Cortisol reactivity to stress among youth: Stability over time and genetic variants for stress sensitivity.

Hankin, Benjamin L.; Badanes, Lisa S.; Smolen, Andrew; Young, Jami F.

doi:10.1037/abn0000030

Cited by 47 publications

(45 citation statements)

References 108 publications

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“…Parents’ depression and various aspects of child temperament predicted longitudinal cortisol reactivity in middle childhood (44). Cortisol reactivity exhibits moderate trait-like stability over time, and particular genetic variants for stress susceptibility, especially 5- HTTLPR and CRHR1 , predict greater cortisol stability (45). Also consistent with this review’s emphasis on integrating risk across multiple systems and levels of analysis, parental depression history and child cognitive vulnerability interacted to predict cortisol reactivity (46).…”

Section: Biological Stress Processesmentioning

confidence: 99%

Depression from childhood through adolescence: risk mechanisms across multiple systems and levels of analysis

Hankin

2015

Current Opinion in Psychology

110

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This paper selectively reviews recent research, especially in the last two years (2012-2014) in preschool, child, and adolescent depression. In particular, attention is paid to developmental epidemiology as well as risk factors and processes that contribute to depression trajectories over time. Emphasis is placed on a developmental psychopathology perspective in which risks are instantiated across multiple systems and levels of analysis, including genetics, stress contexts and processes, biological stress mechanisms, temperament, emotion, reward, cognitive factors and processes, and interpersonal influences. These risks dynamically transact over time, as they emerge and stabilize into relatively trait-like vulnerabilities that confer risk for the increasing rates of depression observed in adolescence. Overall, this summary illustrates that considerable progress has been made recently in understanding the complex developmental processes contributing to depression. Finally, a few gaps are highlighted as opportunities for future research.

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Section: Biological Stress Processesmentioning

confidence: 99%

Depression from childhood through adolescence: risk mechanisms across multiple systems and levels of analysis

Hankin

2015

Current Opinion in Psychology

110

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“…Yet, they both play a crucial role in developing cognitive skills such as analytical thought and long-term planning strategies which may help the individual in creating a more benign environment in later life (Ehlert, 2013;Teicher et al, 2003).The impact of stress as experienced in the context of childhood trauma depends on the level of stress-sensitivity of an individual. Stress-sensitivity differs markedly between individuals, and genetic factors explain part of the variance found in sensitivity to stress (Hankin, Badanes, Smolen, & Young, 2015;Jang, Taylor, Stein, & Yamagata, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…Stress-sensitivity manifests itself in higher stress-reactivity in adult life (Ehlert, 2013;Glaser, van Os, Portegijs, & MyinGermeys, 2006;Hulme, 2011;Jang et al, 2007). Childhood trauma was found to be associated with stress-sensitivity in the general population, as well as in people at high risk for developing psychotic disorders (Ehlert, 2013;Hankin et al, 2015;Hulme, 2011;Jang et al, 2007;Javier, 2012;Loewy, 2012;Loewy et al, 2014;Teicher et al, 2003). The personality traits neuroticism (van Os et al, 2001) and openness to experience have been linked to tendencies towards stress-reactivity (Headey & Wearing, 1989;Komulainen et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

The effect of childhood trauma and Five-Factor Model personality traits on exposure to adult life events in patients with psychotic disorders

Pos¹,

Boyette

Meijer³

et al. 2016

Cognitive Neuropsychiatry

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Introduction: Recent life events are associated with transition to and outcome in psychosis. Childhood trauma and personality characteristics play a role in proneness to adult life events. However, little is known about the relative contribution and interrelatedness of these characteristics in psychotic disorders. Therefore, we investigated whether Five-Factor Model (FFM) personality traits and childhood trauma (abuse and neglect) predict adult life events, and whether the effect of childhood trauma on life events is mediated by personality traits. Method: One hundred and sixty-three patients with psychotic disorders were assessed at baseline on history of childhood maltreatment and FFM personality traits, and on recent life events at 3-year follow-up. Results: Childhood abuse is associated with negative life events, and part of the effect of childhood abuse on negative life events is mediated by openness to experience. Openness to experience and extraversion are associated with more positive and negative life events. Childhood neglect and lower extraversion are related to experiencing less positive events. Conclusion: The association between childhood trauma and recent life events is partly mediated by personality. Future research could focus on mechanisms leading to positive life events, as positive life events may buffer against development of mental health problems.

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“…This construct is highlighted in several of the articles. For example, Hankin, Badanes, Smolen, and Young (2015) find temporal sta bility of limbic-hypothalamic-pituitary-adrenal (LHPA) axis reac tivity to stress in children even before the development of psycho pathology. This stability is correlated with genetic polymorphisms in key serotonergic and glucocorticoid genes that regulate the stress response.…”

mentioning

confidence: 99%

“…Several of the articles highlight the dy namic relation of stress to psychopathology through the use of longitudinal designs spanning many months or years (Hankin et al, 2015;Laurent et al, 2015) or through designs that zoom in to examine moment-to-moment stability and change in reactivity (Hemaus et al, 2015;Ruscio et al, 2015). Others examine specific moderators of the impact of stress sensitivity.…”

mentioning

confidence: 99%

Stress sensitivity and stress sensitization in psychopathology: An introduction to the special section.

Harkness¹,

Hayden

Lopez-Duran

2015

Journal of Abnormal Psychology

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The goal of this special section is to examine the mechanisms of enhanced sensitivity and sensitization to stress as they influence the etiology and pathophysiology of psychopathology. The 12 articles in the section focus on some of the most crucial and unanswered questions regarding the underlying mechanisms and functional consequences of stress sensitivity and stress sensitization in psychopathology. They address the constructs of stress sensitivity and stress sensitization using state-of-the-art, and often novel, methodologies. The special section also focuses on an important terminological distinction between two related but distinct stress mechanisms that are often conflated. Individuals who are sensitive to stress possess this characteristic as a putative trait that develops through genetically mediated transactional relations between temperamental characteristics and the early contextual environment. In contrast, individuals who are sensitized to stress become so over time through repeated exposure to external, as well as endogenous, stressors. Enhanced stress sensitivity and sensitization have been included in conceptual models of psychopathology. Yet, the specific mechanisms by which these stress processes impact the onset and course of psychiatric disorders are not fully understood. These articles focus on several mechanistic accounts of stress sensitivity and sensitization.

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Cortisol reactivity to stress among youth: Stability over time and genetic variants for stress sensitivity.

Cited by 47 publications

References 108 publications

Depression from childhood through adolescence: risk mechanisms across multiple systems and levels of analysis

Depression from childhood through adolescence: risk mechanisms across multiple systems and levels of analysis

The effect of childhood trauma and Five-Factor Model personality traits on exposure to adult life events in patients with psychotic disorders

Stress sensitivity and stress sensitization in psychopathology: An introduction to the special section.

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