Cortisol Response to Dexamethasone in Women with Premenstrual Syndrome

Roy‐Byrne, Peter; Rubinow, David R.; Gwirtsman, Harry E.; Hoban, M.Christine

doi:10.1159/000118298

Cited by 30 publications

(10 citation statements)

References 5 publications

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“…This observation, in the face of an opposing circadian influence, combined with the results from other studies documenting diminished HPA-axis activation in PMDD (33,34,(35)(36)(37), suggests that blunted HPA-axis function may be a robust characteristic of PMDD. We also observed that only for PMDD women did the menstrual cycle exert an effect on basal NE levels, resulting in PMDD women having greater NE levels than controls during the luteal, symptomatic phase only.…”

Section: S S Girdler Et Alsupporting

confidence: 58%

Biological Correlates of Abuse in Women with Premenstrual Dysphoric Disorder and Healthy Controls

Girdler

Sherwood²,

Hinderliter

et al. 2003

Psychosomatic Medicine

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Section: S S Girdler Et Alsupporting

confidence: 58%

Biological Correlates of Abuse in Women with Premenstrual Dysphoric Disorder and Healthy Controls

Girdler

Sherwood²,

Hinderliter

et al. 2003

Psychosomatic Medicine

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“…However, neither our study nor more detailed evaluations of circadian rhythmicity (17,18) have found major abnormalities in cortisol plasma levels in PMS patients. In addition, adequate suppression after dexamethasone administration represents an additional finding in favor of a normal cortisol regulation in PMS patients (19).…”

Section: Discussionmentioning

confidence: 99%

Changes of opioid modulation of the hypothalamo-pituitary-adrenal axis in patients with severe premenstrual syndrome.

Facchinetti

Fioroni

Martignoni

et al. 1994

Psychosomatic Medicine

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To assess the function of the hypothalamus-pituitary-adrenal axis in patients with severe premenstrual syndrome (PMS) 28 patients and 14 asymptomatic controls were studied during the mid-to late-luteal phase of the menstrual cycle. The response of plasma cortisol to both high-dose naloxone and corticotropinreleasing hormone (CRH) was assessed. Naloxone stimulated a significant cortisol release in controls whereas it was otherwise almost absent in patients. CRH stimulated a greater release of cortisol in patients than in controls. Fifteen patients met criteria for either current anxiety and/or mood disorders. The cortisol secretion after both naloxone and CRH stimulations was similar for PMS patients with or without psychiatric disorders. These data indicate that endogenous opioids modulate the activity of the hypothalamus-pituitary-adrenal axis. Irrespective of the concomitant presence of menstrual migraine or psychiatric disorder, such control is altered in patients with severe PMS because of the possible hyposensitivity of opiate receptors. The hyperresponsiveness to CRH may be the consequence of the reduced inhibition that endogenous opioids tonically exert on HPA axis.

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“…They found normal levels of 24 h urinary free cortisol during both follicular and luteal phases of the cycle (Haskett et al 1984) and no evidence of increased resistance to dexamethasone suppression (Haskett et al 1984;Roy-Byrne et al 1986). They found normal levels of 24 h urinary free cortisol during both follicular and luteal phases of the cycle (Haskett et al 1984) and no evidence of increased resistance to dexamethasone suppression (Haskett et al 1984;Roy-Byrne et al 1986).…”

Section: (Ii) Neurotransmitter Receptor Levels In the Peripheral Bloodmentioning

confidence: 99%

The premenstrual syndrome – a reappraisal of the concept and the evidence

Bancroft¹

1993

Psychol. Med. Monogr. Suppl.

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Request Permissions : Click here Downloaded from http://journals.cambridge.org/PMS, IP address: 216.165.126.139 on 12 Apr 2015 SYNOPSIS The Premenstrual Syndrome (PMS) remains a controversial issue. As a clinical concept it is surrounded by confusion. Attempts to establish a consensus definition have resulted in the majority of women seeking help for such problems excluded from the diagnosis. Furthermore, there is no consensus about how such problems should be treated, with a variety of methods being advocated usually on very uncertain scientific grounds. The issue also has its political implications; there are those who see PMS as a way of reducing the status of women, by linking the normal ovarian cycle to a phenomenon which, on the face of it, impairs women's ability to cope. Yet there are a substantial number of women who experience significant negative changes which vary with the menstrual cycle, and produce long-term effects on their well being and family relationship which can be serious. There is also a real possibility that recurrent perimenstrual mood changes of this kind may increase the likelihood of chronic depressive illness in susceptible individuals. In most respects the features of depression which occurs perimenstrually are essentially similar to those of major depressive disorder, except for the short duration and recurrent pattern.PMS, therefore, remains an issue not only of clinical importance, but of considerable potential relevance to our understanding of major depressive disorder, which is substantially more common in women of reproductive age than in their male counterparts.In this review the concept of PMS, and some prominent operational definitions of it, are critically evaluated; it is now questionable whether the concept, as currently applied, still carries any heuristic or clinical value. Some current theoretical and aetiological issues are considered: e.g. the role of the corpus luteum, the effects of hormonal regimes which block ovulation, such as oral contraceptives, and the possibility that cyclical mood change represents an entrained rhythm in the brain.The conclusions reached at this stage in the review lead to a ' paradigm shift' with the proposal of a three-factor model to account for the complexities of menstrual cycle-related problems. These three factors are (a) the 'timing factor', imposed by the ovarian hormonal cycle, and possibly accounting for cyclical changes in CNS neurotransmitter activity; (b) a 'menstruation factor', including the processes involved in the build up as well as shedding of the endometrium and the ways in which these processes might adversely affect the women's well being both premenstrually as well as during menstruation; and (c) the 'vulnerability factor', covering a variety of characteristics, constitutional as well as situational, psychosocial as well as biological, which are not in themselves functions of the menstrual cycle but which serve to determine how vulnerable a woman will be to the first two factors.The relevant evidence in the litera...

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Cortisol Response to Dexamethasone in Women with Premenstrual Syndrome

Cited by 30 publications

References 5 publications

Biological Correlates of Abuse in Women with Premenstrual Dysphoric Disorder and Healthy Controls

Biological Correlates of Abuse in Women with Premenstrual Dysphoric Disorder and Healthy Controls

Changes of opioid modulation of the hypothalamo-pituitary-adrenal axis in patients with severe premenstrual syndrome.

The premenstrual syndrome – a reappraisal of the concept and the evidence

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