Corticostriatal Flow of Action Selection Bias

Hwang, Eun Jung; Link, Trevor Daniel; Hu, Yvonne Yuling; Lu, Shan; Wang, Eric Hou-Jen; Lilascharoen, Varoth; Aronson, Sage; O’Neil, Keelin; Lim, Byung Kook; Komiyama, Takaki

doi:10.1016/j.neuron.2019.09.028

Cited by 44 publications

(51 citation statements)

References 65 publications

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“…Neuronally, attraction to prior choices might result from residual activity in neuronal populations that encode prior choice, and therefore increase the probability for making the same choice again (Berlemont and Nadal, 2019). This theoretical mechanism is in accordance with animal studies that show priors and choice history activity, in posterior parietal cortex (Rao et al, 2012;Hwang et al, 2017), which might mediate subsequent biases via the basal ganglia (Lauwereyns et al, 2002;Hwang et al, 2019). Furthermore, choice, action and stimulus signals are mixed in posterior parietal cortex (Zaidel et al, 2017).…”

Section: Discussionsupporting

confidence: 73%

Perceptual decisions are biased toward relevant prior choices

Feigin

Baror

Bar

et al. 2019

Preprint

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Perceptual decisions are biased by recent perceptual history -a phenomenon termed 'serialdependence.' Using a visual location discrimination task, we investigated what aspects of perceptual decisions lead to serial dependence, and disambiguated the influences of low-level sensory information, prior choices and motor actions on subsequent perceptual decisions.Following several biased (prior) location discriminations, subsequent (test) discriminations were biased toward the prior choices, even when reported via different motor actions, and when prior and test stimuli differed in color. By contrast, biased discriminations about an irrelevant stimulus feature did not substantially influence subsequent location discriminations. Additionally, biased stimulus locations, when color was discriminated, no longer substantially influenced subsequent location decisions. Hence, the degree of relevance between prior and subsequent perceptual decisions is a key factor for serial-dependence. This suggests that serial-dependence reflects a high-level mechanism by which the brain predicts and interprets incoming sensory information in accordance with relevant prior choices.

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Section: Discussionsupporting

confidence: 73%

Perceptual decisions are biased toward relevant prior choices

Feigin

Baror

Bar

et al. 2019

Preprint

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“…These findings suggest that in PPC information on whisker movements flows across corticocortical and corticothalamic networks, through the projections of layer 2/3 and 6, respectively. Interestingly, layer 2/3 neurons in PPC project to the secondary motor cortex (M2) and control movement trajectory in a visual sensory detection task (Hwang et al, 2019). The data from Mohan et al (2019) are in line with observations that the activity in PPC precedes that in secondary motor cortex, strengthening the argument that PPC might be involved in the selection of motor outputs (Mimica et al, 2018).…”

Section: Review Of Mohan Et Alsupporting

confidence: 76%

“…The posterior parietal cortex (PPC) is extensively interconnected with sensory cortices (including barrel cortex), and frontal motor areas. The multisensory proper-ties of PPC and its connections with motor areas suggests that it might play an important role in the integration of sensory and motor signals and in guiding motor output (Mohan et al, 2018;Hwang et al, 2019). However, whisker representation in PPC as well as how PPC neurons encode information about whisker movement and touch are still poorly understood.…”

Section: Review Of Mohan Et Almentioning

confidence: 99%

Sense and Action across the Layers of the Rat Posterior Parietal Cortex

Nigro

2020

J. Neurosci.

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“…It will be valuable to determine the role of the different input pathways and to what extent they shape the rich representation found in the striatal pathways. The dorsomedial striatum receives prominent inputs from the frontal cortex, which contains key decision signals (Hwang et al, 2019;Padoa-Schioppa and Assad, 2006). The multi-tuning and multiplexing of taskrelevant signals has been observed in a number of cortical circuits (Musall et al, 2019;Steinmetz et al, 2019;Stringer et al, 2019), and some of these circuit calculations are likely to be transmitted and represented in the striatal circuitry (Peters et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Complete representation of action space and value in all striatal pathways

Weglage

Wärnberg

Lazaridis

et al. 2020

Preprint

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The dorsal striatum plays a central role in motor and decision programs, such as the selection and execution of particular actions and the evaluation of their outcomes. A standard circuit model has emerged based on the striatal organization where projection neurons with specific molecular and longrange connectivity identities encode discrete and possibly opposing action signals. We used large-scale cell-type specific imaging of calcium signals during motor and decision behaviors to map the activity of individual striatal projection neurons (SPNs) that form the three major output pathways of the striatum -SPNs in the D1+ direct, the A2A+ indirect, and the Oprm1+ patch pathway. We found that during exploration or choice behaviors SPNs showed a pathway-independent representation of the discrete phases and action variables. The tuning of individual SPNs was action and context-dependent, together covering the entire task space, and included pathway-independent representation of decisionvariables such as action value in a dynamic choice task. We propose that the three major SPN pathways broadcast in parallel the complete representation of the task space to downstream targets, including task-and phase-specific signals of action value and choice. The selection of specific actions is based on computations that produce prediction and evaluation of the action outcome, and correct action selection is essential for the survival of all species. Action selection computations have been associated with neuron activity in basal ganglia circuits, where the striatum plays a central role in integrating information from cortical and subcortical circuits, which is then propagated to downstream targets for action execution 1-3 . The striatum has been neuroanatomically divided into two major output pathways: the direct pathway targeting the globus pallidus interna (GPi) and the substantia nigra (SN), and the indirect pathway targeting the globus pallidus externa (GPe) 4,5 . A circuit model has emerged based on the dichotomous organization of the striatum, where the direct and indirect pathway differentially control motor programs and explain the pathophysiology of movement disorders 6-8 . In this model, the striatal pathways regulate motor behaviors through antagonistic signals. Neurochemical definitions can further divide the striatum into compartments 9,10 , for example into patch (also known as striosome) and matrix compartments where the striatal patches exhibit high levels of mu opioid receptor (MOR) expression 11,12 and form a distinct pathway that projects to the GPi and SN 13,14 . Distinct gene expression patterns can be used to genetically target and visualize the direct, indirect, and patch pathway 15-17 . Altogether, evidence from neuroanatomy and physiology have supported that the direct and indirect pathways have opposing effects on behavior. In support of this circuit model, optogenetic manipulation of the direct and indirect striatal pathways has shown their differential role in reinforcement as well as action [18][19][20]...

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Corticostriatal Flow of Action Selection Bias

Cited by 44 publications

References 65 publications

Perceptual decisions are biased toward relevant prior choices

Perceptual decisions are biased toward relevant prior choices

Sense and Action across the Layers of the Rat Posterior Parietal Cortex

Complete representation of action space and value in all striatal pathways

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