Corticosterone and insulin interact to regulate glucose and triglyceride levels during stress in a bird

Remage‐Healey, Luke; Romero, L. Michael

doi:10.1152/ajpregu.2001.281.3.r994

Cited by 126 publications

(87 citation statements)

References 38 publications

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“…Only one steroid hormone was delivered per experiment. Hormone doses were based on previous studies in which steroid levels were experimentally manipulated to achieve short-term changes in circulating plasma levels of cortisol (Veillette et al, 1995;Remage-Healey and Romero, 2001;Wood et al, 2001), 11KT (Townsend et al, 1991;Bar et al, 1996;Watanuki et al, 2002), 17␤-estradiol (Salbert et al, 1993;Olsson and Kling, 1995), and testosterone (Townsend et al, 1991;Joubert and Tobin, 1995;Bar et al, 1996;McAllan et al, 1998). After hormone or vehicle injection, a subsequent series of vocal motor recordings were obtained at 5,15,30,45,60,90, and 120 min.…”

Section: Methodsmentioning

confidence: 99%

Rapid, Hierarchical Modulation of Vocal Patterning by Steroid Hormones

Remage‐Healey¹,

Bass²

2004

J. Neurosci.

158

140

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Vocal control systems have been identified in all major groups of jawed vertebrates. Although steroid hormones are instrumental in the long-term development and maintenance of neural structures underlying vocalization, it is unknown whether steroids rapidly modulate the neural activity of vocal motor systems. The midshipman fish generates advertisement and agonistic calls that mainly differ in duration. A descending midbrain pathway activates a hindbrain-spinal vocal circuit that directly establishes the discharge frequency and duration of the rhythmic vocal motor volley. This vocal motor output, which can be monitored from occipital nerve roots, directly determines the rate and duration of contraction of a pair of sonic muscles and, in turn, the fundamental frequency and duration of vocalizations. Here, we demonstrate that the duration of the vocal motor volley, or fictive vocalization, is rapidly responsive to steroid hormones, including androgens, estrogens, and glucocorticoids. These responses are consistent, in part, with a nongenomic mechanism and are steroid specific at the receptor level, suggesting the possibility of multiple membrane-bound receptor populations. We also show, using intact and semi-intact preparations, that steroids hierarchically modulate fictive vocalizations; whereas the hindbrain-spinal region is both necessary and sufficient for rapid (within 5 min) effects on duration, descending midbrain input is necessary for maintenance (up to 120 min) of these effects. The conserved nature of vertebrate vocal motor systems suggests that the neuroendocrine principles outlined in this study may be a fundamental feature of all vocal vertebrates.

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Section: Methodsmentioning

confidence: 99%

Rapid, Hierarchical Modulation of Vocal Patterning by Steroid Hormones

Remage‐Healey¹,

Bass²

2004

J. Neurosci.

158

140

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“…Based on our findings on HPA responsiveness, we would have expected differences in glucose stress responses in post-natally treated females. However, other systems or hormones, such as the autonomic nervous system or insulin, may co-operate with the HPA axis in the control of blood glucose release in response to stress (Havel and Taborsky, 1989;Remage-Healey and Romero, 2001). Finally, we pointed out that at day PN22 glucose increased at the end of the restraint in all birds, regardless of treatment.…”

Section: Pre-and Post-natal Effects Of Corticosterone On Basal and Stmentioning

confidence: 99%

“…High glucocorticoid concentrations in early life may induce changes in stress and metabolic responses that can help developing individuals to deal with stressful circumstances in the short-term, but can have costs later in life (Gluckman et al, 2007;Cottrell and Seckl, 2009). Glucose may be a good candidate for investigating the above links as (1) several vertebrates, including birds, can increase circulating glucose levels in response to acute stress (Oller Do Nascimento Curi et al, 1990;Widmaier and Kunz, 1993;Carragher and Rees, 1994;Remage-Healey and Romero, 2000;Remage-Healey and Romero, 2001); and (2) long-term elevation of glucocorticoids is involved in glucose mobilisation and basal metabolism (Norris, 1997).…”

