Corticotropin (Acth) Therapy in Guillain-Barré Syndrome

Corticosteroid use in the treatment of neuromuscular disorders: Empirical and evidence‐based data

“…Perhaps the first report was an initial clinical response to ACTH followed by a relapse that subsequently remitted following administration of cortisone 160. Other positive reports with ACTH followed,19, 117 but not all patients responded to ACTH or cortisone, and the efficacy of corticosteroid treatment of acute‐onset polyneuropathies remained controversial 82, 133. Following the recognition and separation of acute monophasic polyneuropathies from chronic and recurrent polyneuropathies, more consistent responses to ACTH and cortisone were described, including a positive placebo‐controlled trial in one patient 12…”

Landry-Guillain-Barre Syndrome: Cardiovascular Complications

“…A further eight cases were associated with specific diseases such as infectious mononucleosis or polyarteritis nodosa (Wilkins, 1953';Fiese et al, 1953 ;Plum, 1953;Plough and Ayerle, 1953;Styblova and Dejmal, 1953;Liversedge and Leather, 1953). The remaining 28 cases had the usual cLinical picture (Seltzer et al, 1952;Stillman and Ganong, 1952;Tolentino, 1952;Newey and Lubin, 1953;Blood et at., 1953 ;de Assis and Netto, 1953 ;de Assis, 1953;Senseman and Greenstein, 1953;Vernon, 1954;Lfizes, 1954;Gilsanz et al, 1954;Tupper and Foster, 1954;Essellier and Kopp, 1954;Foster and Pokorny, 1954;Guiang and Leones-Guiang, 1954;Bolt et al, 1954). Nine, of whom five had bulbar involvement, showed dramatic improvement; in 12 the progression of the disease was halted and improvement took place; and in the remainder no change occurred.…”