immunologic and environmental factors that affects up to 5% of adults and 20% of children worldwide. 1,2 Common genetic factors include polymorphisms in the filaggrin structural protein, interleukin (IL)-4 receptor and vitamin D receptor. [3][4][5] AD is driven by multiple immune pathways, most commonly with activation of Th2 and Th22 T-cell subsets. 6 Crosstalk between commensals and the host immune system modulates adaptive and innate immune responses in AD. 7 Staphylococcus aureus (SA) in AD lesions and surrounding normal skin was first noted by Leyden et al. in the 1970s; since then, the understanding of its role in AD has drastically evolved. 8,9 SA is a well-established exacerbator of AD; it is frequently isolated from the skin of AD patients and increased SA density is found during flares. 10 A meta-analysis in 2016 reported a pooled prevalence of SA colonization among AD patients of 70% in lesional skin, 39% in non-lesional skin and 62% in the nose. 11 More recently, Kong et al 12 found that AD treatments and flares were closely associated with shifts in the cutaneous microbial diversity. While current evidence has established that SA proliferates during flares and plays a role in the cycle of epidermal breakdown and inflammation, a true causal relationship has not been established. Herein, we will summarize the

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“…to inhibit the growth and colonization of pathobionts in the respiratory tract. C. accolens can inhibit S. pneumoniae via liberation of free fatty acids from triacylglycerols found on the skin (Bomar et al, 2016), and clinical isolates of C. accolens can inhibit the growth of methicillin resistant S. aureus (Menberu et al, 2021). C. pseudodiphtheriticum is inhibitory against M. catarrhalis and S. aureus (Hardy et al, 2019;Lappan, 2019).…”

Section: Dolosigranulum Pigrum and Corynebacterium Sppmentioning

confidence: 99%

Manipulation of the Upper Respiratory Microbiota to Reduce Incidence and Severity of Upper Respiratory Viral Infections: A Literature Review

2021

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There is a high incidence of upper respiratory viral infections in the human population, with infection severity being unique to each individual. Upper respiratory viruses have been associated previously with secondary bacterial infection, however, several cross-sectional studies analyzed in the literature indicate that an inverse relationship can also occur. Pathobiont abundance and/or bacterial dysbiosis can impair epithelial integrity and predispose an individual to viral infection. In this review we describe common commensal microorganisms that have the capacity to reduce the abundance of pathobionts and maintain bacterial symbiosis in the upper respiratory tract and discuss the potential and limitations of localized probiotic formulations of commensal bacteria to reduce the incidence and severity of viral infections.

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Corynebacterium accolens Has Antimicrobial Activity against Staphylococcus aureus and Methicillin-Resistant S. aureus Pathogens Isolated from the Sinonasal Niche of Chronic Rhinosinusitis Patients

Cited by 38 publications

References 38 publications

Severe COVID-19 Is Associated With an Altered Upper Respiratory Tract Microbiome

Severe COVID-19 Is Associated With an Altered Upper Respiratory Tract Microbiome

Updated understanding of Staphylococcus aureus in atopic dermatitis: From virulence factors to commensals and clonal complexes

Manipulation of the Upper Respiratory Microbiota to Reduce Incidence and Severity of Upper Respiratory Viral Infections: A Literature Review

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