Corticotropin-Releasing Factor Inhibits Maternal Aggression in Mice.

Gammie, Stephen C.; Negrón, Arnaldo E.; Newman, Sarah M.; Rhodes, Justin S.

doi:10.1037/0735-7044.118.4.805

Cited by 117 publications

(184 citation statements)

References 47 publications

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“…Previous studies have found that isoflurane can depress c-Fos in the spinal cord (Jinks et al, 2002), but elevate it in the hypothalamus in aged rats (Jansson et al, 2004), so it is not clear how isoflurane may have acted in this study, if at all on c-Fos expression. As indicated above, the use of isoflurane in association with injection here was aimed to reduce stress effects of injection and its previous use in association with injection has not been found not to overtly impair aggression or other maternal behaviors (D'Anna et al, 2005;D'Anna and Gammie, 2006;Gammie et al, 2004). Exactly whether or how CDP and isoflurane may interact at the doses used in this study would need to be examined in subsequent experiments.…”

Section: Discussionmentioning

confidence: 97%

“…LS is a prime candidate for modulation of maternal defense by BDZs because it is associated with fear and anxiety (Numan and Insel, 2003;Pesold and Treit, 1996;Singewald et al, 2003) and previously has been hypothesized to be a critical site of negative regulation for maternal aggression (D'Anna et al, 2005;Gammie et al, 2004). For example, for three peptides that inhibit maternal aggression, CRF (Gammie et al, 2004), urocotin (Ucn) 1, and Ucn 3 (D' Anna et al, 2005), c-Fos activity in LS was elevated with treatment at the dose that impaired aggression.…”

Section: Discussionmentioning

confidence: 99%

“…For example, for three peptides that inhibit maternal aggression, CRF (Gammie et al, 2004), urocotin (Ucn) 1, and Ucn 3 (D' Anna et al, 2005), c-Fos activity in LS was elevated with treatment at the dose that impaired aggression. Also, in association with lactation, LS shows a blunted reactivity to stressors and centrally administered CRF ( da Costa et al, 1996;da Costa et al, 1997), suggesting altered LS activity supports maternal behaviors, including defense.…”

Section: Discussionmentioning

confidence: 99%

“…or i.p.) 30 min prior to testing does not impair production of maternal aggression or other maternal behaviors ( D'Anna et al, 2005;D'Anna and Gammie, 2006;Gammie et al, 2004). Immediately after injection, each mouse was placed back in the homeroom for 30 min prior to behavioral testing.…”

Section: Pharmacological Treatment and Injectionmentioning

confidence: 99%

“…The images of brain sections were projected from an Axioskop Zeiss light microscope (Zeiss, Gottingen, Germany) through an Axiocam Zeiss high-resolution digital camera attached to the microscope and interfaced with a computer. Counting was based on a previously used paradigm ( Gammie and Nelson, 2001;Gammie et al, 2004). Using boxes, cells in a specific region on a specific section were automatically counted.…”

Section: Analysis Of C-fos Immunoreactivitymentioning

confidence: 99%

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GABA enhancement of maternal defense in mice: Possible neural correlates

Lee

Gammie

2007

Pharmacology Biochemistry and Behavior

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Previous studies have shown that low doses of GABA A receptor agonists facilitate maternal defense of offspring (maternal aggression), without significantly affecting other maternal behaviors. In addition, it has been demonstrated that endogenous changes in GABAergic neurotransmission occur in association with lactation. This study investigated the effects of GABA A receptor agonist, chlordiazepoxide (CDP), a benzodiazepine (BDZ), on maternal behaviors including aggression, and identified brain regions with altered activity in association with treatment. Another aim of the study was to determine whether CDP injections could prevent decreases in maternal aggression that occur with pup separation. Intraperitoneal injections of 1mg/kg of CDP significantly increased maternal defense without affecting other maternal behaviors, although a trend towards elevated nursing was noted. CDP significantly reduced c-Fos in lateral septum (LS) and caudal periaqueductal gray (cPAG) in behaviorally-experienced mice relative to vehicle-injected controls. In behaviorally-naïve subjects, CDP also decreased c-Fos in LS, but in cPAG this decrease was just above significance (p = 0.051). CDP was not sufficient to "rescue" maternal aggression when pup stimulus was removed. Overall, these studies provide further insights into the role for GABA in maternal behaviors, including aggression, and how and where BDZs may act to modulate behavior.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Pharmacological Treatment and Injectionmentioning

confidence: 99%

Section: Analysis Of C-fos Immunoreactivitymentioning

confidence: 99%

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GABA enhancement of maternal defense in mice: Possible neural correlates

