Corticotropin-releasing hormone (CRH)-immunoreactive (IR) axon varicosities target a subset of growth hormone-releasing hormone (GHRH)-IR neurons in the human hypothalamus

Peroski, M.; Proudan, Nikoletta; Grignol, George; Merchenthaler, Istvån; Dudás, Bertalan

doi:10.1016/j.jchemneu.2016.09.005

Cited by 6 publications

(4 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mitogenic effects of NPY seem to be mediated by the p44/42 MAPK pathway in some malignancies 3 . It has been suggested that NPY may influence GH release (by modulating growth hormone-releasing hormone (GHRH) secretion) 33 , thus modulating IGF-1 release. There was no association between the NPY rs16131 SNP and the serum concentration of IGF-1 (data not shown).…”

Section: Discussionmentioning

confidence: 99%

Energy homeostasis genes modify the association between serum concentrations of IGF-1 and IGFBP-3 and breast cancer risk

Rodríguez-Valentín

Torres-Mejı́a

Martínez-Matsushita

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Breast cancer is a multifactorial disease in which the interplay among multiple risk factors remains unclear. Energy homeostasis genes play an important role in carcinogenesis and their interactions with the serum concentrations of IGF-1 and IGFBP-3 on the risk of breast cancer have not yet been investigated. The aim of this study was to assess the modifying effect of the genetic variation in some energy homeostasis genes on the association of serum concentrations of IGF-1 and IGFBP-3 with breast cancer risk. We analyzed 78 SNPs from 10 energy homeostasis genes in premenopausal women from the 4-Corner’s Breast Cancer Study (61 cases and 155 controls) and the Mexico Breast Cancer Study (204 cases and 282 controls). After data harmonization, 71 SNPs in HWE were included for interaction analysis. Two SNPs in two genes (MBOAT rs13272159 and NPY rs16131) showed an effect modification on the association between IGF-1 serum concentration and breast cancer risk (Pinteraction < 0.05, adjusted Pinteraction < 0.20). In addition, five SNPs in three genes (ADIPOQ rs182052, rs822391 and rs7649121, CARTPT rs3846659, and LEPR rs12059300) had an effect modification on the association between IGFBP-3 serum concentration and breast cancer risk (Pinteraction < 0.05, adjusted Pinteraction < 0.20). Our findings showed that variants of energy homeostasis genes modified the association between the IGF-1 or IGFBP-3 serum concentration and breast cancer risk in premenopausal women. These findings contribute to a better understanding of this multifactorial pathology.

show abstract

Section: Discussionmentioning

confidence: 99%

Energy homeostasis genes modify the association between serum concentrations of IGF-1 and IGFBP-3 and breast cancer risk

Rodríguez-Valentín

Torres-Mejı́a

Martínez-Matsushita

et al. 2022

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Although the majority of the CRH-IR neurons are fusiform-shaped, numerous multipolar cells can be observed in the periventricular region. A dense network of CRH-positive axonal varicosities can be observed around the capillaries in the PVN and in the periventricular region (Peroski et al, 2016). CRH immunoreactivity was present in neurons of the PVN and in their fibers running to the median eminence.…”

Section: Corticotropin Releasing Hormone (Crh)mentioning

confidence: 92%

Neuropeptides of the human magnocellular hypothalamus

Pałasz

Vecchia

Saganiak

et al. 2021

Journal of Chemical Neuroanatomy

View full text Add to dashboard Cite

“…Consistent with the sensitivity of EM to changes in the PMI, Sarnat 2010 claim that EM is more sensitive to PMI artifacts than their light microscopy method of visualizing synapses by immunostaining with synaptophysin (Sarnat et al, 2010). Other authors have also claimed that light microscopy is more robust than EM to changes in the PMI in the visualization of synapses (Peroski et al, 2016).…”

Section: Electron Microscopymentioning

confidence: 95%

Postmortem changes in brain cell structure: a review

Krassner¹,

Kauffman²,

Sowa³

et al. 2023

Preprint

View full text Add to dashboard Cite

Brain cell structure is a key determinant of neural function that is frequently altered in neurobiological disorders. Following the global loss of blood flow to the brain that initiates the postmortem interval (PMI), cells rapidly become depleted of energy and begin to decompose. To ensure that our methods for studying the brain using autopsy tissue are robust and reproducible, there is a critical need to delineate the expected changes in brain cell morphometry during the PMI. We searched multiple databases to identify studies measuring the effects of PMI on the morphometry (i.e. external dimensions) of brain cells. We screened 2119 abstracts, 361 full texts, and included 172 studies. Mechanistically, fluid shifts causing cell volume alterations and vacuolization is an early event in the PMI, while loss of cell membrane visualization altogether is a later event. Decomposition rates are highly heterogenous and depend on the methods for visualization, the structural feature of interest, and modifying variables such as the storage temperature or the species. Geometrically, deformations of cell membranes are common early events that initiate within minutes. On the other hand, topological relationships between cellular features appear to be intact for more extended periods. Taken together, there is an uncertain length of time, usually ranging from several hours to several days, over which cell membrane structure is progressively lost. This review may be helpful for investigators studying human postmortem brain tissue, wherein the PMI is an unavoidable aspect of the research.

show abstract

Corticotropin-releasing hormone (CRH)-immunoreactive (IR) axon varicosities target a subset of growth hormone-releasing hormone (GHRH)-IR neurons in the human hypothalamus

Cited by 6 publications

References 40 publications

Energy homeostasis genes modify the association between serum concentrations of IGF-1 and IGFBP-3 and breast cancer risk

Energy homeostasis genes modify the association between serum concentrations of IGF-1 and IGFBP-3 and breast cancer risk

Neuropeptides of the human magnocellular hypothalamus

Postmortem changes in brain cell structure: a review

Contact Info

Product

Resources

About