Corticosterone binding to hippocampus: Immediate and delayed influences of the absence of adrenal secretion

McEwen, Bruce S.; Wallach, Gislaine; Magnus, Carew

doi:10.1016/0006-8993(74)90321-7

Cited by 123 publications

(34 citation statements)

References 17 publications

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“…In the absence of corticosteroid hormones (ADX), binding of labelled corticosterone initially (up to 11 hr) rises, indicating that the endogenous hormone no longer occupies the receptors which then become available for the exogenously administered ligand (McEwen et al, 1974). A second rise in steroid binding sites starts at 18 hr after ADX; this rise probably represents steroid-dependent changes in MRs and GRs.…”

Section: Homologous Regulationmentioning

confidence: 99%

Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems

Joëls

Kloet

1994

Progress in Neurobiology

368

168

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Section: Homologous Regulationmentioning

confidence: 99%

Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems

Joëls

Kloet

1994

Progress in Neurobiology

368

168

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“…For example, restraint, swim, or audiogenic stress in rats resulted in c-fos induction in neocortex, allocortex, hippocampus, nucleus accumbens, lateral septum, hypothalamus, amygdala, dorsal raphe, locus coeruleus, and brain-stem nuclei (Campeau and Watson, 1997;Cullinan et al, 1995;1996). The integration of the brain and endocrine stress response is mediated via the limbic-hypothalamic-pituitary-adrenal axis (Selye, 1936;McEwen et al, 1974), the activation of which results in a series of events leading to glucocorticoid release. There is growing evidence that chronic elevations of glucocorticoids may cause damage to limbic brain regions (Kaufman et al, 2000;McEwen, 2000;Sapolsky, 2000).…”

Section: Regions With Decreased Glucose Metabolism Are Functionally Cmentioning

confidence: 99%

Local Brain Functional Activity Following Early Deprivation: A Study of Postinstitutionalized Romanian Orphans

et al. 2001

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“…Baseline blood samples were taken within 3 min of entering bird rooms (Romero and Reed, 2005). After 30 min of restraint in a cloth bag, a stress-induced blood sample was also taken.To reduce endogenous CORT that would otherwise interfere with receptor binding assays (Breuner et al, 2000;McEwen et al, 1974), all house sparrows in both control and stressed groups received intramuscular injections of mitotane (ortho, para-DDD; 180 mg kg −1 body mass; SigmaAldrich, St Louis, MO, USA) ~36 and ~24 h prior to euthanization (Breuner and Orchinik, 2001). The first mitotane injection was given immediately after sampling blood for baseline and stress-induced CORT.…”

mentioning

confidence: 99%

Chronic stress alters concentrations of corticosterone receptors in a tissue-specific manner in wild house sparrows (Passer domesticus)

Lattin

Romero

2014

Journal of Experimental Biology

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The physiological stress response results in release of glucocorticoid hormones such as corticosterone (CORT). Whereas short-term activation of this response helps animals cope with environmental stressors, chronic activation can result in negative effects including metabolic dysregulation and reproductive failure. However, there is no consensus hormonal profile of a chronically stressed animal, suggesting that researchers may need to look beyond hormone titers to interpret the impacts of chronic stress. In this study, we brought wild house sparrows (Passer domesticus) into captivity. We then compared glucocorticoid and mineralocorticoid receptor concentrations in sparrows exposed either to a standardized chronic stress protocol (n=26) or to standard husbandry conditions (controls; n=20). We used radioligand binding assays to quantify receptors in whole brain, liver, kidneys, spleen, gonads, gastrocnemius and pectoralis muscle, omental and subcutaneous fat, and bib and back skin. In most tissues, CORT receptors did not differ between controls and stressed animals, although we found marginal increases in receptor density in kidney and testes in stressed birds at some time points. Only in pectoralis muscle was there a robust effect of chronic stress, with both receptor types higher in stressed animals. Increased pectoralis sensitivity to CORT with chronic stress may be part of the underlying mechanism for muscle wasting in animals administered exogenous CORT. Furthermore, the change in pectoralis was not paralleled by gastrocnemius receptors. This difference may help explain previous reports of a greater effect of CORT on pectoralis than on other muscle types, and indicate that birds use this muscle as a protein reserve. KEY WORDS: Hypothalamic-pituitary-adrenal axis, Glucocorticoids, Peripheral receptors, Bird INTRODUCTIONActivation of the hypothalamus-pituitary-adrenal (HPA) axis results in the release of glucocorticoid hormones (cortisol and/or corticosterone depending on the species, hereafter CORT). At baseline concentrations, CORT helps regulate metabolism, activity levels and feeding behavior; at the higher concentrations caused by a stressor, CORT is an essential component of the vertebrate stress response (Landys et al., 2006;Sapolsky et al., 2000). During the stress response, CORT helps animals mobilize energy stores, enhances certain immune components and promotes escape and selfmaintenance behaviors (Spencer et al., 2001;Wingfield and Kitaysky, 2002). RESEARCH ARTICLEDepartment of Biology, Tufts University, Medford, MA 02155, USA.*Author for correspondence (christine.lattin@tufts.edu) Received 7 February 2014; Accepted 26 April 2014However, sustained high levels of CORT due to frequent or prolonged stressors can result in a number of stress-related pathologies, including suppression of reproduction and the immune system, metabolic dysregulation and cognitive impairment (Dallman et al., 2003; de Kloet et al., 2005;Martin, 2009;Sapolsky et al., 2000). Chronic stress is thought to result once COR...

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Corticosterone binding to hippocampus: Immediate and delayed influences of the absence of adrenal secretion

Cited by 123 publications

References 17 publications

Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems

Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems

Local Brain Functional Activity Following Early Deprivation: A Study of Postinstitutionalized Romanian Orphans

Chronic stress alters concentrations of corticosterone receptors in a tissue-specific manner in wild house sparrows (Passer domesticus)

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