Corticosteroid therapy for refractory infections in chronic granulomatous disease: case reports and review of the literature

Yamazaki‐Nakashimada, Marco Antonio; Stiehm, E. Richard; Pietropaolo-Cienfuegos, Dino; Hernández-Bautista, Víctor Manuel; Espinosa-Rosales, Francisco

doi:10.1016/s1081-1206(10)60023-3

Cited by 40 publications

(41 citation statements)

References 24 publications

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“…However, it is well known that fungi can cause tremendous inflammatory response in lungs [10]. Corticosteroids are recommended for inflammatory complications even in invasive infections [12]. We used low dose corticosteroid in Case 2 with limited improvement in respiratory symptoms.…”

Section: Discussionmentioning

confidence: 99%

Necrotizing Liver Granuloma/Abscess and Constrictive Aspergillosis Pericarditis with Central Nervous System Involvement: Different Remarkable Phenotypes in Different Chronic Granulomatous Disease Genotypes

Akarcan

Karaca

Aksu

et al. 2017

Case Reports in Immunology

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Chronic granulomatous disease (CGD) is a primary immune deficiency causing predisposition to infections with specific microorganisms, Aspergillus species and Staphylococcus aureus being the most common ones. A 16-year-old boy with a mutation in CYBB gene coding gp91phox protein (X-linked disease) developed a liver abscess due to Staphylococcus aureus. In addition to medical therapy, surgical treatment was necessary for the management of the disease. A 30-month-old girl with an autosomal recessive form of chronic granulomatous disease (CYBA gene mutation affecting p22phox protein) had invasive aspergillosis causing pericarditis, pulmonary abscess, and central nervous system involvement. The devastating course of disease regardless of the mutation emphasizes the importance of early diagnosis and intervention of hematopoietic stem cell transplantation as soon as possible in children with CGD.

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Section: Discussionmentioning

confidence: 99%

Necrotizing Liver Granuloma/Abscess and Constrictive Aspergillosis Pericarditis with Central Nervous System Involvement: Different Remarkable Phenotypes in Different Chronic Granulomatous Disease Genotypes

Akarcan

Karaca

Aksu

et al. 2017

Case Reports in Immunology

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“…Corticosteroids typically have been used in gastrointestinal and obstructive complications. However, corticosteroids have also been used in addition to antimicrobials to treat refractory infections in CGD, and they are able to suppress inflammation in MAS [22,23]. It is important to note that microbiologic diagnosis is essential to rule out antibiotic failure [23].…”

Section: Discussionmentioning

confidence: 99%

“…It is important to note that microbiologic diagnosis is essential to rule out antibiotic failure [23]. This aspect is important because corticosteroids and immunosuppressants can exacerbate infection if the patient is without optimal antimicrobial coverage [22,23]. On the other hand, experts suggest that there has to be a balance between halting progressing microbial infection and controlling damaging inflammation in CGD [20].…”

Section: Discussionmentioning

confidence: 99%

Intravenous Immunoglobulin Treatment for Macrophage Activation Syndrome Complicating Chronic Granulomatous Disease

et al. 2011

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“…Treatment with corticosteroids in addition to antifungals can be life saving. Other reports have included successful treatment of inoperable liver abscesses (one without a pathogen identified, others with S. aureus ), combined Bukholderia cepacia and Aspergillus pneumonia, and a pneumonia with effusion with several bacterial isolates 5–7 .…”

Section: Discussionmentioning

confidence: 99%

Corticosteroids in the Treatment of Severe Nocardia Pneumonia in Chronic Granulomatous Disease

Freeman¹,

Marciano²,

Anderson³

et al. 2011

Pediatric Infectious Disease Journal

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Nocardia is one of five main pathogens that infect chronic granulomatous disease (CGD) patients. Despite aggressive antimicrobial therapy, medical treatment is not always successful and surgical resection of infected tissue has been intermittently required. We present two CGD patients with severe Nocardia pneumonia whose pulmonary status worsened despite appropriate antimicrobials, but then improved clinically and radiographically with the addition of corticosteroids.

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Corticosteroid therapy for refractory infections in chronic granulomatous disease: case reports and review of the literature

Cited by 40 publications

References 24 publications

Necrotizing Liver Granuloma/Abscess and Constrictive Aspergillosis Pericarditis with Central Nervous System Involvement: Different Remarkable Phenotypes in Different Chronic Granulomatous Disease Genotypes

Necrotizing Liver Granuloma/Abscess and Constrictive Aspergillosis Pericarditis with Central Nervous System Involvement: Different Remarkable Phenotypes in Different Chronic Granulomatous Disease Genotypes

Intravenous Immunoglobulin Treatment for Macrophage Activation Syndrome Complicating Chronic Granulomatous Disease

Corticosteroids in the Treatment of Severe Nocardia Pneumonia in Chronic Granulomatous Disease

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