Corticotropin-releasing factor receptors: Physiology, pharmacology, biochemistry and role in central nervous system and immune disorders

Souza, Errol B. De

doi:10.1016/0306-4530(95)00011-9

Cited by 397 publications

(239 citation statements)

References 119 publications

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“…In this regard, it has been reported (Lishmanov et al, 1987;Maslova et al, 1994) that R. rosea can reduce the secretion of corticotrophin-releasing factor (CRF), the major physiological mediator of stress (De Souza and Grigoriadis, 1994;Koob and Heinrichs, 1999). CRF also exerts an anxiogenic activity (Dunn and Berridge, 1990).…”

Section: Locomotor and Anxiolytic-like Activitiesmentioning

confidence: 99%

Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice

Perfumi

Mattioli

2006

Phytotherapy Research

150

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Rhodiola rosea L., or 'golden root', is a popular plant in traditional medicine in Eastern Europe and Asia, with a reputation for improving depression, enhancing work performance, eliminating fatigue and treating symptoms of asthenia subsequent to intense physical and psychological stress. Due to these therapeutic properties, R. rosea is considered to be one of the most active adaptogenic drugs. To confirm and extend results obtained in the few preclinical and clinical studies available in English language journals, the purpose of the present study was to re-investigate the effects produced by a single oral administration of an R. rosea hydroalcohol extract (containing 3% rosavin and 1% salidroside) on the central nervous system in mice. The extract was tested on antidepressant, adaptogenic, anxiolytic, nociceptive and locomotor activities at doses of 10, 15 and 20 mg/kg, using predictive behavioural tests and animal models. The results show that this R. rosea extract significantly, but not dose-dependently, induced antidepressant-like, adaptogenic, anxiolytic-like and stimulating effects in mice. This study thus provides evidence of the efficacy of R. rosea extracts after a single administration, and confirms many preclinical and clinical studies indicating the adaptogenic and stimulating effects of such R. rosea extracts. Moreover, antidepressant-like and anxiolytic-like activities of R. rosea were shown in mice for the first time.

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Section: Locomotor and Anxiolytic-like Activitiesmentioning

confidence: 99%

Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice

Perfumi

Mattioli

2006

Phytotherapy Research

150

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“…Recently, CRH + innervation of NE neurons has been described (Zhang et al , 2017), including at the ultrastructural level (Van Bockstaele et al , 1996). However, a monosynaptic circuit operating through excitatory CRH [i.e., CRH acting at G s protein‐coupled Crhr1 and/or Crhr2 receptors (De Souza, 1995)] seems insufficient to functionally convert short‐lived surges of excitability into long‐lasting NE sensitization for cortical stress adaptation, particularly since neuropeptide release likely commences only upon intense burst firing (Overton & Clark, 1997). …”

Section: Introductionmentioning

confidence: 99%

Hypothalamic CNTF volume transmission shapes cortical noradrenergic excitability upon acute stress

et al. 2018

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Stress‐induced cortical alertness is maintained by a heightened excitability of noradrenergic neurons innervating, notably, the prefrontal cortex. However, neither the signaling axis linking hypothalamic activation to delayed and lasting noradrenergic excitability nor the molecular cascade gating noradrenaline synthesis is defined. Here, we show that hypothalamic corticotropin‐releasing hormone‐releasing neurons innervate ependymal cells of the 3rd ventricle to induce ciliary neurotrophic factor (CNTF) release for transport through the brain's aqueductal system. CNTF binding to its cognate receptors on norepinephrinergic neurons in the locus coeruleus then initiates sequential phosphorylation of extracellular signal‐regulated kinase 1 and tyrosine hydroxylase with the Ca2+‐sensor secretagogin ensuring activity dependence in both rodent and human brains. Both CNTF and secretagogin ablation occlude stress‐induced cortical norepinephrine synthesis, ensuing neuronal excitation and behavioral stereotypes. Cumulatively, we identify a multimodal pathway that is rate‐limited by CNTF volume transmission and poised to directly convert hypothalamic activation into long‐lasting cortical excitability following acute stress.

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“…The molecular mechanism underlying the neonatal isolation-induced elevation of NR2B gene transcription is unknown; however, two possible mechanisms can be proposed. Because the promoter region of NR2B gene contains a cAMP responsive element-binding protein (CREB) consensus sequence (Myers et al, 1999) and the activation of CRF-R1 is known to stimulate G s protein that activates adenylyl cyclase, leading to cAMP accumulation with subsequent protein kinase A (PKA) activation and CREB phosphorylation (De Souza, 1995), it is therefore likely that neonatal isolation may promote the developmental production of NR2B levels through the enhanced CRF production and release, and the consequent activation of CRF-R1 in the hippocampal CA1 neurons to increase PKA-dependent signaling. An alternative possibility is that neonatal isolation may slow the developmental decline of the NR2B mRNA levels (Naassila and Daoust, 2002).…”

Section: Discussionmentioning

confidence: 99%

Neonatal Isolation Delays the Developmental Decline of Long-Term Depression in the CA1 Region of Rat Hippocampus

Huang

Chao

et al. 2008

Neuropsychopharmacol

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Activity-dependent alterations of synaptic efficacy or connectivity are essential for the development, signal processing, and learning and memory functions of the nervous system. It was observed that, in particular in the CA1 region of the hippocampus, low-frequency stimulation (LFS) became progressively less effective at inducing long-term depression (LTD) with advancing developmental age. The physiological factors regulating this developmental plasticity change, however, have not yet been elucidated. Here we examined the hypothesis that neonatal isolation (once per day for 1 h from postnatal days 1-7) is able to alter processes underlying the developmental decline of LTD. We confirm that the magnitude of LTD induced by LFS (900 stimuli at 1 Hz) protocol correlates negatively with developmental age and illustrates that neonatal isolation delays this developmental decline via the activation of corticotrophin-releasing factor (CRF) system. Furthermore, this modulation appears to be mediated by an increased transcription of N-methyl-D-aspartate receptor NR2B subunits. We also demonstrate that intracerebroventricular injection of CRF postnatally mimicked the effect of neonatal isolation to increase the expression of NR2B subunits and delayed the developmental decline of LTD, which was specifically blocked by CRF receptor 1 antagonist NBI27914 pretreatment. These results suggest a novel role for CRF in regulating developmental events in the hippocampus and indicate that although maternal deprivation is stressful for neonate, appropriate neonatal isolation can serve to promote an endocrine state that may regulate the gradual developmental change in the induction rules for synaptic plasticity in the hippocampal CA1 region.

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Corticotropin-releasing factor receptors: Physiology, pharmacology, biochemistry and role in central nervous system and immune disorders

Cited by 397 publications

References 119 publications

Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice

Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice

Hypothalamic CNTF volume transmission shapes cortical noradrenergic excitability upon acute stress

Neonatal Isolation Delays the Developmental Decline of Long-Term Depression in the CA1 Region of Rat Hippocampus

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