Cortisol Metabolism as a Regulator of the Tissue-Specific Glucocorticoid Action

Sbardella, Emilia; Tomlinson, Jeremy

doi:10.1007/978-3-319-45950-9_14

Cited by 2 publications

(5 citation statements)

References 196 publications

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“…As in the case of the other investigated genes, its mRNA levels were significantly decreased in the visceral adipose tissue of the patients with obesity, which is consistent with the findings of Veilleux et al [23]. The hexose-6-phosphate glucose 1-dehydrogenase causes the conversion of NADP to NADPH, which can be used by 11β-HSD1 in the reaction of converting cortisone to active cortisol [10]. Previous studies have shown that the expression of these two genes and the activity of the enzymes they encode are positively correlated [28].…”

Section: Discussionsupporting

confidence: 90%

“…Since genes encoding enzymes critical for cortisol synthesis and action are expressed in adipocytes (Figure 1) one can assume that obesity-related adipose tissue dysfunction may affect the local and systemic pool of this glucocorticoid [8]. The simplified pathway of glucocorticoid receptor signaling and the action of enzyme involved in glucocorticoid metabolism in adipocytes, based on [9][10][11]. In the absence o glucocorticoid, the glucocorticoid receptor (GR) is located in the cytoplasm and forms a complex with chaperones (hsp90, p23, hsp70) as well as immunophillins (FKBP51, FKBP52).…”

Section: Introductionmentioning

confidence: 99%

“…In contrast 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) catalyzes the opposite reaction, i.e., oxidize active cortisol into its inactive form [9]. If hexose-6-phosphate dehydrogenase (H6PDH) is present [9][10][11]. In the absence of glucocorticoid, the glucocorticoid receptor (GR) is located in the cytoplasm and forms a complex with chaperones (hsp90, p23, hsp70) as well as immunophillins (FKBP51, FKBP52).…”

Section: Introductionmentioning

confidence: 99%

“…Figure 1. The simplified pathway of glucocorticoid receptor signaling and the action of enzymes involved in glucocorticoid metabolism in adipocytes, based on[9][10][11]. In the absence of glucocorticoid, the glucocorticoid receptor (GR) is located in the cytoplasm and forms a complex with chaperones (hsp90, p23, hsp70) as well as immunophillins (FKBP51, FKBP52).…”

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confidence: 99%

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The Role of microRNA in the Regulation of Cortisol Metabolism in the Adipose Tissue in the Course of Obesity

Podraza,

Gutowska,

Lenartowicz

et al. 2024

IJMS

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The similarity of the clinical picture of metabolic syndrome and hypercortisolemia supports the hypothesis that obesity may be associated with impaired expression of genes related to cortisol action and metabolism in adipose tissue. The expression of genes encoding the glucocorticoid receptor alpha (GR), cortisol metabolizing enzymes (HSD11B1, HSD11B2, H6PDH), and adipokines, as well as selected microRNAs, was measured by real-time PCR in adipose tissue from 75 patients with obesity, 19 patients following metabolic surgery, and 25 normal-weight subjects. Cortisol levels were analyzed by LC-MS/MS in 30 pairs of tissues. The mRNA levels of all genes studied were significantly (p < 0.05) decreased in the visceral adipose tissue (VAT) of patients with obesity and normalized by weight loss. In the subcutaneous adipose tissue (SAT), GR and HSD11B2 were affected by this phenomenon. Negative correlations were observed between the mRNA levels of the investigated genes and selected miRNAs (hsa-miR-142-3p, hsa-miR-561, and hsa-miR-579). However, the observed changes did not translate into differences in tissue cortisol concentrations, although levels of this hormone in the SAT of patients with obesity correlated negatively with mRNA levels for adiponectin. In conclusion, although the expression of genes related to cortisol action and metabolism in adipose tissue is altered in obesity and miRNAs may be involved in this process, these changes do not affect tissue cortisol concentrations.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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The Role of microRNA in the Regulation of Cortisol Metabolism in the Adipose Tissue in the Course of Obesity

Podraza,

Gutowska,

Lenartowicz

et al. 2024

IJMS

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“…MG(18:1(9Z)/0:0/0:0) had positive correlations with prothrombin time (PT) and the level of Ca and negative correlations with red cell distribution width (RDW) and white blood cell (WBC), suggesting that a high level of MG(18:1(9Z)/0:0/0:0) may disrupt blood cell homeostasis and cause an adverse effect on COVID-19. Tetrahydrodeoxycortisol (THS) is derived from cortisol metabolism as a regulator of glucocorticoid action in liver and kidney [37] , [38] . For this reason, a negative relationship between THS and alanine aminotransferase (ALT) indicates that glucocorticoid might be an effective drug for improving the liver and kidney functions in COVID-19 patients.…”

Section: Resultsmentioning

confidence: 99%