Corticosterone administration to rat pups, but not maternal separation, affects sexual maturation and glucocorticoid receptor immunoreactivity in the testis

Biagini, Giuseppe; Pich, Emilio Merlo

doi:10.1016/s0091-3057(02)00754-2

Cited by 30 publications

(27 citation statements)

References 50 publications

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“…These observations suggest that the proposed prenatal stress‐induced blockade of testosterone surge, which normally occurs between days 18 and 19 of gestation (Ward and Weisz, 1984), is probably the key factor that controls testis descent and is not altered by postnatal environment. Biagini and Pich (2002) found that another postnatal procedure, such as maternal separation, did not modify time to testis descent. In addition, daily stress episodes of maternal deprivation were not sufficient to affect the development of reproductive functions in the rat (Lau et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

Early adoption modifies the effects of prenatal stress on dopamine and glutamate receptors in adult rat brain

Barros

Berger

Martijena

et al. 2004

J of Neuroscience Research

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Stressful stimuli during pregnancy induce complex effects that influence the development of offspring. These effects can be prevented by environmental manipulations during the early postnatal period. Repeated restraint during the last week of pregnancy was used as a model of prenatal stress, and adoption at birth was used to change the postnatal environment. No differences were found in various physical landmarks, except for testis descent, for which all prenatally stressed pups showed a 1-day delay in comparison with control rats, regardless of the postnatal adoption procedure. Levels of dopamine (DA) D(2) and glutamate (Glu) N-methyl-D-aspartate (NMDA) receptors were differentially regulated in different forebrain regions of cross-fostered adult offspring. Increased concentrations of cortical D(2) receptors detected in stressed pups, raised by a gestationally stressed biological mother, were not detected when the pups were raised by a control mother. Control pups raised by a foster mother whether gestationally stressed or not had higher levels of NMDA receptors in cortical areas. These findings suggest that the normal expression of DA and Glu receptors is influenced by in utero experience and by lactation. The complex pattern of receptor changes reflects the high vulnerability of DA and Glu systems to variations both in prenatal and in postnatal environment, particularly for cortical D(2) receptors and NMDA receptors in cerebral cortex and nucleus accumbens. In contrast, testis descent appears to be more susceptible to prenatal than to postnatal environmental events.

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Section: Discussionmentioning

confidence: 99%

Early adoption modifies the effects of prenatal stress on dopamine and glutamate receptors in adult rat brain

Barros

Berger

Martijena

et al. 2004

J of Neuroscience Research

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“…The mechanism considered responsible for these phenomena are sex steroids produced by the adrenal cortex (i.e., progesterone and oestrogens). Administration of corticosterone was also found to advance pubertal maturation in male rats (Biagini and Pich, 2002). As such, it has been proposed that while corticosterone may not have a direct effect on reproductive development, its interactions with gonadotrophins, such as LH and FSH are likely to facilitate early sexual maturation (Rivest, 1991).…”

Section: Hpa Axis Activity Throughout Developmentmentioning

confidence: 99%

Neonatal immune challenge alters reproductive development in the female rat

Sominsky

Meehan

Walker

et al. 2012

Hormones and Behavior

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“…The percentage of TW/BW in all treated groups showed no significant difference when compared with the control group. However, there has been a report that testicular weight in rat pups is increased when exposed to 10 mg kg −1 of corticosterone, a stress hormone, for 38 days after birth (Biagini & Pich, ). On the other hand, rat testicular weight was decreased after high dose serotonin administration over 4 days (Hedger et al ., ).…”

Section: Discussionmentioning

confidence: 99%

Recovery effect of pre-germinated brown rice on the alteration of sperm quality, testicular structure and androgen receptor expression in rat model of depression

2016

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Depression and antidepressant drugs induce adverse effects in male reproduction. Therefore, it is important to investigate alternative treatment for depression without adverse effects on the male reproductive system. The aim of this study was to determine the effect of pre-germinated brown rice (PGBR) on sperm quality, testicular structure and androgen receptor (AR) expression in rat model of depression. Male Sprague Dawley rats were divided into five groups including control (distilled water only), depression induced by forced swimming test (FST), FST + fluoxetine (antidepressant drug), FST + GABA (gamma-aminobutyric acid) (standard) and FST + PGBR. When compared with the control, sperm motility showed a significant decrease in FST + fluoxetine group. Sperm morphology also decreased significantly in depression and FST + fluoxetine groups. The morphological changes of seminiferous tubules showed significant increases in depression and FST + fluoxetine groups, while AR expression showed significant decreases in depression, FST + fluoxetine and FST + GABA groups. Interestingly, there were no significant differences in all sperm quality parameters, testicular structure and AR expression in FST + PGBR group. These findings reflect the recovery effects of PGBR treatment on sperm quality, morphological changes of seminiferous tubules and AR expression in stress-induced rats. Therefore, PGBR may potentially develop for the treatment for depression without adverse effect on male reproduction.

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Corticosterone administration to rat pups, but not maternal separation, affects sexual maturation and glucocorticoid receptor immunoreactivity in the testis

Cited by 30 publications

References 50 publications

Early adoption modifies the effects of prenatal stress on dopamine and glutamate receptors in adult rat brain

Early adoption modifies the effects of prenatal stress on dopamine and glutamate receptors in adult rat brain

Neonatal immune challenge alters reproductive development in the female rat

Recovery effect of pre-germinated brown rice on the alteration of sperm quality, testicular structure and androgen receptor expression in rat model of depression

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