Section: Introductionmentioning

confidence: 99%

Pre- and post-natal stress in context: effects on the stress physiology in a precocial bird

Marasco

Robinson

Herzyk

et al. 2012

Journal of Experimental Biology

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SUMMARYDevelopmental stress can significantly influence physiology and survival in many species. Mammalian studies suggest that preand post-natal stress can have different effects (i.e. hyper-or hypo-responsiveness) on the hypothalamic-pituitary-adrenal (HPA) axis, the main mediator of the stress response. In mammals, the physiological intimacy between mother and offspring constrains the possibility to control, and therefore manipulate, maternal pre-and post-natal influences. Here, using the Japanese quail (Coturnix coturnix japonica) as our model, we elevated levels of the glucocorticoid stress hormone corticosterone in ovo and/or in the endogenous circulation of hatchlings. We examined the effects of treatments on corticosterone and glucose stress responses at two different ages, in juvenile and adult quail. In juveniles, corticosterone data revealed a sex-specific effect of postnatal treatment regardless of the previous pre-natal protocol, with post-natally treated females showing shorter stress responses in comparison with the other groups, while no differences were observed among males. In adulthood, birds previously stressed as embryos showed higher corticosterone concentrations over the stress response compared with controls. This effect was not evident in birds subjected to either post-natal treatment or the combined treatments. There were no effects on glucose in the juveniles. However, adult birds previously stressed in ovo showed opposite sex-specific basal glucose patterns compared with the other groups. Our results demonstrate that (1) early glucocorticoid exposure can have both transient and long-term effects on the HPA axis, depending upon the developmental stage and sex and (2) post-natal stress can modulate the effects of pre-natal stress on HPA activity.

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“…Moreover, CORT and insulin generally antagonistically regulate circulating glucose concentrations Kaplan, 1996;Strack et al, 1995). In birds, typical CORT and insulin functions are maintained throughout a capture-restraint stress response (Remage-Healey and Romero, 2001). However, heat stress seems to de-couple this counter-regulatory relationship between glucocorticoids and insulin in many mammals.…”

Section: Introductionmentioning

confidence: 99%

Hormonal and metabolic responses to upper temperature extremes in divergent life-history ecotypes of a garter snake

Gangloff

Holden

Telemeco

et al. 2016

Journal of Experimental Biology

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Extreme temperatures constrain organismal physiology and impose both acute and chronic effects. Additionally, temperature-induced hormone-mediated stress response pathways and energetic tradeoffs are important drivers of life-history variation. This study employs an integrative approach to quantify acute physiological responses to high temperatures in divergent life-history ecotypes of the western terrestrial garter snake (Thamnophis elegans). Using wild-caught animals, we measured oxygen consumption rate and physiological markers of hormonal stress response, energy availability and anaerobic respiration in blood plasma across five ecologically relevant temperatures (24, 28, 32, 35 and 38°C; 3 h exposure). Corticosterone, insulin and glucose concentrations all increased with temperature, but with different thermal response curves, suggesting that high temperatures differently affect energy-regulation pathways. Additionally, oxygen consumption rate increased without plateau and lactate concentration did not increase with temperature, challenging the recent hypothesis that oxygen limitation sets upper thermal tolerance limits. Finally, animals had similar physiological thermal responses to high-temperature exposure regardless of genetic background, suggesting that local adaptation has not resulted in fixed differences between ecotypes. Together, these results identify some of the mechanisms by which higher temperatures alter hormonal-mediated energy balance in reptiles and potential limits to the flexibility of this response.

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Corticosterone and insulin interact to regulate glucose and triglyceride levels during stress in a bird

Cited by 126 publications

References 38 publications

Rapid, Hierarchical Modulation of Vocal Patterning by Steroid Hormones

Rapid, Hierarchical Modulation of Vocal Patterning by Steroid Hormones

Pre- and post-natal stress in context: effects on the stress physiology in a precocial bird

Hormonal and metabolic responses to upper temperature extremes in divergent life-history ecotypes of a garter snake

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