Corticosterone and chlorpyrifos oxon exposure elicits spatiotemporal MAPK phosphoprotein signaling in a mouse brain

Penatzer, Julia A.; Prince, Nicole; Miller, Julie V.; Newman, Mackenzie; Lynch, Cayla; Hobbs, Gerald R.; Boyd, Jonathan

doi:10.1016/j.fct.2021.112421

Cited by 2 publications

(2 citation statements)

References 57 publications

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“…Some of the reasons for suicide attempt included work-related stress and an additional 17% were occupational exposures [ 166 ]. Another study found that a biomarker of stress, corticosterone, increased neuroinflammation in rat brains, suggesting an important role of workplace stress [ 107 ]. These studies point to the classic chicken and egg situation because they cannot unravel the possibility for pesticide exposure to impact mental health which then impacts pesticide safety behaviors and effects of pesticides in the brain.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Brain Health in Agricultural Work: A Systematic Review

Sturm

Castro

Mendez-Colmenares

et al. 2022

IJERPH

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Certain exposures related to agricultural work have been associated with neurological disorders. To date, few studies have included brain health measurements to link specific risk factors with possible neural mechanisms. Moreover, a synthesis of agricultural risk factors associated with poorer brain health outcomes is missing. In this systematic review, we identified 106 articles using keywords related to agriculture, occupational exposure, and the brain. We identified seven major risk factors: non-specific factors that are associated with agricultural work itself, toluene, pesticides, heavy metal or dust exposure, work with farm animals, and nicotine exposure from plants. Of these, pesticides are the most highly studied. The majority of qualifying studies were epidemiological studies. Nigral striatal regions were the most well studied brain area impacted. Of the three human neuroimaging studies we found, two focused on functional networks and the third focused on gray matter. We identified two major directions for future studies that will help inform preventative strategies for brain health in vulnerable agricultural workers: (1) the effects of moderators such as type of work, sex, migrant status, race, and age; and (2) more comprehensive brain imaging studies, both observational and experimental, involving several imaging techniques.

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Section: Discussionmentioning

confidence: 99%

Risk Factors for Brain Health in Agricultural Work: A Systematic Review

Sturm

Castro

Mendez-Colmenares

et al. 2022

IJERPH

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“…For instance, various pesticides (such as herbicides, CPF, profenofos, ethion, and malathion) and other toxic agrochemical substances can directly impact neural systems ( 144 ). The global use of toxic agrochemicals such as pesticides in agriculture has increased due to their cost-effectiveness, high efficiency, and easy accessibility ( 145 ). Evidence indicates that factors influence pesticide exposure levels such as duration of farm work, mixing multiple highly toxic pesticides, personal spraying habits and hygiene practices at work sites, and inadequate use of PPE ( 146–148 ).…”

Section: Discussionmentioning

confidence: 99%

Profile and risk factors in farmer injuries: a review based on Haddon matrix and 5 E’s risk reduction strategy

Qi,

Yao,

Cong

et al. 2024

Front. Public Health

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Farmers are considered a high-risk group for intentional and unintentional injuries. This review identified significant risk factors for agricultural injuries in farmers and explored injury prevention countermeasures based on the literature. Therefore, CiteSpace software was used to analyze the relevant literature in this field. Additionally, we identified both key risk factors and countermeasures using the Haddon matrix and the 5 E’s risk reduction strategies conceptual framework, respectively. The risk factors were identified from four categories (host, agent, physical environment, and social environment) corresponding to three phases (pre-event, event, and post-event). Interventions of 5 E’s risk reduction strategies including education, engineering, enforcement, economic, and emergency response have been proven effective in preventing injuries or reducing their severity. Our findings provide a comprehensive foundation and research direction for the study and prevention of injuries among farmers.

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Corticosterone and chlorpyrifos oxon exposure elicits spatiotemporal MAPK phosphoprotein signaling in a mouse brain

Cited by 2 publications

References 57 publications

Risk Factors for Brain Health in Agricultural Work: A Systematic Review

Risk Factors for Brain Health in Agricultural Work: A Systematic Review

Profile and risk factors in farmer injuries: a review based on Haddon matrix and 5 E’s risk reduction strategy

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