Cortisol AuPd plasmonic unclad POF biosensor

Leitão, Cátia; Leal‐Junior, Arnaldo; Almeida, Ana Rita; Pereira, S.; Costa, F.M.; Pinto, João; Marques, Carlos

doi:10.1016/j.btre.2021.e00587

Cited by 93 publications

(41 citation statements)

References 23 publications

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“…Therefore, one approach consists in, firstly, immersing the sensors in a cysteamine solution to bind the thiol (-SH) functional groups of the cysteamine molecule to the Au surface through a strong affinity interaction. Secondly, the antibodies are covalently immobilized through the carboxylic acid (-COOH) functional groups to the cysteamine -NH 2 functional groups in the fiber surface, using EDC/NHS bioconjugate reagents [13,31,84,92], as schematized in Figure 10.…”

Section: Metal-coated Fibersmentioning

confidence: 99%

“…Another method, due to the presence of background noise in the response or because the blank response (samples without the presence of analyte) provides an analytical signal, takes into account the blank (Equation (5)) or LOB (Equation (6)) for LOD determination [ 80 , 82 ]. The former uses the mean apparent concentration of the blank and the SD of blank sample ( σ blank ) and, in the second approach, first the LOB is calculated (Equation (7)) followed by LOD determination (Equation (8)) [ 80 , 84 ]:

…”

Section: Theoretical Background On Optical Fiber Biosensing Working Principlesmentioning

confidence: 99%

“…The efficiency of this reaction can be enhanced by using N -hydroxysuccinimide (NHS) [ 91 ]. Usually, in order to guarantee an adequate orientation of the antibody, the amine (-NH 2 ) groups presented in the fiber surface are bonded to the carboxylic (-COOH) group belonging to the antibody terminal in the Fc region [ 84 , 92 ], whereas using GA, aldehyde groups from GA react with amine groups either from the fiber surface or from antibodies to promote their covalent linkage through imine bonds [ 91 , 93 ].…”

Section: Biofunctionalization Strategies For Optical Fiber Immunosensorsmentioning

confidence: 99%

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Immunosensing Based on Optical Fiber Technology: Recent Advances

et al. 2021

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The evolution of optical fiber technology has revolutionized a variety of fields, from optical transmission to environmental monitoring and biomedicine, given their unique properties and versatility. For biosensing purposes, the light guided in the fiber core is exposed to the surrounding media where the analytes of interest are detected by different techniques, according to the optical fiber configuration and biofunctionalization strategy employed. These configurations differ in manufacturing complexity, cost and overall performance. The biofunctionalization strategies can be carried out directly on bare fibers or on coated fibers. The former relies on interactions between the evanescent wave (EW) of the fiber and the analyte of interest, whereas the latter can comprise plasmonic methods such as surface plasmon resonance (SPR) and localized SPR (LSPR), both originating from the interaction between light and metal surface electrons. This review presents the basics of optical fiber immunosensors for a broad audience as well as the more recent research trends on the topic. Several optical fiber configurations used for biosensing applications are highlighted, namely uncladded, U-shape, D-shape, tapered, end-face reflected, fiber gratings and special optical fibers, alongside practical application examples. Furthermore, EW, SPR, LSPR and biofunctionalization strategies, as well as the most recent advances and applications of immunosensors, are also covered. Finally, the main challenges and an outlook over the future direction of the field is presented.

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Section: Metal-coated Fibersmentioning

confidence: 99%

…”

Section: Theoretical Background On Optical Fiber Biosensing Working Principlesmentioning

confidence: 99%

Section: Biofunctionalization Strategies For Optical Fiber Immunosensorsmentioning

confidence: 99%

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Immunosensing Based on Optical Fiber Technology: Recent Advances

et al. 2021

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“…Optical fiber-based LSPR sensors have been developed to detect different chemical and biomolecules such as enzymes, cortisol, cancer markers, and bacterial cells [ 78 , 79 , 90 , 91 , 92 , 93 ]. For example, cholesterol was detected by attaching cholesterol oxidase (ChOx) to AuNP-coated fiber via an adhesive layer of (3-mercaptopropyl) trimethoxysilane.…”

Section: Current Lspr Biosensors For the Detection Of Chemical And Biomoleculesmentioning

confidence: 99%

Biosensing Applications Using Nanostructure-Based Localized Surface Plasmon Resonance Sensors

Kim

Park

Jung

et al. 2021

Sensors

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Localized surface plasmon resonance (LSPR)-based biosensors have recently garnered increasing attention due to their potential to allow label-free, portable, low-cost, and real-time monitoring of diverse analytes. Recent developments in this technology have focused on biochemical markers in clinical and environmental settings coupled with advances in nanostructure technology. Therefore, this review focuses on the recent advances in LSPR-based biosensor technology for the detection of diverse chemicals and biomolecules. Moreover, we also provide recent examples of sensing strategies based on diverse nanostructure platforms, in addition to their advantages and limitations. Finally, this review discusses potential strategies for the development of biosensors with enhanced sensing performance.

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“…A combination of two insertions can be used as well [16]. Chemical sensing with high performance has also been demonstrated in biosensors using structures based on coated fiber probes with the effect of surface plasmon resonance [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Control of Excitation of Cladding Modes by Tapering an Insertion of Special Fiber

Bakurov

Иванов

2021

Sensors

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A method for controlling the excitation of cladding modes by tapering special fiber insertions made of SM450 and coreless fibers is proposed. The coupling coefficients between the core mode and the cladding modes of the tapered fiber insertion are calculated. For the calculation, changes in the effective refractive indices and phases of the fiber core and in the cladding modes upon tapering are found. The field distribution of the core mode of the standard fiber transmitted through fiber insertion is obtained. The transmission characteristics of insertions of SM450 and coreless fibers during tapering are simulated and compared with the experiment. The possibility of controlling the transmission and excitation of various cladding modes is confirmed experimentally.

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Cortisol AuPd plasmonic unclad POF biosensor

Cited by 93 publications

References 23 publications

Immunosensing Based on Optical Fiber Technology: Recent Advances

Immunosensing Based on Optical Fiber Technology: Recent Advances

Biosensing Applications Using Nanostructure-Based Localized Surface Plasmon Resonance Sensors

Control of Excitation of Cladding Modes by Tapering an Insertion of Special Fiber

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