Corticosteroid Treatment in Autoimmune Encephalitis

Sunwoo, Jae Gun

doi:10.18700/jnc.170029

Cited by 2 publications

(1 citation statement)

References 100 publications

(67 reference statements)

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“…In situations where the etiology is unclear, such as autoimmunity vs. infection, an empirical steroid might aggravate the infection. In addition, steroids can be ineffective against antibodymediated immune diseases, [37][38][39] and so their efficacy in each type of autoimmune encephalitis needs to be investigated systemically. Also, the psychologic side effects of corticosteroids such as delirium, depressive mood, anxiety, and sleep deprivation can also interfere the ability of the clinician to accurately judge the treatment response.…”

Section: Protocol For Immunotherapiesmentioning

confidence: 99%

Clinical Approach to Autoimmune Epilepsy

et al. 2020

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Autoimmune epilepsy is a newly emerging area of epilepsy. The concept of “autoimmune” as an etiology has recently been revisited thanks to advances in autoimmune encephalitis and precision medicine with immunotherapies. Autoimmune epilepsy presents with specific clinical manifestations, and various diagnostic approaches including cerebrospinal fluid analysis, neuroimaging, and autoantibody tests are essential for its differential diagnosis. The diagnosis is often indeterminate despite performing a thorough evaluation, and therefore empirical immunotherapy may be applied according to the judgment of the clinician. Autoimmune epilepsy often manifests as new-onset refractory status epilepticus (NORSE). A patient classified as NORSE should receive empirical immunotherapy as soon as possible. On the other hand, a morecautious, stepwise approach is recommended for autoimmune epilepsy that presents with episodic events. The type of autoimmune epilepsy is also an important factor to consider when choosing from among various immunotherapy options. Clinicians should additionally take the characteristics of antiepileptic drugs into account when using them as an adjuvant therapy. This expert opinion discusses the diagnostic and treatment approaches for autoimmune epilepsy from a practical point of view.

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Section: Protocol For Immunotherapiesmentioning

confidence: 99%

Clinical Approach to Autoimmune Epilepsy

et al. 2020

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Diagnosis and treatment-related issues of autoimmune epilepsy

Шилкина

Timechko

Дмитренко

2023

Èpilepsiâ paroksizmalʹnye sostoâ.

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Due to elevated frequency of autoimmune epilepsy cases, the issues related to reliable clinical and laboratory-instrumental criteria for establishing the disease etiology become relevant. Differentiated assessment of autoantibody markers allows to choose the most effective tactics for managing patients. The article presents the criteria for assessing autoimmune epilepsy as well as diagnostic scales, features related to clinical picture and response to therapy based on the type of synthesized autoantibodies. Therapeutic lines and targets for immunomodulatory and antiepileptic drugs used in autoimmune epilepsy are detailed, the knowledge of which along with clinical and laboratory data collectively allow to determine effective and safe therapy algorithm.

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Corticosteroid Treatment in Autoimmune Encephalitis

Cited by 2 publications

References 100 publications

Clinical Approach to Autoimmune Epilepsy

Clinical Approach to Autoimmune Epilepsy

Diagnosis and treatment-related issues of autoimmune epilepsy

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