Corticosterone - an anxiogenic or an anxiolytic agent?

File, Sandra E.; Vellucci, Sandra V.; Wendlandt, S

doi:10.1111/j.2042-7158.1979.tb13505.x

Cited by 87 publications

(33 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results, as well as work by others (10)(11)(12)(13), suggest that corticosterone also can be behaviorally active. In the present study the behavioral effects of corticosterone were measured 6.5-9.5 h after injection, therefore, these behavioral effects may be mediated through either genomic actions of corticosterone or perhaps more rapid nongenomic actions, such as effects on cell membranes (13) or on other neurochemical systems.…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

The effects of stress on social preferences are sexually dimorphic in prairie voles.

DeVries

Taymans

et al. 1996

Proc. Natl. Acad. Sci. U.S.A.

211

182

View full text Add to dashboard Cite

Prairie voles (Microtus ochrogaster) are monogamous rodents that form pair bonds characterized by a preference for a familiar social partner. In male prairie voles, exposure to either the stress of swimming or exogenous injections of corticosterone facilitate the development of a social preference for a female with which the male was paired after injection or swimming. Conversely, adrenalectomy inhibits partner preference formation in males and the behavioral effects of adrenalectomy are reversed by corticosterone replacement. In female prairie voles, swim stress interferes with the development of social preferences and corticosterone treatments inhibit the formation of partner preferences, while adrenalectomized females form preferences more quickly than adrenally intact controls. Because sex differences in both behavior and physiology are typically reduced in monogamous species, we initially predicted that male and female prairie voles would exhibit similar behavioral responses to corticosterone. However, our findings suggest an unanticipated sexual dimorphism in the physiological processes modulating social preferences. This dimorphic involvement of stress hormones in pair bonding provides a proximate mechanism for regulating social organization, while permitting males and females to adapt their reproductive strategies in response to environmental challenges.

show abstract

Section: Discussionsupporting

confidence: 90%

“…Adrenal hormones, including corticosterone, can influence exploratory behavior (10,11) and social interactions (12) in male rats. However, in the present study, overall movement did not differ between experimental animals and controls, suggesting that the observed differences were not secondary to changes in locomotor activity.…”

Section: Discussionmentioning

confidence: 99%

The effects of stress on social preferences are sexually dimorphic in prairie voles.

DeVries

Taymans

et al. 1996

Proc. Natl. Acad. Sci. U.S.A.

211

182

View full text Add to dashboard Cite

show abstract

“…In another example, mimicking the reduction in HPA axis activity in adulthood caused by early deprivation, early subjugation and non-social peripubertal stressors (through adrenalectomy with low-level glucocorticoid replacement) 72 led to decreased social behaviors and antisociality. This was abolished by repeated glucocorticoid treatments 73,74 suggesting that the long-term suppression of HPA-axis function and the altered social behavior in these models are causally related. Therefore, both excesses and deficits in glucocorticoid production have detrimental effects on social behavior.…”

Section: Effects Of Manipulating Glucocorticoid Levelsmentioning

confidence: 91%

Stress and the social brain: behavioural effects and neurobiological mechanisms

2015

View full text Add to dashboard Cite

“…Notably, serotonergic systems within the caudal dorsal raphe nucleus and median raphe nucleus give rise to collateral projections to the CA1 region of the hippocampus and entorhinal cortex (Kohler and Steinbusch, 1982). Finally, it is possible that the increase in activity is due to input from hormonal signals, such as glucocorticoid hormones, which have been implicated in the regulation of anxiety-related behavior and anxiety states (File et al, 1979).…”

Section: Discussionmentioning

confidence: 99%

Exposure to an open-field arena increases c-Fos expression in a distributed anxiety-related system projecting to the basolateral amygdaloid complex

et al. 2008

View full text Add to dashboard Cite

Anxiety states and anxiety-related behaviors appear to be regulated by a distributed and highly interconnected system of brain structures including the basolateral amygdala. Our previous studies demonstrate that exposure of rats to an open-field in high-and low-light conditions results in a marked increase in c-Fos expression in the anterior part of the basolateral amygdaloid nucleus (BLA) compared to controls. The neural mechanisms underlying the anatomically specific effects of openfield exposure on c-Fos expression in the BLA are not clear, however, it is likely that this reflects activation of specific afferent input to this region of the amygdala. In order to identify candidate brain regions mediating anxiety-induced activation of the basolateral amygdaloid complex in rats, we used Cholera Toxin B subunit (CTb) as a retrograde tracer to identify neurons with direct afferent projections to this region in combination with c-Fos immunostaining to identify cells responding to exposure to an open-field arena in low-light (8-13 lux) conditions (an anxiogenic stimulus in rats). Adult male Wistar rats received a unilateral microinjection of 4% CTb in phosphate-buffered saline into the basolateral amygdaloid complex. Rats were housed individually for 11 days after CTb injections and handled for 2 min each day. On the test day rats were either, 1) exposed to an openfield in low-light conditions (8-13 lux) for 15 minutes; 2) briefly handled or 3) left undisturbed (control). We report that dual immunohistochemical staining for c-Fos and CTb revealed an increase in the percentage of c-Fos-immunopositive basolateral amygdaloid complex-projecting neurons in open-field-exposed rats compared with handled and control rats in the ipsilateral CA1 region of the ventral hippocampus, subiculum and lateral entorhinal cortex. These data are consistent with the hypothesis that exposure to the open-field arena activates an anxiety-related neuronal system with convergent input to the basolateral amygdaloid complex.

show abstract

Corticosterone - an anxiogenic or an anxiolytic agent?

Cited by 87 publications

References 24 publications

The effects of stress on social preferences are sexually dimorphic in prairie voles.

The effects of stress on social preferences are sexually dimorphic in prairie voles.

Stress and the social brain: behavioural effects and neurobiological mechanisms

Exposure to an open-field arena increases c-Fos expression in a distributed anxiety-related system projecting to the basolateral amygdaloid complex

Contact Info

Product

Resources

About