Cortisol Sensitizes Cochlear Hair Cells to Gentamicin Ototoxicity Via Endogenous Apoptotic Pathway
Cong Li,
Liang Chen,
Yingying Li
et al.
Abstract:Hypothesis
The stress hormone cortisol affects aminoglycoside-induced ototoxicity.
Background
The widespread use of aminoglycosides is a prevalent cause of sensorineural hearing loss. Patients receiving aminoglycosides usually have elevated levels of circulating stress hormones due to disease or physiological stress; however, whether the stress hormone cortisol impacts aminoglycoside-mediated injury of cochlear hair cells has not been fully investigated.
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