Corticotropin-releasing factor type 1 receptors mediate the visceral hyperalgesia induced by repeated psychological stress in rats

Larauche, Muriel; Bradesi, Sylvie; Million, Mulugeta; McLean, Peter G.; Taché, Yvette; Mayer, Emeran A.; McRoberts, James A.

doi:10.1152/ajpgi.00507.2007

Cited by 76 publications

(74 citation statements)

References 65 publications

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“…SSR149415 and DMP-696 were equally effective at blocking chronic psychological stress-induced visceral hyperalgesia. This finding, together with earlier observations with different CRF1 antagonists (24,28,46), suggests that, in the chronic WAS model, CRF-and AVP-dependent pathways are activated sequentially and that, in contrast to acute stressors, chronic stress-dependent modulation of emotional and pain responses might depend on the sequential action of CRF-and AVP-signaling pathways. This double control might be similar to that regulating pituitary ACTH secretion and HPA axis activation during acute and chronic stress, which also depends on the interaction between CRF-and AVP-dependent mechanisms (11).…”

Section: Effect Of Repeated Dosing With Ssr149415 On the Development supporting

confidence: 70%

Involvement of vasopressin 3 receptors in chronic psychological stress-induced visceral hyperalgesia in rats

Bradesi¹,

Martínez²,

Lao³

et al. 2009

American Journal of Physiology-Gastrointestinal and Liver Physi

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Bradesi S, Martinez V, Lao L, Larsson H, Mayer EA. Involvement of vasopressin 3 receptors in chronic psychological stressinduced visceral hyperalgesia in rats. Am J Physiol Gastrointest Liver Physiol 296: G302-G309, 2009. First published November 25, 2008 doi:10.1152/ajpgi.90557.2008.-Visceral hypersensitivity and stress have been implicated in the pathophysiology of functional gastrointestinal disorders. We used a selective vasopressin 3 (V 3) receptor antagonist SSR149415 to investigate the involvement of the vasopressin (AVP)/V 3 signaling system in the development of stress-induced visceral hyperalgesia in rats. Rats were exposed to a daily 1-h session of water avoidance stress (WAS) or sham WAS for 10 consecutive days. The visceromotor response to phasic colorectal distension (CRD, 10 -60 mmHg) was assessed before and after stress. Animals were treated daily with SSR149415 (0.3, 1, or 3 mg/kg ip 30 min before each WAS or sham WAS session), with a single dose of SSR149415 (1 mg/kg ip), or the selective corticotropin-releasing factor 1 (CRF 1) antagonist DMP-696 (30 mg/kg po) before CRD at day 11. Effects of a single dose of SSR149415 (10 mg/kg iv) on acute mechanical sensitization during repetitive CRD (12 distensions at 80 mmHg) were also assessed. In vehicle-treated rats, repeated WAS increased the response to CRD, indicating visceral hypersensitivity. Repeated administration of SSR149415 at 1 or 3 mg/kg completely prevented stress-induced visceral hyperalgesia. Similarly, a single dose of DMP-696 or SSR149415 completely blocked hyperalgesic responses during CRD. In contrast, a single dose of SSR149415 did not affect the acute hyperalgesic responses induced by repeated, noxious distension. These data support a major role for V 3 receptors in repeated psychological stress-induced visceral hyperalgesia and suggest that pharmacological manipulation of the AVP/V 3 pathway might represent an attractive alternative to the CRF/CRF 1 pathway for the treatment of chronic stress-related gastrointestinal disorders. corticotropin-releasing factor; DMP-696; functional gastrointestinal disorders; irritable bowel syndrome; SSR149415RECURRENT ABDOMINAL PAIN ASSOCIATED with altered bowel habits and increased perception of physiological and experimental colonic stimuli (visceral hypersensitivity) are characteristic findings in patients with irritable bowel syndrome (IBS) (4). Although the pathophysiological basis of IBS is incompletely understood, epidemiological and experimental data indicate an important role of altered brain-gut interactions in this disorder. For example, many studies have highlighted the importance of certain types of psychological stress in the onset, maintenance, and exacerbation of IBS symptoms (5, 6, 32, 33). Furthermore, higher levels of anxiety, symptom-related anxiety, and comorbidity with anxiety disorders or depression are common in patients with IBS (32,33,49). Recent brain imaging studies have shown greater activation of limbic and paralimbic brain regions (including the amygdala) in patient...

