Cortisone, Acth and Antibiotics in Fulminant Hepatitis

Ducci, H; Katz, R

doi:10.1016/s0016-5085(52)80035-6

Cited by 83 publications

(15 citation statements)

References 11 publications

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“…Systemically active conventional corticosteroids have played a significant role in the induction of remission in autoimmune liver diseases, liver transplantation, and virus induced hepatitis (Ducci and Katz, 1952; Czaja et al, 1984; Fujiwara et al, 2010). Recent study by Varga et al (Varga et al, 2008) suggested that the GC treatment might induce an activated, anti-inflammatory monocyte subset in mice that resembles myeloid-derived suppressor cells.…”

Section: Resultsmentioning

confidence: 99%

The protective role of myeloid-derived suppressor cells in concanavalin A-induced hepatic injury

et al. 2014

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The mechanism underlying T cell-mediated fulminant hepatitis is not fully understood. In this study, we investigated whether myeloid derived suppressor cells (MDSCs) could prevent the concanavalin A (ConA)-induced hepatitis through suppressing T cell proliferation. We observed an increase in the frequencies of MDSCs in mouse spleen and liver at early stage of ConA treatment, implicating that the MDSCs might be involved in the initial resistance of mice against ConA-mediated inflammation. Subpopulation analysis showed that the MDSCs in liver of ConA-induced mice were mainly granulocytic MDSCs. Adoptive transfer of the bone marrow-derived MDSCs into ConA-treated mice showed that the MDSCs migrated into the liver and spleen where they suppressed T cell proliferation through ROS pathway. In addition, the frequencies of MDSCs in mice were also significantly increased by the treatment with immune suppressor glucocorticoids. Transfer of MDSCs into the regulatory T cell (Treg)-depleted mice showed that the protective effect of MDSCs on ConA-induced hepatitis is Treg-independent. In conclusion, our results demonstrate that MDSCs possess a direct protective role in T cell-mediated hepatitis, and increasing the frequency of MDSCs by either adoptive transfer or glucocorticoid treatment represents a potential cell-based therapeutic strategy for the acute inflammatory disease.

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Section: Resultsmentioning

confidence: 99%

The protective role of myeloid-derived suppressor cells in concanavalin A-induced hepatic injury

et al. 2014

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“…In the many published series of hepatic coma and of viral hepatitis sudden unconsciousness is rarely mentioned as a manifestation even in cases which eventually proved fatal. Several authors (Lucke, 1944;Stokes et al, 1945 ;Sodeman, 1946;Murphy et al, 1948;Walshe, 1951 ;Ducci and Katz, 1952) stress the constant sequence from lethargy to noisy confusion, and only terminally the onset of coma, in fulminant hepatitis.…”

Section: Discussionmentioning

confidence: 99%

Serum Hepatitis Presenting as Sudden Loss of Consciousness

Bennett¹,

Hoff²

1965

BMJ

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Erythropoietin in Urine-Finne MEDICAL JOURNAL 699 will give a better idea of the degree of humoral stimulation of erythropoiesis than measuring the plasma erythropoietin level.When we want to compare from one laboratory to another the amount of erythropoietin found in the urine in different diseases, the method of concentration must be taken into consideration. The simple way of concentration by freezedrying after dialysis must be regarded as less destructive than precipitation or boiling. With these last methods a loss of erythropoietin may be suspected during the different procedures, although the end-product may be a more concentrated and pure one. However, so long as the only means of assaying the erythropoietin is by its biological activity and not by chemical quantitation, the easy way of concentration by dialysis and freeze-drying is most suitable for the purpose of quantitating urinary erythropoietin excretion.As the amount of erythropoietin excreted under physiological conditions is as high as is shown in Table II, the discrimination between persons with different levels of erythropoietin excretion would be easier if the concentrates were divided in smaller doses than used in the present study-that is, injected into a greater number of mice-because the maximum response to erythropoietin is obtained with about 6-8 units per mouse (DeGowin et al., 1962). The contrary would be the case in persons with lowered erythropoietin excretion.When measuring the amount of erythropoietin excreted in the urine the sensitivity of the assay method should be shown by a calibration curve using "standard erythropoietin." In this way the 24-hour erythropoietin excretion could be given in "standard units."The demonstration of erythropoietin in normal amniotic fluid must be taken to be in favour of the hypothesis that erythropoiesis is regulated through erythropoietin antenatally as well. It is also likely that erythropoietin in the amniotic fluid is derived from the urine, since previous investigations have shown that in anaemic foetuses erythropoietin may be excreted in the urine (Finne, 1964

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“…Polyvitamin therapy (Latner, 1950), large doses of liver extract (Snell and Butt, 1941), glutamic acid (Walshe, 1953), and cortisone (Ducci and Katz, 1952) have all been advocated forwidely differing reasons in the treatment of hepatic failure. Though these measures may sometimes be followed by symptomatic improvement, claims that they increase the patient's chances of survival should be examined critically.…”

Section: Discussionmentioning

confidence: 99%

Surgical Emphysema as a Complication of Anaesthesia

Ozinsky¹,

Bull²

1955

BMJ

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Experiment Ill: Sodium Gluconate.-Of 28 rats fed on stock diet and subjected to the injection of carbon tetrachloride into the mesenteric vein, half were given 50 mg. of the monosodium salt of glutamic acid eight-hourly by subcutaneous injection for 48 hours after operation.Experiment IV: Cortisone.-Of 40 rats fed on stock diet and subjected to injection of carbon tetrachloride into the mesenteric vein, 20 were given 2 mg. of cortisone per 100 g. body weight twice a day by intramuscular injection for two days after operation.

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Cortisone, Acth and Antibiotics in Fulminant Hepatitis

Cited by 83 publications

References 11 publications

The protective role of myeloid-derived suppressor cells in concanavalin A-induced hepatic injury

The protective role of myeloid-derived suppressor cells in concanavalin A-induced hepatic injury

Serum Hepatitis Presenting as Sudden Loss of Consciousness

Surgical Emphysema as a Complication of Anaesthesia

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