Cortistatin hyperpolarizes pancreatic beta cell membrane and reduces glucose-stimulated insulin secretion

Transcriptome analysis in blood cells from children reveals potential early biomarkers of metabolic alterations

“…CORT has been shown to bind with high affinity to the ghrelin receptor (GHSR) and play important actions on pancreatic function (41). In islets isolated from C57BL6 mice, CORT action has been reported to reduce the glucose-stimulated insulin secretion (42). Therefore, the presence of higher expression levels of this gene in PBCs from overweight children may also be in agreement with a greater predisposition to type 2 diabetes.…”