Corticosteroid receptors in liver cytosol of the clawed toad, Xenopus laevis: Influence of thyroid and ovarian hormones

Lange, CA; Hanke, W.; Morishige, Walter K.

doi:10.1016/0016-6480(89)90206-2

Cited by 3 publications

(1 citation statement)

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“…Rapid nongenomic actions of GCs have also been proposed for mammals, avian, fish, and amphibians (Borski, ; Breuner & Orchinik, ; Evans, Murray, & Moore, ; Evanson, Herman, Sakai, & Krause, ; Jiang, Liu, & Tasker, ; Orchinik, Matthews, & Gasser, ; Orchinik, Murray, & Moore, ). The GR intracellular receptors for GCs have been described in several organs such as liver, kidney, skin, and testis (Denari & Ceballos, ; Lange & Hanke, ; Lange, Hanke, & Morishige, ; Orchinik et al, ; Regueira, Sassone, Scaia, Volonteri, & Ceballos, ). In the anuran Rhinella arenarum , GR has been shown to be activated by corticosterone, the most abundant GC synthesized by the interrenal gland of this species (Ceballos, Cozza, & Lantos, ).…”

Section: Introductionmentioning

confidence: 99%

Effect of glucocorticoids on androgen biosynthesis in the testes of the toad Rhinella arenarum (Amphibia, Anura)

et al. 2018

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In rat Leydig cells, glucocorticoids (GCs) inhibit testosterone production through the interaction with the glucocorticoid receptor (GR). However, the sensitivity of those cells to GCs is regulated by the enzyme 11β-hydroxysteroid dehydrogenase Type 1 (11β-HSD1). In the testes of the toad Rhinella arenarum, the presence of an 11β-HSD similar to type 2 and a cytosolic GR has also been described. However, there is a lack of information regarding the effects of GCs on amphibian testicular steroidogenesis. In this study, the effects of corticosterone on androgen production, and the activity of two steroidogenic enzymes in toad testes were reported. Corticosterone inhibits androgen production via the GR because the GR antagonist RU486 prevents corticosterone-induced inhibition of testosterone. Corticosterone also reduced the activity of the cytochrome P450 17-hydroxylase, C17,20-lyase (Cyp450 ) without affecting the 3β-hydroxysteroid dehydrogenase/isomerase activity. This effect on Cyp450 was likewise inhibited by RU486. On the other hand, corticosterone had no effect on the amount of steroidogenic acute regulator protein. These results suggest that GCs inhibit steroidogenesis in toad testes by reducing of Cyp450 activity via a GR-mediated mechanism.

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