Corticosterone‐secreting Tumours: With and Without Renal Artery Stenosis

Mills, Ivor H.; Cook, Rosalind; Galley, Jean McI.; Edwards, O. M.; Tait, A. D.

doi:10.1111/j.1365-2265.1980.tb03396.x

Cited by 13 publications

(5 citation statements)

References 4 publications

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“…The simultaneous occurrence of adrenocortical adenoma and renovascular hypertension has been reported in a few cases (Laidlaw, Yendt and Gornerl, 1960;Hoet and Molinaeaux, 1960;Mills et al, 1980). The corrective surgery of unilateral renal artery stenosis and the operation on the secretory adrenal tumour resulted in the cure of arterial hypertension in one patient (Mills et al, 1980).…”

Section: Introductionmentioning

confidence: 96%

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Renovascular hypertension associated with bilateral aldosteronoma

Vircburger¹,

Prelević

Todorovič³

et al. 1984

Postgraduate Medical Journal

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SummaryThe authors present a 35-year-old male patient with renovascular hypertension caused by the stenosis of both renal arteries of the right kidney. Two years after the diagnosis of hypertension was made, an endarterectomy was performed but a successful correction of the upper stenotic artery was not achieved. During the next 2 years the hypertensive disease was uncontrollable with antihypertensive medications and gradually entered into a malignant phase. In addition to the atrophy of the right kidney, an adenoma of the left adrenal gland was revealed (19-75 g) which was operated on. Left adrenalectomy had only a transitory benefit on blood pressure level. Five months later an adenoma of the right adrenal gland was diagnosed and together with the ischaemic right kidney was operated on (right adrenalectomy and nephrectomy) which definitely cured the hypertension.The chronological sequence of events and the course of the disease in the patient point to the possibility that long-standing hyper-reninaemia, due to renal ischaemia, may cause the development of multiple bilateral adrenocortical adenomas and that secondary aldosteronism may transform into primary.

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Section: Introductionmentioning

confidence: 96%

“…The corrective surgery of unilateral renal artery stenosis and the operation on the secretory adrenal tumour resulted in the cure of arterial hypertension in one patient (Mills et al, 1980).…”

Section: Introductionmentioning

confidence: 98%

Renovascular hypertension associated with bilateral aldosteronoma

Vircburger¹,

Prelević

Todorovič³

et al. 1984

Postgraduate Medical Journal

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“…Spironolactone therapy resulted in marked reductions in blood pressure and normalisation of serum potassium levels. Our two cases and previous reports [7][8][9][10][11][12][13][14] suggest that clinicians should be aware that the two conditions may coexist in the same patient and that primary hyperaldosteronism may be an aetiology of resistant hypertension and/or hypokalaemia after revascularisation of renal artery stenosis.…”

Section: Introductionmentioning

confidence: 84%

“…[7][8][9][10][11][12][13][14] However, most of the cases have described the coexistence of an aldosteronoma with renovascular hypertension; only one case described unilateral adrenal hyperplasia. Complete exclusion of a small adrenal adenoma (Ͻ1.0 cm) in our two patients is not possible because they both refused adrenal vein sampling and computerised axial tomography of the adrenal glands only has about an 80% sensitivity for adenomas.…”

Section: Discussionmentioning

confidence: 99%

Coexistence of atherosclerotic renal artery stenosis with primary hyperaldosteronism

Tendler

Anwar

et al. 2000

J Hum Hypertens

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The discovery of two forms of secondary hypertension in the same patient is unusual and suggests similar pathophysiological mechanisms, a predisposition to one type in the presence of the other or a chance occurrence. We describe two patients with renal artery stenosis who after successful correction of the stenotic lesions were discovered to have primary hyperaldosteronism associated with bilateral adrenal hyperplasia. Initially prior to revascularisation of the renal artery stenosis, the diagnosis of primary hyperaldosteronism was not evident. Both patients were subjected to further

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“…However, there have been few case reports about PA associated with RVH or RAS. In fact, we have only found 18 studies published since 1960 (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) (Table 1). A few cases of APA associated with preclinical Cushing's syndrome have been reported recently (21,22).…”

Section: Introductionmentioning

confidence: 99%