Corticotropin-releasing factor modulates maternal separation-induced ultrasonic vocalization in rat pups via activation of CRF1 receptor

Ise, Satoko; Nagano, Norihiro; Okuda, Suguru; Ohta, Hisashi

doi:10.1016/j.brainres.2008.07.079

Cited by 16 publications

(12 citation statements)

References 33 publications

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“…In mammals, acute maternal separation produces a stress response in the infant that includes activation of the HPA axis and autonomic changes; ultrasonic vocalizations are considered to be a behavioral component of this response (Brunelli, 2005; Hennessy et al, 1999). These USVs are modulated by stress hormones (Harvey et al, 1994; Hennessy et al, 1999; Ise et al, 2008) and depend on brain regions known in adults to mediate other distress responses (Wiedenmayer et al, 2000). Moreover, they are increased and decreased by neuroactive compounds known in adults to be anxiogenic and anxiolytic, respectively (Hofer, 1996; Ise et al, 2008; Podhorna and Brown, 2000; Trezza et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…These USVs are modulated by stress hormones (Harvey et al, 1994; Hennessy et al, 1999; Ise et al, 2008) and depend on brain regions known in adults to mediate other distress responses (Wiedenmayer et al, 2000). Moreover, they are increased and decreased by neuroactive compounds known in adults to be anxiogenic and anxiolytic, respectively (Hofer, 1996; Ise et al, 2008; Podhorna and Brown, 2000; Trezza et al, 2008). The phenotype may also be predictive of a persistent anxiety-like phenotype, as rats selectively bred for high distress vocalizations show a number of anxiety-related phenotypes as adults (Brunelli, 2005).…”

Section: Discussionmentioning

confidence: 99%

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Moderate recurrent hypoglycemia during early development leads to persistent changes in affective behavior in the rat

Moore

Craft

Grimaldi

et al. 2010

Brain, Behavior, and Immunity

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Recurrent hypoglycemia is a common problem among infants and children that is associated with several metabolic disorders and insulin-dependent diabetes mellitus. Although studies have reported a relationship between a history of juvenile hypoglycemia and psychological health problems, the direct effects of recurrent moderate hypoglycemia have not been fully determined. Thus, in this study, we used an animal model to examine the effects of recurrent hypoglycemia during the juvenile period on affective, social, and motor function (assessed under euglycemic conditions) across development. To model recurrent hypoglycemia, rats were administered 5 U/kg of insulin or saline twice per day from postnatal day (P)10 to P19. Body weight gain was retarded in insulin-treated rats during the treatment period, but recovered by the end of treatment. However, insulin-treated rats displayed increases in affective reactivity that emerged early during treatment and persisted after treatment into early adulthood. Specifically, insulin-treated pups showed increased maternal separation-induced vocalizations as infants, and an exaggerated acoustic startle reflex as juveniles and young adults. Moreover, young adult rats with a history of recurrent juvenile hypoglycemia exhibited increased fear-potentiated startle and increases in behavioral and hormonal responses to restraint stress. Some of these effects were sex-dependent. The changes in affective behavior in insulin-exposed pups were accompanied by decreases in adolescent social play behavior. These results provide evidence that recurrent, transient hypoglycemia during juvenile development can lead to increases in fear-related behavior and stress reactivity. Importantly, these phenotypes are not reversed with normalization of blood glucose and may persist into adulthood.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Moderate recurrent hypoglycemia during early development leads to persistent changes in affective behavior in the rat

Moore

Craft

Grimaldi

et al. 2010

Brain, Behavior, and Immunity

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“…Impaired communication of the pups with their mothers, a typical symptom of autism [1], was assessed by ultrasonic vocalization, validated for rat model of autism [9,34]. Rodent pups emit vocalizations (band frequency of 30-50 kHz) when isolated from their mothers, and these vocalizations are thought to solicit maternal interactions [35,36]. On PND 11, immediately after the pups were isolated from their nests and mothers, they were individually placed in a polypropylene cage (30 × 20 × 12 cm) and brought to a testing room at a controlled temperature of 22°C ± 2°C that was separate from the housing room.…”

Section: Ultrasonic Vocalizationmentioning

confidence: 99%

Prenatal zinc prevents communication impairments and BDNF disturbance in a rat model of autism induced by prenatal lipopolysaccharide exposure

Kirsten

Queiroz‐Hazarbassanov

Bernardi

et al. 2015

Life Sciences

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Aims: Previous investigations by our group have shown that prenatal exposure to lipopolysaccharide (LPS),which mimics infections by Gram-negative bacteria, induced autistic-like behavior. No effective treatment yet exists for autism. Therefore, we used our rat model to test a possible treatment for autism.We selected zinc as the prenatal treatment to prevent or ease the impairments induced by LPS because LPS induces hypozincaemia.Materials and methods:We evaluated the effects of LPS and zinc on female reproductive performance. Communication,which is impaired in autism,was tested in pups by ultrasonic vocalizations. Plasma levels of brain-derived neurotrophic factor (BDNF) were determined because it has been considered an autism important biomarker.Key findings: Prenatal LPS exposure reduced offspring number and treatment with zinc prevented this reduction.Moreover, pups that were prenatally exposed to LPS spent longer periods without calling their mothers, and posttreatment with zinc prevented this impairment induced by LPS to the same levels as controls. Prenatal LPS also increased BDNF levels in adult offspring, and posttreatment with zinc reduced the elevation of BDNF to the same levels as controls.Significance: BDNF hyperactivity was also found in several studies of autistic patients. Together with our previous studies, our model of prenatal LPS induced autistic-like behavioral, brain, and immune disturbances. This suggests that it is a valid rat model of autism. Prenatal zinc prevented reproductive, communication, and BDNF impairments.The present study revealed a potential beneficial effect of prenatal zinc administration for the prevention of autism with regard to the BDNF pathway.

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“…Corticotropin-releasing factor and oxytocin may represent two neuropeptides that antidepressants target to modulate separation distress and social attachment. Corticotropin-releasing factor, besides playing a general role in the stress response, can induce separation vocalizations in rodents via activation of the CRF1 receptor (Ise, Nagano, Okuda, & Ohta, 2008). Both fluoxetine and amitryptiline have been found to reduce corticotrophin-releasing factor concentrations in human cerebrospinal fluid (De Bellis, Gold, Geracioti, Listwak, & Kling, 1993;Heuser et al, 1998).…”

Section: Crying Infant Rats the Pain Of Separation And A Mother In mentioning

confidence: 95%

Antidepressant Psychopharmacology and the Social Brain

Novick

2011

Psychiatry: Interpersonal and Biological Processes

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Antidepressant drugs are a mainstay in psychiatric treatment and have the ability to influence neural substrates related to social bonding and interaction. This article explores the potential neurobiological overlap between social attachment and antidepressant mechanisms and reviews work related to the effects of antidepressants on separation distress, social affiliation, dominance hierarchies, romantic love, and socio-emotional processing. It is proposed that similarities between antidepressant pharmacology and the neurobiological effects of an effective care-giver may help create a sense of safety that in turn promotes changes in behavior and mood.

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Corticotropin-releasing factor modulates maternal separation-induced ultrasonic vocalization in rat pups via activation of CRF1 receptor

Cited by 16 publications

References 33 publications

Moderate recurrent hypoglycemia during early development leads to persistent changes in affective behavior in the rat

Moderate recurrent hypoglycemia during early development leads to persistent changes in affective behavior in the rat

Prenatal zinc prevents communication impairments and BDNF disturbance in a rat model of autism induced by prenatal lipopolysaccharide exposure

Antidepressant Psychopharmacology and the Social Brain

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