Cortisol limits selected actions of synthetic glucocorticoids in the airway epithelium

Prodanovic, Danica; Keenan, Christine R.; Langenbach, Shenna; Li, Meina; Chen, Qianyu; Lew, Michael J.; Stewart, Alastair G.

doi:10.1096/fj.201700730r

Cited by 11 publications

(12 citation statements)

References 72 publications

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“…BEAS-2B cells were passaged (dilution, 1:3) every 3 or 4 days. In addition, air-liquid interface culture of BEAS-2B cells was performed as the reference [27].…”

Section: Cell Culturementioning

confidence: 99%

Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis

et al. 2020

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Background: Ferroptosis is a newly recognized type of cell death, which is different from traditional necrosis, apoptosis or autophagic cell death. However, the position of ferroptosis in lipopolysaccharide (LPS)-induced acute lung injury (ALI) has not been explored intensively so far. In this study, we mainly analyzed the relationship between ferroptosis and LPS-induced ALI. Methods: In this study, a human bronchial epithelial cell line, BEAS-2B, was treated with LPS and ferrostatin-1 (Fer-1, ferroptosis inhibitor). The cell viability was measured using CCK-8. Additionally, the levels of malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), and iron, as well as the protein level of SLC7A11 and GPX4, were measured in different groups. To further confirm the in vitro results, an ALI model was induced by LPS in mice, and the therapeutic action of Fer-1 and ferroptosis level in lung tissues were evaluated. Results: The cell viability of BEAS-2B was down-regulated by LPS treatment, together with the ferroptosis markers SLC7A11 and GPX4, while the levels of MDA, 4-HNE and total iron were increased by LPS treatment in a dose-dependent manner, which could be rescued by Fer-1. The results of the in vivo experiment also indicated that Fer-1 exerted therapeutic action against LPS-induced ALI, and down-regulated the ferroptosis level in lung tissues. Conclusions: Our study indicated that ferroptosis has an important role in the progression of LPS-induced ALI, and ferroptosis may become a novel target in the treatment of ALI patients.

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“…BEAS-2B cells were passaged (dilution, 1:3) every 3 or 4 days. In addition, air-liquid interface culture of BEAS-2B cells was performed as the reference [27].…”

Section: Cell Culturementioning

confidence: 99%

Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis

et al. 2020

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“…CRS is generally treated by pharmacotherapy or by FESS. 9 In this study, we evaluated CRS patients who had an average follow-up time of 1 year after undergoing FESS. Effective interpretation of clinical characteristics in CRS is very important, as it plays a deciding role in predicting the possibility of postoperative uncontrolled disease in these patients.…”

Section: Discussionmentioning

confidence: 99%

A novel risk score for disease control prediction of Chronic rhinosinusitis

Jiang

Wang

Lin

et al. 2022

Preprint

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Objectives: To assess the impact of risk factors on the disease control among CRS patients, following 1 year of functional endoscopic sinus surgery (FESS), and combining the risk factors to formulate a convenient, visualized prediction model. Design: A retrospective and nonconcurrent cohort study Setting and Participants: A total of 325 patients with Chronic rhinosinusitis (CRS) from June 2018 to July 2020 at the First Affiliated Hospital, the Third Affiliated Hospital, and the Seventh Affiliated Hospital of Sun Yat-sen University. Main Outcomes Measures: Outcomes were time to event measures: the disease control of CRS after surgery 1 year. The presence of nasal polyps, smoking habits, allergic rhinitis (AR), the ratio of tissue eosinophil (TER), and peripheral blood eosinophil count (PBEC)and asthma was assessed. The logistic regression models were used to conduct multivariate and univariate analyses. Asthma, TER, AR, PBEC were also included in the nomogram. The calibration curve and AUC (Area Under Curve) were used to evaluate the forecast performance of the model. Results: In univariate analyses, most of the covariates had significant associations with the endpoints, except for age, gender, and smoking. The nomogram showed the highest accuracy with an AUC of 0.760 (95% CI, 0.688-0.830) in the training cohort. Conclusions: In this cohort study that included the asthma, AR, TER, PBEC had significantly affected the disease control of CRS after surgery. The model provided relatively accurate prediction in the disease control of CRS after FESS and served as a visualized reference for daily diagnosis and treatment.

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“…Beyond the inhibition of hypocretin production, sleep fragmentation results in hypercortisolemia [25,26]. The state of raised cortisol can prevent the inhibition of granulocyte macrophage colony-stimulating factor (GCSF) that otherwise limits neutrophil levels [27], and may therefore further increase neutrophil production [28,29].…”

Section: Discussionmentioning

confidence: 99%

Broken sleep predicts hardened blood vessels

et al. 2020

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Why does poor-quality sleep lead to atherosclerosis? In a diverse sample of over 1,600 individuals, we describe a pathway wherein sleep fragmentation raises inflammatory-related white blood cell counts (neutrophils and monocytes), thereby increasing atherosclerosis severity, even when other common risk factors have been accounted for. Improving sleep quality may thus represent one preventive strategy for lowering inflammatory status and thus atherosclerosis risk, reinforcing public health policies focused on sleep health.

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Cortisol limits selected actions of synthetic glucocorticoids in the airway epithelium

Cited by 11 publications

References 72 publications

Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis

Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis

A novel risk score for disease control prediction of Chronic rhinosinusitis

Broken sleep predicts hardened blood vessels

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