Corticosteroids for acute severe asthma in hospitalised patients

Manser, Renée; Reid, David W.; Abramson, Michael J.

doi:10.1002/14651858.cd001740

Cited by 120 publications

(102 citation statements)

References 35 publications

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“…Subgroup analysis of patients with oral or intravenous corticosteroids was not done because it was shown that corticosteroids administered orally and intravenously had similar efficacy in the treatment of adult with acute asthma 23,24 . Moreover, the subgroup analysis of different dosages was also not done because it was shown that higher doses do not appear to be more effective for acute asthma 21 .…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, a Cochrane review showed that use of systemic corticosteroids within 1 hour of presentation to an emergency department can significantly reduce the need for hospital admission in patients with acute asthma 17 . Also, systemic corticosteroids can help to reduce the rate of relapse; and thus, it should be administered to patients with severe asthma [18][19][20][21] .…”

Section: Introductionmentioning

confidence: 99%

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Commencement of systemic corticosteroids in emergency Department versus in ward in management of acute adult asthma requiring hospitalization: a retrospective cohort study

Yim

2016

Bangladesh J Med Sci

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Introduction: Systemic corticosteroids are commonly used in management of acute asthma, sometimes started before admission in emergency department, sometimes in ward after admission. This study is to determine whether commencing systemic corticosteroids in emergency department compared to in ward for managing acute adult asthma requiring hospitalization can improve the outcome: shorter length of hospital stay. Methods: A retrospective cohort study was conducted in an emergency department in Hong Kong. Adults aged 18 to 65 years-old who presented to the emergency department with acute asthma and subsequently hospitalized with use of systemic corticosteroids were recruited and divided into two groups: a group with commencement of systemic corticosteroids in emergency department (Group A, n=139) and the other group with commencement of systemic corticosteroids in ward (Group B, n=209). The outcome measurement was length of hospital stay. Results: A total of 348 subjects were recruited in final analyses. We used Mann-Whitney U test to test the difference in ranking of length of hospital stay (days) between these two groups. The mean rank of length of hospital stay in Group A was 159, and that in Group B was 185 (p=0.014). The difference was statistically significant with commencement of systemic corticosteroids in emergency department resulting in higher ranking-shorter length of hospital stay. Conclusion: It may be possible to result in earlier discharge in acute adult asthma requiring hospitalization when systemic corticosteroids is started before admission in emergency department, instead of in ward after admission.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Commencement of systemic corticosteroids in emergency Department versus in ward in management of acute adult asthma requiring hospitalization: a retrospective cohort study

Yim

2016

Bangladesh J Med Sci

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“…[367][368][369] (Evidence A). Where possible, systemic corticosteroids should be administered to the patient within 1 hour of presentation.…”

Section: Systemic Corticosteroidsmentioning

confidence: 99%

Mortality in Asthma-Chronic Obstructive Pulmonary Disease Overlap in the United States

Kumbhare

Strange

2018

Southern Medical Journal

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“…[19,20] Oral steroids are as effective as intravenous therapy, and preferable because of their ease of administration, cost-effectiveness and fewer side-effects. [21][22][23] The recommended dose of oral prednisone or prednisolone is 1 mg/kg/d, i.e. 20 mg in children aged 2 -5 years and 30 -40 mg in children aged >5 years.…”

Section: Steroid Therapymentioning

confidence: 99%