Cortisol response to stress as a predictor for suicidal ideation in youth

Shalev, Amit; Porta, Giovanna; Biernesser, Candice; Zelazny, Jamie; Walker-Payne, Monica; Melhem, Nadine M.; Brent, David A.

doi:10.1016/j.jad.2019.06.053

Cited by 22 publications

(14 citation statements)

References 43 publications

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Section: Resultsmentioning

confidence: 94%

“…These authors reported that patients with brief periods of suicidal ideation exhibited greater cortisol response compared to those with longer/continuous ideation [43]. Shalev and colleagues [44] confirmed that the persistence of SI was associated with higher cortisol reactivity to stress, and that higher baseline cortisol levels may predict future SI (Table 2). O'Connor et al [45] investigated whether cortisol reactivity to the Maastricht Acute Stress Test (MAST) differs between patients with a previous suicide attempt, suicide ideators, and a control group.…”

Section: The Trier Social Stress Test and (Tssta) And Maastricht Acutmentioning

confidence: 95%

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The Involvement of Hypothalamus–Pituitary–Adrenal (HPA) Axis in Suicide Risk

et al. 2020

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Stress and Hypothalamic–Pituitary–Adrenal (HPA) axis dysregulation play a major role in various pathophysiological processes associated with both mood disorders and suicidal behavior. We conducted a systematic review with the primary aim of clarifying the nature and extent of HPA axis activity and suicidal behavior. The second aim of this review was to investigate whether potential biomarkers related to HPA axis abnormalities act as individual susceptibility factors for suicide. The PRISMA statement for reporting systematic reviews was used. Only articles published in English peer-reviewed journals were considered for possible inclusion; we excluded case reports, meta-analyses, and systematic reviews, and studies that did not clearly report statistical analysis, diagnostic criteria, or the number of patients included. Overall, 36 articles on HPA axis and suicide risk met inclusion criteria and were reviewed. Studies that investigated tests detecting biomarkers and the role of early life stressors in suicide risk were also included. We found that HPA axis activity is involved in suicide risk, regardless of the presence or absence of psychiatric conditions. The HPA axis abnormalities, mainly characterized by hyperactivity of the HPA axis, may exert an important modulatory influence on suicide risk. Impaired stress response mechanisms contribute to suicide risk. Targeting HPA axis dysregulation might represent a fruitful strategy for identifying new treatment targets and improving suicide risk prediction.

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Section: Resultsmentioning

confidence: 94%

Section: The Trier Social Stress Test and (Tssta) And Maastricht Acutmentioning

confidence: 95%

The Involvement of Hypothalamus–Pituitary–Adrenal (HPA) Axis in Suicide Risk

et al. 2020

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“…First, childhood maltreatment could disturb the hypothalamic-pituitary-adrenal axis. It has been found that adult women with childhood abuse experience had higher plasma cortisol levels than non-abused individuals, and elevated cortisol is an identified risk factor for future SI (Shalev et al, 2019). Second, childhood maltreatment impairs cognitive function (Miller & Esposito-Smythers, 2013), and it has been repeatedly verified that cognitive impairment is directly associated with SI (Pu, Setoyama & Noda, 2017).…”

Section: Discussionmentioning

confidence: 99%

Childhood maltreatment and suicidal ideation in Chinese children and adolescents: the mediation of resilience

Xue

Jiang

Liu

et al. 2021

PeerJ

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Background Childhood maltreatment could increase the risk of suicidal ideation (SI) in adolescents. However, the mediation of resilience in this association remains unclear. Methods A population-based cross-sectional study has been done among 3,146 Chinese adolescents. We collected relevant information from the study participants by using self-administered questionnaire. Chinese version of the Childhood Trauma Questionnaire (CTQ), the Resilience Scale for Chinese Adolescents (RSCA), and the Beck Scale for Suicide Ideation (BSSI) were used to measure childhood maltreatment, resilience, and SI, respectively. Univariate and multivariate binary Logistic regression models were employed to estimate crude and adjusted associations between childhood maltreatment, resilience, and SI. Path analysis has subsequently been performed to measure the mediation of resilience in this association. Results Multivariate Logistic regression models revealed that compared to non-abused counterparts, adolescents who had ever experienced any type of childhood maltreatment was 1.74 times likely to report SI. Among the specific types of childhood maltreatment, emotional abuse showed the strongest association with SI (adjusted OR = 3.01, 95% CI [2.37–3.82]). Path model suggested that over one-third (39.8%) of the total association between childhood maltreatment and SI was mediated via resilience. Emotion regulation and interpersonal assistance were the most prominent mediators among all dimensions of resilience. Conclusions Resilience played as a significant mediator in the association between childhood maltreatment and SI. Resilience-oriented intervention measures could be considered for suicidal risk prevention among abused Chinese adolescents.

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“…Además, los factores biológicos indican que la IS se encuentra asociada a la disminución de la ac vidad funcional de la corteza prefrontal ventromedial, vinculada a la impulsividad y planificación de riesgo suicida (Echeverry et al, 2010) y bajo nivel de serotonina (Gu érrez-García & Contreras, 2008). Inclusive, el aumento del cor sol puede predecir la IS (Shalev et al, 2019).…”

Section: Ideación Suicida;unclassified