Corticosterone is correlated to mediators of neural plasticity and epigenetic potential in the hippocampus of Senegalese house sparrows (Passer domesticus)

Kilvitis, Holly J.; Ardia, Daniel R.; Thiam, Massamba; Martin, Lynn B.

doi:10.1016/j.ygcen.2018.09.014

Cited by 10 publications

(2 citation statements)

References 42 publications

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“…Just as with urbanization, GC regulation is justifiably expected to be involved in range expansions [127], and some data support such relationships. House sparrows at the vanguard of range expansions across Kenya [128,129] and Senegal [130,131], for instance, regulated GCs quite differently than birds from the core of populations. A similar pattern was revealed in a southward-expanding tree swallow population relative to resident populations [132].…”

Section: Zimmer Et Al 13mentioning

confidence: 98%

HPA flexibility and FKBP5: promising physiological targets for conservation

Zimmer,

Jimeno,

Martin

2023

Preprint

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Hypothalamic-pituitary-adrenal axis (HPA) flexibility is an emerging concept recognizing that individuals that will cope best with stressors will probably be those using their hormones in the most adaptive way. The HPA flexibility concept considers glucocorticoids as molecules that convey information about the environment from the brain to the body so that the organismal phenotype comes to complement prevailing conditions. In this context, FKBP5 protein appears to set the extent to which circulating glucocorticoid concentrations can vary within and across stressors. Thus, FKBP5 expression, and the HPA flexibility it causes, seem to represent an individual’s ability to regulate its hormones to orchestrate organismal responses to stressors. As FKBP5 expression can also be easily measured in blood, it could be a worthy target of conservation-oriented research attention. We first review the known and likely roles of HPA flexibility and FKBP5 in wildlife. We then describe putative genetic, environmental, and epigenetic causes of variation in HPA flexibility and FKBP5 expression among- and within-individuals. Finally, we hypothesize how HPA flexibility and FKBP5 expression should affect organismal fitness and hence population viability in response to human-induced rapid environmental changes, particularly urbanization.

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Section: Zimmer Et Al 13mentioning

confidence: 98%

HPA flexibility and FKBP5: promising physiological targets for conservation

Zimmer,

Jimeno,

Martin

2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Just as with urbanization, GC regulation is justifiably expected to be involved in range expansions [128], and some data support such relationships. House sparrows at the vanguard of range expansions across Kenya [129,130] and Senegal [131,132], for instance, regulated GCs quite differently from birds from the core of populations. A similar pattern was revealed in a southward-expanding tree swallow population relative to resident populations [133].…”

Section: Causes Of Variation In Endocrine Flexibility and Fkbp5mentioning

confidence: 99%

HPA flexibility and FKBP5 : promising physiological targets for conservation

Zimmer,

Jimeno,

Martin

2024

Phil. Trans. R. Soc. B

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Hypothalamic–pituitary–adrenal axis (HPA) flexibility is an emerging concept recognizing that individuals that will cope best with stressors will probably be those using their hormones in the most adaptive way. The HPA flexibility concept considers glucocorticoids as molecules that convey information about the environment from the brain to the body so that the organismal phenotype comes to complement prevailing conditions. In this context, FKBP5 protein appears to set the extent to which circulating glucocorticoid concentrations can vary within and across stressors. Thus, FKBP5 expression, and the HPA flexibility it causes, seem to represent an individual's ability to regulate its hormones to orchestrate organismal responses to stressors. As FKBP5 expression can also be easily measured in blood, it could be a worthy target of conservation-oriented research attention. We first review the known and likely roles of HPA flexibility and FKBP5 in wildlife. We then describe putative genetic, environmental and epigenetic causes of variation in HPA flexibility and FKBP5 expression among and within individuals. Finally, we hypothesize how HPA flexibility and FKBP5 expression should affect organismal fitness and hence population viability in response to human-induced rapid environmental changes, particularly urbanization. This article is part of the theme issue ‘Endocrine responses to environmental variation: conceptual approaches and recent developments’.

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Transposons as Environmental Stress Detectors, Are Eukaryotic Genomes Evolved to Evolve?

Hunter

2024

Epigenetics in Biological Communication

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Corticosterone is correlated to mediators of neural plasticity and epigenetic potential in the hippocampus of Senegalese house sparrows (Passer domesticus)

Cited by 10 publications

References 42 publications

HPA flexibility and FKBP5: promising physiological targets for conservation

HPA flexibility and FKBP5: promising physiological targets for conservation

HPA flexibility and FKBP5 : promising physiological targets for conservation

Transposons as Environmental Stress Detectors, Are Eukaryotic Genomes Evolved to Evolve?

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