Cortisol/DHEA ratio in morbidly obese patients before and after bariatric surgery: Relation to metabolic parameters and cardiovascular performance

El‐Zawawy, Hanaa Tarek; El-Aghoury, Aliaa Aly; Katri, Khaled; Elsharkawy, Eman; Gad, Samar Mohamed Samy

doi:10.1038/s41366-021-00997-x

Cited by 6 publications

(4 citation statements)

References 46 publications

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“…An increase in myristoleic acid, a class of long-chain fatty acids, has potential anti-obesity effects that involve activating brown adipose tissue and promoting the production of beige fat. In a previous study, the serum hydrocortisone concentration reportedly was decreased after SG ( 55 ), which is inconsistent with our findings. This discrepancy is probably related to regional differences in dietary structure, which may influence bacterial metabolites ( 56 ).…”

Section: Discussioncontrasting

confidence: 99%

New mechanistic insights of anti-obesity by sleeve gastrectomy-altered gut microbiota and lipid metabolism

Liu,

Xu,

Dong

et al. 2024

Front. Endocrinol.

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BackgroundThe obesity epidemic has been on the rise due to changes in living standards and lifestyles. To combat this issue, sleeve gastrectomy (SG) has emerged as a prominent bariatric surgery technique, offering substantial weight reduction. Nevertheless, the mechanisms that underlie SG-related bodyweight loss are not fully understood.MethodsIn this study, we conducted a collection of preoperative and 3-month postoperative serum and fecal samples from patients who underwent laparoscopic SG at the First Affiliated Hospital of Shandong First Medical University (Jinan, China). Here, we took an unbiased approach of multi-omics to investigate the role of SG-altered gut microbiota in anti-obesity of these patients. Non-target metabolome sequencing was performed using the fecal and serum samples.ResultsOur data show that SG markedly increased microbiota diversity and Rikenellaceae, Alistipes, Parabacteroides, Bactreoidales, and Enterobacteraies robustly increased. These compositional changes were positively correlated with lipid metabolites, including sphingolipids, glycerophospholipids, and unsaturated fatty acids. Increases of Rikenellaceae, Alistipes, and Parabacteroide were reversely correlated with body mass index (BMI).ConclusionIn conclusion, our findings provide evidence that SG induces significant alterations in the abundances of Rikenellaceae, Alistipes, Parabacteroides, and Bacteroidales, as well as changes in lipid metabolism-related metabolites. Importantly, these changes were found to be closely linked to the alleviation of obesity. On the basis of these findings, we have identified a number of microbiotas that could be potential targets for treatment of obesity.

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Section: Discussioncontrasting

confidence: 99%

New mechanistic insights of anti-obesity by sleeve gastrectomy-altered gut microbiota and lipid metabolism

Liu,

Xu,

Dong

et al. 2024

Front. Endocrinol.

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“…Cortisol and DHEA are steroid hormones with opposing effects. In obese patients, there is an increased concentration of cortisol, which in turn can cause a decrease in DHEA concentrations ( 25 ). We evaluated the cortisol/DHEA ratio at multiple time points of saliva sampling.…”

Section: Discussionmentioning

confidence: 99%

“…DHEA has anti-obesity ( 22 ), anti-diabetic ( 23 ), and anti-atherosclerotic properties ( 24 ). The ratio of cortisol to DHEA seems to be of particular importance, including indicators of metabolic and cardiovascular outcomes in obese patients after bariatric surgery ( 25 ). DHEA and dehydroepiandrosterone sulfate (DHEA-S) are defined as large reservoirs that easily converting into more potent androgens in peripheral tissues.…”

Section: Introductionmentioning

confidence: 99%

Effect of the one-day fasting on cortisol and DHEA daily rhythm regarding sex, chronotype, and age among obese adults