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Section: Effect Of Repeated Dosing With Ssr149415 On the Development supporting

confidence: 70%

Involvement of vasopressin 3 receptors in chronic psychological stress-induced visceral hyperalgesia in rats

Bradesi¹,

Martínez²,

Lao³

et al. 2009

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…Visceral hyperalgesia (Bradesi et al, 2009(Bradesi et al, , 2007(Bradesi et al, , 2006He et al, 2013;Larauche et al, 2008 (Chen et al, 2011;Green et al, 2011b) Chapter 1…”

Section: Colorectal Distensionmentioning

confidence: 99%

Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey

Madasu

Okine

Olango

et al. 2016

Pharmacological Research

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“…This model elicits a greater deal of psychological stress than physical stress, and the consequent effects on gastrointestinal (GI) motility and visceral hyperalgesia have been examined (4,6,22,23). In the WA model, animals are placed on a floating board, which is an environment that induces psychological stress (29).…”

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confidence: 99%

Alteration of antral and proximal colonic motility induced by chronic psychological stress involves central urocortin 3 and vasopressin in rats

Ataka

Nagaishi

Asakawa

et al. 2012

American Journal of Physiology-Gastrointestinal and Liver Physi

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Ataka K, Nagaishi K, Asakawa A, Inui A, Fujimiya M. Alteration of antral and proximal colonic motility induced by chronic psychological stress involves central urocortin 3 and vasopressin in rats. Am J Physiol Gastrointest Liver Physiol 303: G519 -G528, 2012. First published May 25, 2012; doi:10.1152/ajpgi.00390.2011.-Because of the difficulties in developing suitable animal models, the pathogenesis of stress-induced functional gastrointestinal disorders is not well known. Here we applied the communication box technique to induce psychological stress in rats and then examined their gastrointestinal motility. We measured upper and lower gastrointestinal motility induced by acute and chronic psychological stress and examined the mRNA expression of various neuropeptides in the hypothalamus. Chronic psychological stress disrupted the fasted motility in the antrum and accelerated motility in the proximal colon. mRNA expression of AVP, oxytocin, and urocortin 3 was increased by chronic psychological stress. Intracerebroventricular (ICV) injection of urocortin 3 disrupted the fasted motility in the antrum, while ICV injection of Ucn3 antiserum prevented alteration in antral motility induced by chronic psychological stress. ICV injection of AVP accelerated colonic motility, while ICV injection of SSR 149415, a selective AVP V1b receptor antagonist, prevented alteration in proximal colonic motility induced by chronic psychological stress. Oxytocin and its receptor antagonist L 371257 had no effect on colonic motility in either the normal or chronic psychological stress model. These results suggest that chronic psychological stress induced by the communication box technique might disrupt fasted motility in the antrum via urocortin 3 pathways and accelerates proximal colonic motility via the AVP V1b receptor in the brain.brain-gut axis; arginine vasopressin V1b receptor; communication box PSYCHOLOGICAL STRESS, EXPOSURE to repeated stress-inducing stimuli for a long period, has been reported to trigger anxiety, depression, functional gastrointestinal disorders including irritable bowel syndrome, functional dyspepsia, and eating disorder (30). To investigate the pathogenesis of these stress-related disorders, various kinds of animal models including those of restraint stress, cold restraint stress, electrical foot shock stress, or water immersion stress have been used (20). However, since these models induce more physical than psychological stress on the animals, they might not accurately reflect human stress.Recently, the water avoidance (WA) stress model has been developed. This model elicits a greater deal of psychological stress than physical stress, and the consequent effects on gastrointestinal (GI) motility and visceral hyperalgesia have been examined (4,6,22,23). In the WA model, animals are placed on a floating board, which is an environment that induces psychological stress (29).The communication box (CB) technique has also been developed to induce psychological stress in animals without the need for physical stimu...

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Corticotropin-releasing factor type 1 receptors mediate the visceral hyperalgesia induced by repeated psychological stress in rats

Cited by 76 publications

References 65 publications

Involvement of vasopressin 3 receptors in chronic psychological stress-induced visceral hyperalgesia in rats

Involvement of vasopressin 3 receptors in chronic psychological stress-induced visceral hyperalgesia in rats

Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey

Alteration of antral and proximal colonic motility induced by chronic psychological stress involves central urocortin 3 and vasopressin in rats

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