Corticosterone down-regulates dopamine D4 receptor in a mouse cerebral cortex neuronal cell line

Barros, Virginia G.; Boado, Lorena A.; Adamo, Ana M.; Caviedes, Raúl; Caviedes, Pablo; Antonelli, Marta C.

doi:10.1007/bf03033156

Cited by 8 publications

(3 citation statements)

References 27 publications

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“…Another hypothesis suggested that prenatal stress‐induced corticosterone secretion can act directly alter dopamine receptors (Lammers et al, 1999). However, our recent results showed that corticosterone inhibited D 4 receptor (member of the DA D 2 ‐like receptors) expression in immortalized cell lines from cerebral cortex of normal mouse fetuses (Barros et al, 2003), suggesting that overexpression of DA D 2 receptors in prenatally stressed offspring is not directly promoted by corticosterone.…”

Section: Discussionmentioning

confidence: 94%

Early adoption modifies the effects of prenatal stress on dopamine and glutamate receptors in adult rat brain

Barros

Berger

Martijena

et al. 2004

J of Neuroscience Research

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Stressful stimuli during pregnancy induce complex effects that influence the development of offspring. These effects can be prevented by environmental manipulations during the early postnatal period. Repeated restraint during the last week of pregnancy was used as a model of prenatal stress, and adoption at birth was used to change the postnatal environment. No differences were found in various physical landmarks, except for testis descent, for which all prenatally stressed pups showed a 1-day delay in comparison with control rats, regardless of the postnatal adoption procedure. Levels of dopamine (DA) D(2) and glutamate (Glu) N-methyl-D-aspartate (NMDA) receptors were differentially regulated in different forebrain regions of cross-fostered adult offspring. Increased concentrations of cortical D(2) receptors detected in stressed pups, raised by a gestationally stressed biological mother, were not detected when the pups were raised by a control mother. Control pups raised by a foster mother whether gestationally stressed or not had higher levels of NMDA receptors in cortical areas. These findings suggest that the normal expression of DA and Glu receptors is influenced by in utero experience and by lactation. The complex pattern of receptor changes reflects the high vulnerability of DA and Glu systems to variations both in prenatal and in postnatal environment, particularly for cortical D(2) receptors and NMDA receptors in cerebral cortex and nucleus accumbens. In contrast, testis descent appears to be more susceptible to prenatal than to postnatal environmental events.

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Section: Discussionmentioning

confidence: 94%

Early adoption modifies the effects of prenatal stress on dopamine and glutamate receptors in adult rat brain

Barros

Berger

Martijena

et al. 2004

J of Neuroscience Research

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“…The existing data on ADHD suggest that alterations in dopaminergic signaling due to pyrethroid insecticide exposure influences ADHD pathogenesis and are important for studying ADHD risk [41,51]. Chronic stress exposure also alters the dopamine system and could further potentiate the risk of ADHD [60,87,94,95,96]. Given the independent effects of pyrethroid insecticides and chronic stress on the dopamine system, we hypothesized that combined pyrethroid insecticide and stress hormone exposure during critical periods of neurodevelopment would additively alter protein expression and the function of key components of the dopamine system, thereby further increasing the risk of developing ADHD.…”

Section: Discussionmentioning

confidence: 99%

A Neurodevelopmental Model of Combined Pyrethroid and Chronic Stress Exposure

Vester

Chen

Marsit

et al. 2019

Toxics

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Attention-deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders of childhood and previous studies indicate the dopamine system plays a major role in ADHD pathogenesis. Two environmental exposures independently associated with dopaminergic dysfunction and ADHD risk include exposure to deltamethrin, a pyrethroid insecticide, and chronic stress. We hypothesized that combined neurodevelopmental exposure to both deltamethrin and corticosterone (CORT), the major stress hormone in rodents, would result in additive changes within the dopamine system. To study this, we developed a novel dual exposure paradigm and exposed pregnant C57BL/6 dams to 3 mg/kg deltamethrin through gestation and weaning, and their offspring to 25 μg/mL CORT dissolved in the drinking water through adulthood. Midbrain RNA expression as well as striatal and cortical protein expression of key dopaminergic components were investigated, in addition to ADHD-like behavioral tasks and electrochemical dopamine dynamics via fast-scan cyclic voltammetry. Given the well-described sexual dimorphism of ADHD, males and females were assessed separately. Males exposed to deltamethrin had significantly decreased midbrain Pitx3 expression, decreased cortical tyrosine hydroxylase (TH) expression, increased activity in the Y maze, and increased dopamine uptake rate in the dorsal striatum. These effects did not occur in males exposed to CORT only, or in males exposed to both deltamethrin and CORT, suggesting that CORT may attenuate these effects. Additionally, deltamethrin- and CORT-exposed females did not display these dopaminergic features, which indicates these changes are sex-specific. Our results show dopaminergic changes from the RNA through the functional level. Moreover, these data illustrate the importance of testing multiple environmental exposures together to better understand how combined exposures that occur in certain vulnerable populations could affect similar neurodevelopmental systems, as well as the importance of studying sex differences of these alterations.

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“…The expression of Drd4 was reduced by CORT treatment in a neuronal cell line (Barros et al, 2003). However, how Drd4 expression was impeded by stress exposure and the resultant elevation of CORT levels remained unknown thus far.…”

Section: Npas4-drd4 Axis Controlled By Cortmentioning

confidence: 99%

Npas4-mediated dopaminergic regulation of fear memory states

Yoo

Choi

et al. 2022

Preprint

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Amygdala circuitry encodes associations between conditioned stimuli and aversive unconditioned stimuli, and also controls fear expression (Pape and Pare, 2010). However, whether and how irrelevant information for unpaired conditioned stimuli (CS-) is discretely processed, and how it was influenced by stress remain unknown. CS- memory is retrievable immediately after fear conditioning, but then becomes silent after memory consolidation in mice. Synaptic pathway from the lateral to the anterior basal amygdala gates the expression of CS- memory, depending upon Npas4-mediated Drd4 synthesis. The upregulation of Npas4-Drd4 axis, which is precluded by corticosterone, shifts functional states of neural engrams for CS- memory toward silent states and limits its retrievability. In here, we demonstrate the cellular and molecular mechanisms regulating the functional states of neural engrams, which can be switched or maintained, supporting discriminative memory.

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Corticosterone down-regulates dopamine D4 receptor in a mouse cerebral cortex neuronal cell line

Cited by 8 publications

References 27 publications

Early adoption modifies the effects of prenatal stress on dopamine and glutamate receptors in adult rat brain

Early adoption modifies the effects of prenatal stress on dopamine and glutamate receptors in adult rat brain

A Neurodevelopmental Model of Combined Pyrethroid and Chronic Stress Exposure

Npas4-mediated dopaminergic regulation of fear memory states

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