et al. 2023

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IntroductionPhysiological and biochemical processes in the human body occur in a specific order and show rhythmic variability. Time dependence characterizes the secretion of cortisol and dehydroepiandrosterone (DHEA). One-day fasting implies alternating fasting days and eating days. The study aimed to determine how 24-h fasting affects the daily rhythm of cortisol and DHEA levels in obese people while taking into account gender and chronotype.MethodsForty-nine obese patients (BMI 32.2–67.1 kg/m2; 25 women and 24 men) underwent a 3-week hospital-controlled calorie restriction diet to reduce body weight. During hospitalization, patients fasted for 1 day, during which only water could be consumed. Samples of whole mixed unstimulated saliva were collected at 2–3-h intervals over a 64-h period and analyzed for cortisol and DHEA by immunoassays. The individual chronotypes were assessed by the morning and evening questionnaire, according to Horne and Östberg. Three components of daily rhythm were evaluated: amplitude, acrophase, and the so-called MESOR.ResultsCortisol rhythm showed differences in amplitude (p = 0.0127) and acrophase (p = 0.0005). The amplitude on the fasting day was 11% higher (p = 0.224) than the day after. The acrophase advanced on the day of fasting, 48 min earlier than the day before (p = 0.0064), and by 39 min to the day after fasting (p = 0.0005). In the rhythm of DHEA, differences were found in the MESOR (p = 0.0381). The MESOR on the fasting day increased.DiscussionOur results obtained during 64 consecutive hours of saliva sampling suggest that one-day fasting may affect three components of cortisol and DHEA daily rhythm. Additionally, no differences were found in the daily rhythm between the morning and evening chronotypes and between females and males. Although aging did not influence daily cortisol rhythm, DHEA amplitude, MESOR, and acrophase changed with age. To the best of our knowledge, this is the first presentation of changes in DHEA rhythm during one-day fasting.

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“…There are several ways in which obesity increases cardiovascular and diabetes risk, including high lowdensity lipoprotein (LDL), total cholesterol, and triglyceride, low high-density lipoprotein (HDL), excessive fasting, postprandial blood glucose and hemoglobin A1c (HbA1c) and unsteady insulin levels [38,39]. Several studies reported that there may be a relationship between obesity andhormone levels icluding free T3, and T4, thyroid-stimulating hormone (TSH), estradiol, follicle-stimulating hormone (FSH), luteinizing hormone (LH), C-peptide, cortisol, adrenocorticotropic hormone (ACTH) and sex hormonebinding globulin (SHBG) [40][41][42][43]. Therefore, this study also aimed to investigate the association of GSTS1, GSTZ1, and GSTT1 expressios and complete blood count, cardiovascular and diabetes and hormoneparameters.…”

mentioning

confidence: 99%

Immunohistochemical approach to obesity disease in terms of expression levels of glutathione s-transferase (sigma, zeta, theta) isozymes

DAVUDOV

Buluş

Dirican

et al. 2023

The European Research Journal

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Objectives: Obesity is a complex multifactorial disease with recently increasing prevalence and incidence. Several studies have been conducted to explain the ethiology, pathophysiology, epidemiology, molecular and genetic mechanisms, and effective treatments of obesity. Glutathione S-transferase (GST) S1, GSTZ1, and GSTT1 are essential enzymes for oxidative stress and metabolism-related disorders. For this purpose, we aimed to reveal the role of GSTS1, GSTZ1, and GSTT1 in obesity. Methods: The gastric tissue samples were taken from the patients diagnosed with obesity who underwent bariatric surgery in Ankara Keçiören Training and Research Hospital General Surgery Clinic between 2017 and 2019. Immunostaining was performed on paraffin-embedded tissues to evaluate GSTS1, GSTZ1, and GSTT1 expressions. Laboratory data of the patients were recorded. All the results were analyzed statistically. Results: Weak GSTS1 expression was observed in 38.1% of tissues and moderate in 6.3%. 37.3% of the tissues presented weak GSTZ1 expression, and 11 (8.7%) displayed moderate. There were weak GSTT1 expressions in 7.1% of the tissues and moderate 0.8% of them. A positive and statistically significant correlation was observed between GSTS1 and GSTT1 expression levels ((r)=0.028, p = 0.010; p < 0.05). There were no significant differences between expression levels and gender, age, comorbidities, and medication usage (p > 0.05). Conclusions: GSTs, in particular GSTS1, GSTT1, and GSTZ1, might contribute to molecular mechanisms and the progression of obesity. In our study, GSTS1, GSTT1, and GSTZ1 were found to be moderately expressed in gastric tissues taken from obese patients. However, new studies using more samples and advanced techniques are needed to elucidate the relationship.

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Cortisol/DHEA ratio in morbidly obese patients before and after bariatric surgery: Relation to metabolic parameters and cardiovascular performance

Cited by 6 publications

References 46 publications

New mechanistic insights of anti-obesity by sleeve gastrectomy-altered gut microbiota and lipid metabolism

New mechanistic insights of anti-obesity by sleeve gastrectomy-altered gut microbiota and lipid metabolism

Effect of the one-day fasting on cortisol and DHEA daily rhythm regarding sex, chronotype, and age among obese adults

Immunohistochemical approach to obesity disease in terms of expression levels of glutathione s-transferase (sigma, zeta, theta) isozymes

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