Corticosterone impairs contextual fear recall after reactivation in the ovariectomized rat model of menopause

Kashefi, Adel; Rashidy-Pour, Ali; Vafaei, Abbas Ali; Haghparast, Abbas; Tomaz, Carlos; Ahmadalipour, Ali

doi:10.1016/j.bbr.2020.112817

Cited by 2 publications

(1 citation statement)

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“…Corticosterone, a stress hormone, the main glucocorticoids released from hypothalamus-pitutary-adrenal (HPA) axis. Recently studies indicated that Corticosterone was elevated in mice that received mild stress at a neurobiological level (Fuentes-Verdugo et al, 2020), and others showed that Corticosterone impairs the recall of strong contextual fear memory after reactivation in the ovariectomized rat model of menopause (Kashefi et al, 2020). Importantly, BAI not only significantly reduced the levels of 21-Hydroxypregnenolone, Serotonin, 8,9-DiHETrE, Dihydrofolic acid, and Dihydrocortisol in the gut, but also increased the abundance ofBlautia and Fournierella and the associated metabolites 2-oxoarginine in the chickens suffered colibacillosis.…”

Section: Discussionmentioning

confidence: 99%

Baicalin protects against APEC-induced colibacillosis by regulating gut microbiota and its metabolites in Chickens

Peng¹,

Shi²,

Gong³

et al. 2020

Preprint

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BACKGROUND AND PURPOSE Chicken colibacillosis, caused by avian Escherichia coli (APEC), results in huge economic losses to the poultry industry. Baicalin exerts protective effects during the development of colibacillosis. In this study, we mainly explored the mechanism of this protective effects with regard to gut microbiota. EXPERIMENTAL APPROACH The chicken colibacillosis model was established by intratracheal instillation of APEC. The gut microbiota-depleted chicken model was established with broad-spectrum antibiotics. Viscera index measurement and Haematoxylin and eosin stain were applied to assess histological changes of tissues. ELISA were used to measure the cytokines and Quantitative-PCR were used to evaluate the gene expression. The gut microbiota and its metabolite were detected by 16srDNA and ultrahigh-performance liquid chromatography (LC-MS). KEY RESULTS Depletion of gut microbiota exacerbated the tissue damage and weakened the protective effects of baicalin during APEC-induced chicken colibacillosis while pretreatment of baicalin reduced these changes and inflammatory response induced by APEC. Moreover, APEC infection led to dysbiosis of gut microbiota and its metabolites. However, the pretreatment of baicalin remodeled the gut microbiota featured with increased abundance of Intestinimonas and its associated with beneficial metabolites. CONCLUSIONS Gut microbiota played a protective role in the prevention of chicken colibacillosis and the pharmacological action of baicalin. The altered specific gut bacterial and/or metabolites may be served as indicators to predict the occurrence and prognosis of chicken colibacillosis. Our findings may provide a paradigm for the mechanistic studies of compounds and aid the exploration of the mechanisms and pathways underlying the function of herbal medicines.

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Section: Discussionmentioning

confidence: 99%