Cortisol affects testicular development in male common carp, Cyprinus carpio L., but not via an effect on LH secretion

Consten, D.; Lambert, J.G.D.; Goos, H.J.Th.

doi:10.1016/s1096-4959(01)00368-2

Cited by 31 publications

(17 citation statements)

References 14 publications

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“…High circulating cortisol levels typically lead to inhibition of gonadal development (54). In salmonids, plasma androgen levels were also suppressed by acute stress in male (49) and female (55) rainbow trout.…”

Section: Discussionmentioning

confidence: 99%

11β-Hydroxysteroid Dehydrogenase Complementary Deoxyribonucleic Acid in Rainbow Trout: Cloning, Sites of Expression, and Seasonal Changes in Gonads

2003

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11beta-Hydroxysteroid dehydrogenases (11beta-HSDs) are important steroidogenic enzymes for catalyzing the interconversion of active glucocorticoid (cortisol and corticosterone) and inert 11-keto forms (cortisone and 11-dehydrocorticosterone) in mammals. In teleosts, 11beta-HSD also plays a role in the production of the predominant androgen, 11-ketotestosterone, in male fish. In this study we cloned cDNAs encoding rainbow trout 11beta-HSD (rt11beta-HSD) from testes and head kidney. The predicted amino acid sequence, hydrophobicity analysis, and transient transfection assays with rt11beta-HSD in HEK293 cells showed that rt11beta-HSD is a homolog of mammalian 11beta-HSD type 2. rt11beta-HSD transcripts are present in steroidogenic tissues and in a number of other tissues. Strong in situ hybridization signals for rt11beta-HSD transcripts were found in Leydig cells of testes, in thecal cells of the early vitellogenic ovarian follicles, and in thecal and granulosa cells of the midvitellogenic and postovulatory follicles. Weaker signals were also found in head kidney interrenal cells from juvenile rainbow trout. Seasonal changes in rt11beta-HSD transcripts in testes showed a pattern similar to that of stress-induced serum cortisol levels, but not to serum androgen levels. High levels of rt11beta-HSD transcripts were found in ovarian follicles from late vitellogenesis through ovulation. These results raise the possibility of a role for rt11beta-HSD in the protection of developing gonads from the inhibitory effects of stress-induced cortisol.

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Section: Discussionmentioning

confidence: 99%

11β-Hydroxysteroid Dehydrogenase Complementary Deoxyribonucleic Acid in Rainbow Trout: Cloning, Sites of Expression, and Seasonal Changes in Gonads

2003

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“…Consequently, when the level of glucocorticoids among dominants in unstable conditions is at its peak, testosterone levels also reach their maximum, which suggests that GCs stimulate testosterone synthesis in dominants. In contrast, glucocorticoids are known to play an important role in the inhibition of testosterone secretion (Sidibe et al 1992;Consten et al 2001;Gao et al 2002;Dong et al 2004;Hardy et al 2005). Previous studies have also confirmed that high levels of glucocorticoids are associated with low levels of testosterone (Castro and Matt 1997;Fenske 1997;Consten et al 2001).…”

Section: Dominants Versus Subordinates: Testosterone Dynamicsmentioning

confidence: 98%

“…In contrast, glucocorticoids are known to play an important role in the inhibition of testosterone secretion (Sidibe et al 1992;Consten et al 2001;Gao et al 2002;Dong et al 2004;Hardy et al 2005). Previous studies have also confirmed that high levels of glucocorticoids are associated with low levels of testosterone (Castro and Matt 1997;Fenske 1997;Consten et al 2001). This decrease in the level of testicular androgens in the blood during times of stress likely results from the reduced synthesis of androgens in the testicles, which is caused by GCs and adrenocorticotropic hormones.…”

Section: Dominants Versus Subordinates: Testosterone Dynamicsmentioning

confidence: 98%

Testosterone dynamics during encounter: role of emotional factors

et al. 2012

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This study attempts to develop a new theory to explain the varying dynamics of testosterone levels in dominant (winners) and subordinate (losers) males, both pre- and post-encounter. The crux of our new theory consists of the following four theses: (1) the strengthening of testosterone synthesis is a result of not only the existence of challenges, but also of a positive mood before an encounter that is associated with the anticipation of a victory; (2) in situations where the anticipation of victory is present but the positive mood is absent, no rise in testosterone levels will occur; (3) testosterone acts as a "pleasure" hormone and usually releases in situations where the individual achieves or anticipates possible satisfaction; (4) an increased release of testosterone to the blood not only decreases anxiety but also elevates the mood, which increases animal's/human's assertiveness and consequently aggressiveness.

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“…As for rapidity, our findings suggest that glucocorticoids, androgens, and estrogens regulate similar changes in communication behavior over a rapid time course (within 5 min). Although chronically elevated glucocorticoids tend to suppress androgen levels (Matsumoto et al, 1970;Sapolsky, 1985;Jain et al, 1996;Consten et al, 2001), these two hormone classes may function synergistically over the short term. Plasma glucocorticoids and androgens can be released simultaneously during acute stress (Barbaccia et al, 1996;Oberbeck et al, 1998;Zinder and Dar, 1999) and territorial interactions (Hannes and Franck, 1983;Woodley et al, 2000), including those that involve vocalizations (Burmeister and Wilczynski, 2000).…”

Section: Behavioral Significancementioning

confidence: 99%

Rapid, Hierarchical Modulation of Vocal Patterning by Steroid Hormones

Remage‐Healey¹,

Bass²

2004

J. Neurosci.

158

140

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Vocal control systems have been identified in all major groups of jawed vertebrates. Although steroid hormones are instrumental in the long-term development and maintenance of neural structures underlying vocalization, it is unknown whether steroids rapidly modulate the neural activity of vocal motor systems. The midshipman fish generates advertisement and agonistic calls that mainly differ in duration. A descending midbrain pathway activates a hindbrain-spinal vocal circuit that directly establishes the discharge frequency and duration of the rhythmic vocal motor volley. This vocal motor output, which can be monitored from occipital nerve roots, directly determines the rate and duration of contraction of a pair of sonic muscles and, in turn, the fundamental frequency and duration of vocalizations. Here, we demonstrate that the duration of the vocal motor volley, or fictive vocalization, is rapidly responsive to steroid hormones, including androgens, estrogens, and glucocorticoids. These responses are consistent, in part, with a nongenomic mechanism and are steroid specific at the receptor level, suggesting the possibility of multiple membrane-bound receptor populations. We also show, using intact and semi-intact preparations, that steroids hierarchically modulate fictive vocalizations; whereas the hindbrain-spinal region is both necessary and sufficient for rapid (within 5 min) effects on duration, descending midbrain input is necessary for maintenance (up to 120 min) of these effects. The conserved nature of vertebrate vocal motor systems suggests that the neuroendocrine principles outlined in this study may be a fundamental feature of all vocal vertebrates.

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Cortisol affects testicular development in male common carp, Cyprinus carpio L., but not via an effect on LH secretion

Cited by 31 publications

References 14 publications

11β-Hydroxysteroid Dehydrogenase Complementary Deoxyribonucleic Acid in Rainbow Trout: Cloning, Sites of Expression, and Seasonal Changes in Gonads

11β-Hydroxysteroid Dehydrogenase Complementary Deoxyribonucleic Acid in Rainbow Trout: Cloning, Sites of Expression, and Seasonal Changes in Gonads

Testosterone dynamics during encounter: role of emotional factors

Rapid, Hierarchical Modulation of Vocal Patterning by Steroid Hormones

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