Corticosteroid and Antihistamine Modification of Bleomycin-lnduced Fever

Oken, Martin M.; Loch, J.

doi:10.3181/00379727-161-40603

Cited by 4 publications

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“…Pyrogen assay. The techniques used for injection and temperature monitoring of rabbits were as previously described (13). Supernatants from a stated number of monocytes constituted a single test dose.…”

Section: Methodsmentioning

confidence: 99%

Endogenous pyrogen production by human blood monocytes stimulated by staphylococcal cell wall components

Oken¹,

Peterson²,

Wilkinson³

1981

Infect Immun

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To determine the properties of Staphylococcus aureus contributing to its pyrogenicity, we compared, in human monocytes, endogenous pyrogen production stimulated by heat-killed S. aureus with that stimulated by purified S. aureus cell walls or by particulate peptidoglycan prepared from the same strain. Peptidoglycan, but not the purified cell wall preparation, was found comparable to S. aureus as an endogenous pyrogen stimulus. This finding was associated with a more effective monocyte phagocytosis of S. aureus and peptidoglycan as compared with that of purified cell walls. Lysostaphin digestion of peptidoglycan markedly reduced its pyrogenicity. To test whether the chemical composition of the ingested particles is important, latex particles were tested as possible stimuli for monocyte endogenous pyrogen release. Although 40 to 68% of monocytes ingested latex particles during the first hour, there was no evidence of endogenous pyrogen activity in the supernatant even when supernatants equivalent to 5.2 x 106 monocytes were tested. This study demonstrates that the pyrogenic moiety of the S. aureus cell wall resides in the peptidoglycan component. Phagocytosis is not in itself a pyrogenic stimulus, but rather serves as an effective mechanism to bring about contact between the chemical stimulus and the monocyte.

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Section: Methodsmentioning

confidence: 99%

Endogenous pyrogen production by human blood monocytes stimulated by staphylococcal cell wall components

Oken¹,

Peterson²,

Wilkinson³

1981

Infect Immun

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Hydroxyalkylation of parabanic acid. II. Reactions of parabanic acid with oxiranes

Zarzyka‐Niemiec¹,

Lubczak²

2004

J of Applied Polymer Sci

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ABSTRACT:Reactions of parabanic acid with ethylene oxide, propylene oxide, or glycerin epichlorohydrin were studied at the initial molar ratios of reagent ranging from 1 : 1 to 1 : 8. The effects of catalyst presence and temperature on the course of reaction were analyzed. The conditions were established at which the parabanic acid ring was preserved and those at which it opened to form polymeric products.

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Role of Central Neurotransmitters in Fever

Cox¹,

Lee²

1982

Pyretics and Antipyretics

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Corticosteroid and Antihistamine Modification of Bleomycin-lnduced Fever

Abstract: Supported by research funds from the Veterans Administration.Address all correspondence to: Martin M. Oken, M.D., Hematology Section, V.A. Hospital, 54th St. and 48th Ave. So., Minneapolis, Minn. 55417.

Cited by 4 publications

References 0 publications

Endogenous pyrogen production by human blood monocytes stimulated by staphylococcal cell wall components

Endogenous pyrogen production by human blood monocytes stimulated by staphylococcal cell wall components

Hydroxyalkylation of parabanic acid. II. Reactions of parabanic acid with oxiranes

Role of Central Neurotransmitters in Fever

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