Corticotropin-releasing factor and schedule-induced polydipsia

Cole, Belinda J.; Koob, George F.

doi:10.1016/0091-3057(94)90134-1

Cited by 17 publications

(6 citation statements)

References 57 publications

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“…The stress coping hypothesis of SIP is, in fact, paradoxical to some extent. For example, it is not supported by a study of corticotropin‐releasing factor 32 . However, a growing body of literature published in recent years has still assumed that this paradigm could be useful, because the polydipsic character that develops in SIP seems to be an excessive manifestation of a normal primary behavior (i.e.…”

Section: Discussionmentioning

confidence: 99%

N‐methyl d‐aspartate receptors are involved in the induction, but not expression stage of amphetamine sensitization in schedule‐induced polydipsia in rats

Liu

Tung

Lin

et al. 2010

Clin Exp Pharma Physio

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1. The aim of the present study was to examine the role of dopaminergic and glutamatergic receptors on different stages of the amphetamine (AMPH) sensitized effect in schedule-induced polydipsia (SIP) in rats. 2. Three experiments were designed to evaluate the roles of DAD2 receptor antagonist haloperidol (HAL) and glutamatergic N-methyl d-aspartate receptor antagonist MK-801 on both the induction and the expression stage of AMPH sensitization in SIP rats. First, the induction of AMPH sensitization in the SIP model was tested again to confirm previous findings. Second, HAL or MK-801 was co-administered with AMPH on five consecutive days and their effect on induction was examined 14 days after withdrawal. Finally, HAL or MK-801 was co-administered with AMPH on the final day of testing in SIP rats in which AMPH sensitization had been established previously. 3. The present results showed that HAL and MK-801 affected the effect of AMPH differently during the process of sensitization. Whereas HAL influenced the sensitization during both the induction and the expression phases, MK-801 affected only the induction phase; thus, once the sensitization had been established, MK-801 had no further influence. 4. These results suggest that the SIP model could be considered useful for the study of sensitization. In addition, the induction and expression of AMPH sensitization is influenced differently by the dopaminergic and glutamatergic systems.

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Section: Discussionmentioning

confidence: 99%

N‐methyl d‐aspartate receptors are involved in the induction, but not expression stage of amphetamine sensitization in schedule‐induced polydipsia in rats

Liu

Tung

Lin

et al. 2010

Clin Exp Pharma Physio

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“…These effects are interpreted as manifestation of stress-induced diabetes mellitus (Schoenecker et al 2000) and hyper-compensatory 'pro-hedonic' response to stress (Willner 2005(Willner , 2016. They might also be associated with hypersecretion of corticotropin-releasing factor and vasopressin in hypothalamus and hypophysis (Cole and Koob 1994;Gizowski et al 2016), which provokes behavioral invigoration, stronger consumption response, and stress-induced thirst (Strekalova et al 2004(Strekalova et al , 2006. Thus, for these reasons, it is suggested that employing the sucrose preference parameter in addition to sucrose intake measure may, potentially, reduce possible distortions in the evaluation of the hedonic status of CMS rats.…”

Section: Sucrose Test and Possible Confounds In Behavioral Assessment Of Anhedoniamentioning

confidence: 99%

Chronic mild stress paradigm as a rat model of depression: facts, artifacts, and future perspectives

et al. 2022

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Rationale The chronic mild stress (CMS) paradigm was first described almost 40 years ago and has become a widely used model in the search for antidepressant drugs for major depression disorder (MDD). It has resulted in the publication of almost 1700 studies in rats alone. Under the original CMS procedure, the expression of an anhedonic response, a key symptom of depression, was seen as an essential feature of both the model and a depressive state. The prolonged exposure of rodents to unpredictable/uncontrollable mild stressors leads to a reduction in the intake of palatable liquids, behavioral despair, locomotor inhibition, anxiety-like changes, and vegetative (somatic) abnormalities. Many of the CMS studies do not report these patterns of behaviors, and they often fail to include consistent molecular, neuroanatomical, and physiological phenotypes of CMS-exposed animals. Objectives To critically review the CMS studies in rats so that conceptual and methodological flaws can be avoided in future studies. Results Analysis of the literature supports the validity of the CMS model and its impact on the field. However, further improvements could be achieved by (i) the stratification of animals into ‘resilient’ and ‘susceptible’ cohorts within the CMS animals, (ii) the use of more refined protocols in the sucrose test to mitigate physiological and physical artifacts, and (iii) the systematic evaluation of the non-specific effects of CMS and implementation of appropriate adjustments within the behavioral tests. Conclusions We propose methodological revisions and the use of more advanced behavioral tests to refine the rat CMS paradigm, which offers a valuable tool for developing new antidepressant medications.

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“…enhanced swim scores, excessive grooming, increased activity in anxiety paradigms and in other tests [121-123]. Apart from general behavioural invigoration and an increase in consumption scores, the augmentation of general liquid intake observed in chronic stress paradigms is believed to result from a stress-induced polydipsia, increased metabolic needs, diabetes mellitus and altered hormone secretion from both the hypothalamus and hypophysis [21,124,125]. Our studies revealed drastic changes in water and sucrose solution consumption as well as home cage locomotion during the course of the chronic stress procedure in C57BL/6N mice.…”

Section: Introductionmentioning

confidence: 99%

Update in the methodology of the chronic stress paradigm: internal control matters

et al. 2011

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To date, the reliability of induction of a depressive-like state using chronic stress models is confronted by many methodological limitations. We believe that the modifications to the stress paradigm in mice proposed herein allow some of these limitations to be overcome. Here, we discuss a variant of the standard stress paradigm, which results in anhedonia. This anhedonic state was defined by a decrease in sucrose preference that was not exhibited by all animals. As such, we propose the use of non-anhedonic, stressed mice as an internal control in experimental mouse models of depression. The application of an internal control for the effects of stress, along with optimized behavioural testing, can enable the analysis of biological correlates of stress-induced anhedonia versus the consequences of stress alone in a chronic-stress depression model. This is illustrated, for instance, by distinct physiological and molecular profiles in anhedonic and non-anhedonic groups subjected to stress. These results argue for the use of a subgroup of individuals who are negative for the induction of a depressive phenotype during experimental paradigms of depression as an internal control, for more refined modeling of this disorder in animals.

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Corticotropin-releasing factor and schedule-induced polydipsia

Cited by 17 publications

References 57 publications

N‐methyl d‐aspartate receptors are involved in the induction, but not expression stage of amphetamine sensitization in schedule‐induced polydipsia in rats

N‐methyl d‐aspartate receptors are involved in the induction, but not expression stage of amphetamine sensitization in schedule‐induced polydipsia in rats

Chronic mild stress paradigm as a rat model of depression: facts, artifacts, and future perspectives

Update in the methodology of the chronic stress paradigm: internal control matters

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