Corticotropin-releasing factor overexpression decreases ethanol drinking and increases sensitivity to the sedative effects of ethanol

Palmer, Abraham A.; Sharpe, Amanda L.; Burkhart‐Kasch, Sue; McKinnon, Carrie S.; Coste, Sarah C.; Stenzel-Poore, Mary P.; Phillips, Tamara J.

doi:10.1007/s00213-004-1896-5

Cited by 38 publications

(37 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, although the relatively stress-insensitive C57BL/6J strain [3,36,56] did not respond to stress while 'stress-sensitive' BALB/cByJ did, DBA/2J mice also responded, even though this strain is typically similar to C57BL/6J on measures of anxiety-like behavior and stress-reactivity [3,36,56]. While we did not conduct a strain comparison of glucocorticoid response profiles to our stress paradigm, these data suggest that the relationship between strain differences in stress reactivity and twobottle EtOH self-administration is likely to be complex and modulated by multiple factors.Increased sensitivity to the sedative/hypnotic effects of EtOH is one factor associated with lesser EtOH drinking in mice [11,40,44,57]. Confirming our recent finding [5], chronic swim stress significantly potentiated sleep time responses to 4 g/kg EtOH measured twenty-four hours after the final stressor in C57BL/6J mice.…”

supporting

confidence: 84%

See 1 more Smart Citation

Effects of chronic swim stress on EtOH-related behaviors in C57BL/6J, DBA/2J and BALB/cByJ mice

Boyce-Rustay

Janos

Holmes

2008

Behavioural Brain Research

View full text Add to dashboard Cite

There is a strong clinical relationship between stress and stress-related disorders and the incidence of alcohol abuse and alcoholism, and this relationship appears to be partly genetic in origin. There are marked strain differences in ethanol (EtOH)-related behaviors and reactivity to stress, but little investigation of the interaction between the two. The present study assessed the effects of chronic exposure to swim stress on EtOH-related behavior in three common inbred strains of mice, C57BL/ 6J, DBA/2J and BALB/cByJ. After establishing baseline (10%) EtOH self-administration in a twobottle free choice test, mice were exposed to daily swim stress for 14 consecutive days and EtOH consumption measured as a percent of baseline both during stress and for 10 days afterwards. A separate experiment examined the effects of 14 days of swim stress on sensitivity to the sedative/ hypnotic effects of an acute injection of 4 g/kg EtOH. Results showed that stress produced a marked and prolonged decrease in EtOH consumption in DBA/2J and BALB/cByJ, but not C57BL/6J mice. By contrast, stress increased sensitivity to the sedative/hypnotic effects of EtOH across all 3 strains. These findings demonstrate that chronic swim stress produces reductions in EtOH self-administration in a strain-dependent manner, and that these effects may be restricted to low-consuming strains. Present data also indicate a dissociation between effects of this stressor on EtOH self-administration and sensitivity to EtOH's sedative/hypnotic effects. In conclusion, strain differences, that are likely in large part genetic in nature, modify the effects of this stressor on EtOH's effects in a behaviorspecific manner. Keywords mouse; strain; ethanol; sedation; gene; drinking; swim stress; preference; two-bottle choice There is a strong epidemiological link between stress-related psychiatric disorders and alcoholism. Individuals suffering from depression or anxiety disorders, conditions often associated with stress, are more likely to abuse alcohol and become alcoholic, and tend to respond less well to therapeutic interventions [8,9,29,54]. Moreover, a history of adverse life events positively correlates with increased rates of alcoholism; although, interestingly, a proportion of individuals become abstinent following stress [19,35,46,51]. These clinic data lend support to the influential hypothesis that stress represent a significant risk factor for alcoholism [12,28]. *Corresponding author: R4N5 AP9A-L018, Abbott Laboratories, 100 Abbott Park Rd, Abbott Park, IL 60064, Ph. +1-847-937-2559, Fax +1-847-938-0072, E-mail: janel.boyce-rustay@abbott.com. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered wh...

show abstract

supporting

confidence: 84%

“…Increased sensitivity to the sedative/hypnotic effects of EtOH is one factor associated with lesser EtOH drinking in mice [11,40,44,57]. Confirming our recent finding [5], chronic swim stress significantly potentiated sleep time responses to 4 g/kg EtOH measured twenty-four hours after the final stressor in C57BL/6J mice.…”

supporting

confidence: 84%

Effects of chronic swim stress on EtOH-related behaviors in C57BL/6J, DBA/2J and BALB/cByJ mice

Boyce-Rustay

Janos

Holmes

2008

Behavioural Brain Research

View full text Add to dashboard Cite

show abstract

“…Craving as an important dimension of addictive behavior has been linked with serum levels of leptin in different studies (Kiefer et al, 2001a,b;Hillemacher et al, 2007a,b). It has been hypothesized that circulating leptin influences the function of the hypothalamic-pituitary-adrenal axis (HPA-axis) by inhibiting hypothalamic release of corticotropin-releasing hormone (CRH), which has been linked to alcohol craving in different studies (Olive et al, 2003;Palmer et al, 2004;Zorrilla et al, 2014). In line with our results elevated LEP gene promoter methylation can be hypothesized to lead to a decrease of leptin serum levels and subsequently to a decrease of CRH-release inhibition.…”

Section: Discussionsupporting

confidence: 89%

DNA methylation of the LEP gene is associated with craving during alcohol withdrawal

Hillemacher

Weinland

Lenz

et al. 2015

Psychoneuroendocrinology

View full text Add to dashboard Cite

“…An inverse relationship between sensitivity to EtOH's sedative/hypnotic effects and voluntary EtOH consumption has been found in some, although certainly not all, genetically selected and mutant strains of mice (Church et al 1979;Crabbe et al 2006;Naassila et al 2002;Palmer et al 2004;Thiele et al 2000). Along similar lines, reduced sensitivity and more rapid development of acute functional tolerance to some of EtOH's acute intoxicating effects have been associated with increased risk for alcoholism in humans (Newlin and Thomson 1990;Schuckit 1985).…”

Section: Discussionmentioning

confidence: 88%

An investigation of the behavioral actions of ethanol across adolescence in mice

2007

View full text Add to dashboard Cite

show abstract

Corticotropin-releasing factor overexpression decreases ethanol drinking and increases sensitivity to the sedative effects of ethanol

Abstract: These data show that CRF overexpressing mice voluntarily consume less EtOH. This difference is associated with greater sensitivity to the sedative-hypnotic effects of EtOH, but not with increased sensitivity to the aversive effects of EtOH.

Cited by 38 publications

References 41 publications

Effects of chronic swim stress on EtOH-related behaviors in C57BL/6J, DBA/2J and BALB/cByJ mice

Effects of chronic swim stress on EtOH-related behaviors in C57BL/6J, DBA/2J and BALB/cByJ mice

DNA methylation of the LEP gene is associated with craving during alcohol withdrawal

An investigation of the behavioral actions of ethanol across adolescence in mice

Contact Info

Product

Resources

About