Lee

Gammie

2007

Pharmacology Biochemistry and Behavior

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Effects of Oxytocin on Women's Aggression Depend on State Anxiety

Campbell

Hausmann

2013

Aggressive Behavior

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(2013) 'E ects of oxytocin on women's aggression depend on state anxiety.', Aggressive behavior., 39 (4). pp. 316-322. Further information on publisher's website:https://doi.org/10.1002/ab.21478 Publisher's copyright statement: This is the accepted version of the following article: Campbell, A. and Hausmann, M. (2013), E ects of Oxytocin on Women's Aggression Depend on State Anxiety. Aggressive Behavior, 39 (4): 316-322, which has been published in nal form at https://doi.org/10.1002/ab.21478. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.Additional information: Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-pro t purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. AbstractResearch on oxytocin (OT) indicates that it has stress reducing effects. This leads to opposing predictions of decreased and increased aggression which we examine in this study. Following completion of a state anxiety measure and administration of OT or a placebo, female participants took part in a competitive aggression game (PSAP) for a monetary prize which, if won, would be paid to a loved one. In the game, three options were available: Participants could earn points; attack their opponent by deducting points; and defend themselves against point deduction by their opponent.There was no main effect of OT on these responses, however there was an interaction with state anxiety. In the placebo condition, women higher in state anxiety showed a significantly higher ratio of Attack-to-Earn responses than low anxiety women. Under oxytocin, there was a significant reduction in their Attack: Earn ratio resulting in no significant difference between high and low state anxiety groups. There was a similar trend for the Defend: Earn ratio. The reduction of reactive aggression in state anxious women supports the view that OT may decrease negative behaviour and increase constructive behaviour even under conditions of provocation.

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Telencephalic binding sites for oxytocin and social organization: A comparative study of eusocial naked mole‐rats and solitary cape mole‐rats

Κalamatianos

Faulkes

Oosthuizen

et al. 2010

J of Comparative Neurology

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African mole-rats provide a unique taxonomic group for investigating the evolution and neurobiology of sociality. The two species investigated here display extreme differences in social organization and reproductive strategy. Naked mole-rats (NMRs) live in colonies, dominated by a queen and her consorts; most members remain nonreproductive throughout life but cooperate in burrowing, foraging, and caring for pups, for which they are not biological parents (alloparenting). In contrast, Cape mole-rats (CMRs) are solitary and intolerant of conspecifics, except during fleeting seasonal copulation or minimal maternal behavior. Research on other mammals suggests that oxytocin receptors at various telencephalic sites regulate social recognition, monogamous pair bonding, and maternal/allomaternal behavior. Current paradigms in this field derive from monogamous and polygamous species of New World voles, which are evolutionarily remote from Old World mole-rats. The present findings indicate that NMRs exhibit a considerably greater level of oxytocin receptor (OTR) binding than CMRs in the: nucleus accumbens; indusium griseum; central, medial, and cortical amygdaloid nuclei; bed nucleus of the stria terminalis; and CA1 hippocampal subfield. In contrast, OTR binding in the piriform cortex is intense in CMRs but undetectable in NMRs. We speculate that the abundance of OTR binding and oxytocin-neurophysin-immunoreactive processes in the nucleus accumbens of NMRs reflects their sociality, alloparenting behavior, and potential for reproductive attachments. In contrast, the paucity of oxytocin and its receptors at this site in CMRs may reflect a paucity of prosocial behaviors. Whether similarities in OTR expression between eusocial mole-rats and monogamous voles are due to gene conservation or convergent evolution remains to be determined.

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Corticotropin-Releasing Factor Inhibits Maternal Aggression in Mice.

Cited by 117 publications

References 47 publications

GABA enhancement of maternal defense in mice: Possible neural correlates

GABA enhancement of maternal defense in mice: Possible neural correlates

Effects of Oxytocin on Women's Aggression Depend on State Anxiety

Telencephalic binding sites for oxytocin and social organization: A comparative study of eusocial naked mole‐rats and solitary cape mole‐rats

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