Cortisol, leptin and free leptin index (FLI) in newborns in the first days of life and their importance for body weight programming

Kulik-Rechberger, Beata; Bury, Anna; Rakuś-Kwiatosz, Anna; Beń‐Skowronek, Iwona

doi:10.1186/s13052-019-0743-6

Cited by 3 publications

(3 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, our current study did not show a statistically significant relationship between SPX and leptin in both the blood of the umbilical cord as well as in the peripheral blood of healthy and obese mothers. The reason for the lack of correlation as well as significant changes between the groups of non-obese and obese women may be the date of collection (samples were taken on the day of delivery), where the mother’s body is exposed to many other factors that may affect the concentration of this peptide, such as stress factors or physiological changes of this peptide during pregnancy, where, as research has shown, the highest level of this adiponectin in blood serum occurs in the perinatal period [ 36 , 37 , 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

Cord Blood Spexin Level in Mothers with Obesity—Forecast of Future Obesity?

Wojciechowska,

Kolodziejski,

Pruszynska-Oszmalek

et al. 2023

Children

View full text Add to dashboard Cite

Spexin (SPX) is a peptide that plays an important role in the regulation of food intake and body weight (BW) by the effect on carbohydrate-lipid metabolism. However, the role of SPX in fetal life, in children, and in adolescent metabolism is limited. Therefore, we decided to check whether obesity affects the concentration of SPX in the mother’s peripheral blood (MB) and umbilical cord blood (UCB). Using MB and UCB sera on the day of delivery obtained from 48 women (24 non-obese and 24 obese) and commercially available Elisa kits and colorimetric assays, we determined changes in SPX and the relationship between SPX concentration and other metabolic and anthropometric markers (body weight and BMI) on the day of delivery and in children at the age of 36 months. We found lower concentrations of SPX in MB (p < 0.05) and UCB (p < 0.01) derived from obese women (BMI > 30) and a moderate linear correlation (r = 0.4429; p < 0.01) between SPX concentrations in MB and UCB. We also noted that the concentration of SPX is not correlated with the child’s body weight on the day of birth (r = −0.0128). However, there is a relationship between SPX at birth and body weight at 3 years of age (r = −0.3219; p < 0.05). Based on the obtained results, it can be assumed that spexin is one of the factors modulating the child’s metabolism already in the fetal period and can be considered a potential marker of future predisposition to obesity. However, confirmation of this thesis requires additional research.

show abstract

Section: Discussionmentioning

confidence: 99%

Cord Blood Spexin Level in Mothers with Obesity—Forecast of Future Obesity?

Wojciechowska,

Kolodziejski,

Pruszynska-Oszmalek

et al. 2023

Children

View full text Add to dashboard Cite

show abstract

“…There are reports on hormonal axes disturbances leading to metabolic syndrome [25]. Maternal obesity is implicated as another factor that may impair the development of the fetus [26]. However, epigenetic changes appear to be an essential element of fetal programming.…”

Section: Discussionmentioning

confidence: 99%

Comparison of application of Fenton, Intergrowth-21st and WHO growth charts in a population of Polish newborns

Jakubowski¹,

Salloum²,

Maciejewski³

et al. 2021

Clinical and Experimental Obstetrics & Gynecology

View full text Add to dashboard Cite

Background: Growth charts are the primary tools for evaluating neonatal birth weight and length. They help and qualify the neonates as Appropriate for Gestational Age (AGA), Small for Gestational Age (SGA), or Large for Gestational Age (LGA). The most commonly used neonatal charts include Intergrowth-21st, WHO, and Fenton. The aim of the study was to compare the tools used for assessing neonatal birth weight and the incidence of SGA and LGA using the different charts. Methods: Data on 8608 births in the Clinical Department of Obstetrics and Gynecology were compared. We divided the patient population into five gestational age groups. The 10th and 90th percentiles were calculated. The percentage of cases meeting the SGA and LGA criteria was determined. Results: Statistically significant differences between growth charts were identified for each of the groups. The 10th percentile for the study population corresponded to 2970 g for females and 3060 g for males born in the 40th week of gestation. The 90th percentile values were 4030 g and 4120 g. Our analysis showed a statistically significant difference in detection of LGA or SGA between three growth charts and our data both in male (χ 2 (3) = 157.192, p < 0.001, Kramer's V = 0.444) and female newborns (χ 2 (3) = 162.660, p < 0.001, Kramer's V = 0.464). Discussion: Our results confirm that differences exist between growth charts. There is a need for harmonizing growth assessment standards. It is recommended that a growth chart should be developed for the Polish population, which would improve the diagnosis of SGA and LGA.

show abstract

“…After birth, leptin levels in newborns (approximately 2.8 ng/mL; [ 58 ]) are crucial for postnatal developmental progress. In humans, the serum concentration of leptin begins to decrease during the first week of life (as low as 0.2 ng/mL; [ 59 ]) in parallel with a reduction in body weight [ 59 , 60 ]. This leptin–body weight reduction is linked with the growth of infants during their first year of life [ 59 ].…”

Section: Early Leptin For Future Cardiometabolic Outputmentioning

confidence: 99%

Temporal Leptin to Determine Cardiovascular and Metabolic Fate throughout the Life

2020

View full text Add to dashboard Cite

Leptin links peripheral adiposity and the central nervous system (CNS) to regulate cardiometabolic physiology. Within the CNS, leptin receptor-expressing cells are a counterpart to circulating leptin, and leptin receptor-mediated neural networks modulate the output of neuroendocrine and sympathetic nervous activity to balance cardiometabolic homeostasis. Therefore, disrupted CNS leptin signaling is directly implicated in the development of metabolic diseases, such as hypertension, obesity, and type 2 diabetes. Independently, maternal leptin also plays a central role in the development and growth of the infant during gestation. Accumulating evidence points to the dynamic maternal leptin environment as a predictor of cardiometabolic fate in their offspring as it is directly associated with infant metabolic parameters at birth. In postnatal life, the degree of serum leptin is representative of the level of body adiposity/weight, a driving factor for cardiometabolic alterations, and therefore, the levels of blood leptin through the CNS mechanism, in a large part, are a strong determinant for future cardiometabolic fate. The current review focuses on highlighting and discussing recent updates for temporal dissection of leptin-associated programing of future cardiometabolic fate throughout the entire life.

show abstract

Cortisol, leptin and free leptin index (FLI) in newborns in the first days of life and their importance for body weight programming

Cited by 3 publications

References 32 publications

Cord Blood Spexin Level in Mothers with Obesity—Forecast of Future Obesity?

Cord Blood Spexin Level in Mothers with Obesity—Forecast of Future Obesity?

Comparison of application of Fenton, Intergrowth-21st and WHO growth charts in a population of Polish newborns

Temporal Leptin to Determine Cardiovascular and Metabolic Fate throughout the Life

Contact Info

Product

Resources

About