Cortisol and transcortin in human seminal plasma and amniotic fluid as estimated by modern specific assays

Brotherton, Janet

doi:10.1111/j.1439-0272.1990.tb01966.x

Cited by 14 publications

(5 citation statements)

References 36 publications

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“…The reported mean values in the normospermic men varied from 59 to 176 nmol/L [ 20 -22 ], thus reaching from 11% [ 20 , 22 ] to 60% [ 21 ] of the respective serum levels. It is of special interest in light of the [ 16 ] fact that the glucocorticoids influence the testosterone biosynthesis through their receptors in the Leydig cells [ 23 , 24 ].…”

Section: Steroids In Testes -Their Biosynthesis and Role In Male Reprmentioning

confidence: 98%

Steroids in semen, their role in spermatogenesis, and the possible impact of endocrine disruptors

Hampl

Kubátová

Sobotka

et al. 2013

Hormone Molecular Biology and Clinical Investigation

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The data on hormonal steroids in the human seminal plasma and their role in spermatogenesis are summarized. The seminal steroid levels need not correlate with the blood plasma levels. The recent reports showed that androgen, especially dihydrotestosterone, and the estrogen levels in the seminal fluid may be used as the markers of spermatogenesis impairment. The estradiol concentration in the seminal plasma was higher than in the blood plasma, and its levels were significantly increased in men with impaired spermatogenesis. A good indicator for predicting the normal spermatogenesis, therefore, seems to be the testosterone/estradiol ratio. The seminal plasma also contains significant amounts of cortisol, which influences the androgen biosynthesis through its receptors in the Leydig cells. The local balance between cortisol and inactive cortisone is regulated by 11β-hydroxysteroid dehydrogenase, the activity of which may be affected by the environmental chemicals acting as the endocrine disruptors (EDCs). These compounds are believed to participate in worsening the semen quality - the sperm count, motility, and morphology, as witnessed in the recent last decades. As to the steroids' role in the testis, the EDCs may act as antiandrogens by inhibiting the enzymes of testosterone biosynthesis, as the agonists or antagonists through their interaction with the steroid hormone receptors, or at the hypothalamic-pituitary-gonadal axis. Surprisingly, though the EDCs affect the steroid action in the testis, there is no report of a direct association between the concentrations of steroids and the EDCs in the seminal fluid. Therefore, measuring the steroids in the semen, along with the various EDCs, could help us better understand the role of the EDCs in the male reproduction.

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Section: Steroids In Testes -Their Biosynthesis and Role In Male Reprmentioning

confidence: 98%

Steroids in semen, their role in spermatogenesis, and the possible impact of endocrine disruptors

Hampl

Kubátová

Sobotka

et al. 2013

Hormone Molecular Biology and Clinical Investigation

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“…Cortisol : There are only a few reports concerning seminal cortisol (see Refs [ 4 , 103 ]), though this steroid is known to affect negatively testosterone production in Leydig cells. An important counter-regulatory mechanism in these cells consists of the oxidation of excessive cortisol by 11β-hydroxysteroid dehydrogenase (11β-HSD) type 2.…”

Section: Using Seminal Hormones As Diagnostic and Prognostic Tools Inmentioning

confidence: 99%

“…putrescine , spermine , spermidine and cadaverine ), serving as a buffer to neutralize vaginal acidic conditions. In addition, the vaginal environment is rich in immune cells, the effect of which may be compensated for by various immuno-active molecules from the seminal plasma such as prostanoids (prostaglandins, leukotriens) [ 1 ], cytokines [ 2 , 3 ] and last but not least glucocorticoids [ 4 ]. Since sperm cells carry genetic information, it is very important to protect their DNA from acidic denaturation.…”

Section: Introductionmentioning

confidence: 99%

Occurrence and reproductive roles of hormones in seminal plasma

Vítků

Kolátorová

Hampl

2017

Basic Clin. Androl.

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Only 2–5% of seminal fluid is composed of spermatozoa, while the rest is seminal plasma. The seminal plasma is a rich cocktail of organic and inorganic compounds including hormones, serving as a source of nutrients for sperm development and maturation, protecting them from infection and enabling them to overcome the immunological and chemical environment of the female reproductive tract. In this review, a survey of the hormones found in human seminal plasma, with particular emphasis on reproductive hormones is provided. Their participation in fertilization is discussed including their indispensable role in ovum fertilization. The origin of individual hormones found in seminal plasma is discussed, along with differences in the concentrations in seminal plasma and blood plasma. A part of review is devoted to methods of measurement, emphasising particular instances in which they differ from measurement in blood plasma. These methods include separation techniques, overcoming the matrix effect and current ways for end-point measurement, focusing on so called hyphenated techniques as a combination of chromatographic separation and mass spectrometry. Finally, the informative value of their determination as markers of male fertility disorders (impaired spermatogenesis, abnormal sperm parameters, varicocele) is discussed, along with instances where measuring their levels in seminal plasma is preferable to measurement of levels in blood plasma.

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“…Furthermore, it is known that there is a strong correlation between serum and salivary cortisol concentrations in horses (Peeters et al, 2011). Unfortunately, the literature provides less detailed information regarding the cortisol concentration in seminal plasma (Brotherton, 1990; El‐Brady et al, 2016). Our results indicate that there is no clear correlation between the cortisol concentrations in saliva and seminal plasma (see Figure 2).…”

Section: Discussionmentioning

confidence: 99%

Dual use of breeding stallions is possible without affecting the sperm quality

Hensel¹,

Jakop²,

Schmicke³

et al. 2023

Reprod Domestic Animals

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Artificial insemination (AI) is commonly used in the equine industry to enhance the genetic value in breeding programs and to effectively utilize ejaculates. Many stallions are used as breeding stallions as well as in high‐level sports competitions to improve their market value. The goal of the present study was to investigate whether this dual use of stallions influences the animals´ stress levels and/or the quality of their ejaculates. For this purpose, 18 stallions were grouped into two categories: breeding stallions with (BSC = breeding stallion competition), and breeding stallions without secondary use in competitions (BS = breeding stallion). Two ejaculates were collected at a one‐week interval and analysed with an extended spectrum of spermatological methods. Furthermore, saliva, as well as seminal plasma samples were taken, and the concentration of cortisol therein was determined. Additionally, dehydroepiandrosterone (DHEA) and the cortisol/DHEA ratio were analysed and calculated for seminal plasma. After statistical analysis of the correlations and interdependences between the two groups, the results showed that the BSC group had significantly higher saliva cortisol levels (p = .027) and tendentially higher DHEA concentrations in their seminal plasma (p = .056). No difference between BS and BSC could be found in regard to the sperm quality parameters and the cortisol concentration in seminal plasma samples. It can be concluded that while active participation in competitions represents a stress factor, the dual use of stallions in breeding programs and sports competitions is possible without negative effects on their sperm quality.

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Cortisol and transcortin in human seminal plasma and amniotic fluid as estimated by modern specific assays

Cited by 14 publications

References 36 publications

Steroids in semen, their role in spermatogenesis, and the possible impact of endocrine disruptors

Steroids in semen, their role in spermatogenesis, and the possible impact of endocrine disruptors

Occurrence and reproductive roles of hormones in seminal plasma

Dual use of breeding stallions is possible without affecting the sperm quality

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