Corticosteroid treatment regulates mucosal remodeling in chronic rhinosinusitis with nasal polyps

Callejas, Francisco de Borja; Martínez-Antón, Asunción; Picado, César; Alobid, Isam; Pujols, Laura; Valero, Antonio; Roca‐Ferrer, Jordi; Mullol, Joaquim

doi:10.1002/lary.25147

Cited by 30 publications

(28 citation statements)

References 40 publications

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“…Jiang et al () found that MMP‐7 levels were elevated in patients with oral squamous cell carcinoma. de Borja Callejas et al () have proposed that MMP‐7 may be involved in the formation and remodeling of nasal polyps based on an observed level of expression of MMP‐7 in nasal polyps. They also determined treatment with corticosteroids could be a viable option in regulation the remodeling of the mucosal layer when dealing with rhinosinusitis associated nasal polyps (de Borja Callejas et al, ).…”

Section: Matrix Metalloproteinase‐7mentioning

confidence: 99%

Intricate Functions of Matrix Metalloproteinases in Physiological and Pathological Conditions

Mittal

Patel

Debs

et al. 2016

Journal Cellular Physiology

143

115

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Matrix metalloproteinases (MMPs) are a diverse group of proteolytic enzymes and play an important role in the degradation and remodeling of the extracellular matrix (ECM). In normal physiological conditions, MMPs are usually minimally expressed. Despite their low expression, MMPs have been implicated in many cellular processes ranging from embryological development to apoptosis. The activity of MMPs is controlled at three different stages: (1) transcription; (2) zymogen activation; and (3) inhibition of active forms by tissue inhibitor metalloproteinases (TIMPs). They can collectively degrade any component of ECM and basement membrane, and their excessive activity has been linked to numerous pathologies mainly including, but not limited to, tumor invasion and metastasis. The lack of information about several MMPs and the steady stream of new discoveries suggest that there is much more to be studied in this field. In particular, there is a need for controlling their expression in disease states. Various studies over the past 30 years have found that each MMP has a specific mode of activation, action, and inhibition. Drugs specifically targeting individual MMPs could revolutionize the treatment of a great number of health conditions and tremendously reduce their burden. In this review article, we have summarized the recent advances in understanding the role of MMPs in physiological and pathological conditions. J. Cell. Physiol. 231: 2599-2621, 2016. © 2016 Wiley Periodicals, Inc.

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Section: Matrix Metalloproteinase‐7mentioning

confidence: 99%

Intricate Functions of Matrix Metalloproteinases in Physiological and Pathological Conditions

Mittal

Patel

Debs

et al. 2016

Journal Cellular Physiology

143

115

View full text Add to dashboard Cite

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“…Epithelial hyperplasia is also seen in lower airway diseases such as cystic fibrosis and COPD. de Borja Callejas et al . demonstrated that oral corticosteroids led to modulation in epithelial remodeling in nasal polyposis, with decreased epithelial hyperplasia and tissue eosinophilia.…”

Section: The Majority Of Chinese Nps Are Neutrophilicmentioning

confidence: 99%

Smoking is an independent association of squamous metaplasia in Chinese nasal polyps

Gao

et al. 2015

Int Forum Allergy Rhinol

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“…4 Use of oral corticosteroid treatment with combined intranasal corticosteroid treatment has been shown to modulate nasal polyp mucosa remodeling through promotion of epithelial repair, regulation of tissue remodeling markers, increasing collagen content, and reducing tissue eosinophil infiltration. 5 Short courses of oral corticosteroids in CRSwNP are associated with significant reduction in polyp size as well as improved CRS symptom scores, nasal endoscopy, and magnetic resonance imaging findings. 6 However, given the heterogeneity of CRS, the presence of nasal polyps as the sole determining factor for oral steroid may be too simplistic and may not account for patients with overlapping or difficult to classify disease.…”

Section: Introductionmentioning

confidence: 95%

“…Oral steroids are recommended for perioperative use among patients with CRSwNP and allergic fungal sinusitis . Use of oral corticosteroid treatment with combined intranasal corticosteroid treatment has been shown to modulate nasal polyp mucosa remodeling through promotion of epithelial repair, regulation of tissue remodeling markers, increasing collagen content, and reducing tissue eosinophil infiltration . Short courses of oral corticosteroids in CRSwNP are associated with significant reduction in polyp size as well as improved CRS symptom scores, nasal endoscopy, and magnetic resonance imaging findings .…”

Section: Introductionmentioning

confidence: 99%

The presence of eosinophil aggregates correlates with increased postoperative prednisone requirement

Tajudeen¹,

Ganti

Kuhar

et al. 2018

The Laryngoscope

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Objectives/Hypothesis Failure after sinus surgery is multifactorial, but often due to recurrence of inflammatory mucosal disease. Postoperative steroid requirements for controlling mucosal inflammation may provide insight into predicting which patients require more aggressive medical therapy to prevent disease relapse. Study Design Retrospective chart review. Methods A review was performed of patients who underwent functional endoscopic sinus surgery (FESS) for refractory chronic rhinosinusitis (CRS). Sino‐Nasal Outcome Test‐22 scores and cumulative prednisone dose (milligrams) requirements at 1, 3, and 6 months postoperatively were reviewed. A structured histopathology report of 11 variables was accessed to correlate histopathology with postoperative steroid requirements. Results One hundred one patients were reviewed including 42 CRS with nasal polyps and 59 CRS without nasal polyps patients. CRS patients with eosinophilia required greater cumulative steroids to control disease at 1‐, 3‐, and 6‐month postoperative intervals (P < .026, P < .007, P < .013, respectively) compared to patients without eosinophilia. Patients with tissue eosinophil aggregates required the highest cumulative steroids at 1‐, 3‐, and 6‐month postoperative intervals (P < .003, P < .001, P < .001, respectively). When removing patients with eosinophil aggregates from the eosinophilia group, no difference persisted between patients with eosinophilia and those without eosinophilia at all intervals (P = .664, P = .735, P = .800, respectively). No other histopathology variable correlated with postoperative steroid requirement. Conclusions Tissue eosinophil aggregates appear to be the largest driving factor for increased prednisone requirements after sinus surgery to control mucosal disease than mere presence of eosinophils. This key finding may identify patients at high risk for failure after sinus surgery and guide more proactive postoperative management. Level of Evidence 4 Laryngoscope, 129:794–799, 2019

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Corticosteroid treatment regulates mucosal remodeling in chronic rhinosinusitis with nasal polyps

Abstract: 4

Cited by 30 publications

References 40 publications

Intricate Functions of Matrix Metalloproteinases in Physiological and Pathological Conditions

Intricate Functions of Matrix Metalloproteinases in Physiological and Pathological Conditions

Smoking is an independent association of squamous metaplasia in Chinese nasal polyps

The presence of eosinophil aggregates correlates with increased postoperative prednisone requirement

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