Corticospinal Excitability is Dependent on the Parameters of Peripheral Electric Stimulation: A Preliminary Study

Chipchase, Lucinda S; Schabrun, Siobhan M; Hodges, Paul W.

doi:10.1016/j.apmr.2011.01.011

Cited by 84 publications

(100 citation statements)

References 54 publications

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“…These MEP alterations have been proposed depending on the intensity (Chipchase et al, 2011a; Schabrun et al, 2012), frequency (Mang et al, 2010; Golaszewski et al, 2012), and duration (Andrews et al, 2013) of PES. Studies have also shown alterations in TMS-evoked MEPs following PES without concomitant changes in brainstem electrical stimulation-evoked MEPs (Kaelin-Lang et al, 2002) or electrical stimulation-evoked M- and F-waves, or H-reflex (Tinazzi et al, 2005; Mang et al, 2010; Golaszewski et al, 2012), suggesting that the observed modulation occurs at the cortical level.…”

Section: Introductionmentioning

confidence: 99%

Presence and Absence of Muscle Contraction Elicited by Peripheral Nerve Electrical Stimulation Differentially Modulate Primary Motor Cortex Excitability

Sasaki

Kotan

Nakagawa

et al. 2017

Front. Hum. Neurosci.

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Modulation of cortical excitability by sensory inputs is a critical component of sensorimotor integration. Sensory afferents, including muscle and joint afferents, to somatosensory cortex (S1) modulate primary motor cortex (M1) excitability, but the effects of muscle and joint afferents specifically activated by muscle contraction are unknown. We compared motor evoked potentials (MEPs) following median nerve stimulation (MNS) above and below the contraction threshold based on the persistence of M-waves. Peripheral nerve electrical stimulation (PES) conditions, including right MNS at the wrist at 110% motor threshold (MT; 110% MNS condition), right MNS at the index finger (sensory digit nerve stimulation [DNS]) with stimulus intensity approximately 110% MNS (DNS condition), and right MNS at the wrist at 90% MT (90% MNS condition) were applied. PES was administered in a 4 s ON and 6 s OFF cycle for 20 min at 30 Hz. In Experiment 1 (n = 15), MEPs were recorded from the right abductor pollicis brevis (APB) before (baseline) and after PES. In Experiment 2 (n = 15), M- and F-waves were recorded from the right APB. Stimulation at 110% MNS at the wrist evoking muscle contraction increased MEP amplitudes after PES compared with those at baseline, whereas DNS at the index finger and 90% MNS at the wrist not evoking muscle contraction decreased MEP amplitudes after PES. M- and F-waves, which reflect spinal cord or muscular and neuromuscular junctions, did not change following PES. These results suggest that muscle contraction and concomitant muscle/joint afferent inputs specifically enhance M1 excitability.

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Section: Introductionmentioning

confidence: 99%

Presence and Absence of Muscle Contraction Elicited by Peripheral Nerve Electrical Stimulation Differentially Modulate Primary Motor Cortex Excitability

Sasaki

Kotan

Nakagawa

et al. 2017

Front. Hum. Neurosci.

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“…For example, MEP amplitude increases after ES at 50 Hz at the intensity of the sensory threshold, after ES at 2 Hz at the intensity of the MT for 30 min (Golaszewski et al, 2012) and after intermittent ES at 10 Hz for 2 h (Kaelin-Lang et al, 2002). Conversely, some studies (Murakami et al, 2007; Chipchase et al, 2011a) have indicated that MEP amplitude decreases after ES. ES above MT is considered to increase corticomotor excitability, whereas ES below MT produces conflicting results (Chipchase et al, 2011b).…”

Section: Discussionmentioning

confidence: 94%

“…This effect persists for >30 min after the cessation of ES (Khaslavskaia and Sinkjaer, 2005). In contrast, Chipchase et al, 2011a) evaluated the effects of six ES paradigms on M1 excitability and showed that only repetitive ES in an on–off mode (cycles of 4 s on and 6 s off) for 30 min results in increasing M1 excitability. Moreover, they showed that M1 excitability decreases slightly when continuous ES is applied for 30 min at an intensity below the motor threshold (MT).…”

Section: Introductionmentioning

confidence: 99%

Depression of corticomotor excitability after muscle fatigue induced by electrical stimulation and voluntary contraction

Kotan

Kojima

Miyaguchi

et al. 2015

Front. Hum. Neurosci.

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In this study, we examined the effect of muscle fatigue induced by tetanic electrical stimulation (ES) and submaximal isometric contraction on corticomotor excitability. Experiments were performed in a cross-over design. Motor-evoked potentials (MEPs) were elicited by transcranial magnetic stimulation (TMS). Corticomotor excitability was recorded before and after thumb opposition muscle fatigue tasks, in which 10% of the maximal tension intensity was induced by tetanic ES or voluntary contraction (VC). The participants were 10 healthy individuals who performed each task for 10 min. Surface electrodes placed over the abductor pollicis brevis (APB) muscle recorded MEPs. F- and M-waves were elicited from APB by supramaximal ES of the median nerve. After the tetanic ES- and VC tasks, MEP amplitudes were significantly lower than before the task. However, F- and M-wave amplitudes remained unchanged. These findings suggest that corticospinal excitability is reduced by muscle fatigue as a result of intracortical inhibitory mechanisms. Our results also suggest that corticomotor excitability is reduced by muscle fatigue caused by both VC and tetanic ES.

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“…The largest increases in MEP were obtained by treatment durations of up to 30 min (Chang et al, 2011;Chipchase et al, 2011;Khaslavskaia et al, 2002;Knash et al, 2003;Ridding et al, 2000). In contrast, a decline in MEP for a short period in healthy humans was observed at low intensity (below the motor threshold) and high frequency (200 Hz) (Chipchase et al, 2011). Therefore, we proposed that delivery of NMES with low pulse frequency and above motor threshold intensity might promote the low cortical excitability in the patients with SCA.…”

Section: Introductionmentioning

confidence: 87%

“…In previous studies, an increase in MEP in healthy humans was produced by NMES with low pulse frequency (10-25 Hz) and high intensity (up to and above the motor threshold) (Chang et al, 2011;Chipchase et al, 2011;Khaslavskaia et al, 2002;Knash et al, 2003;Ridding et al, 2000). The largest increases in MEP were obtained by treatment durations of up to 30 min (Chang et al, 2011;Chipchase et al, 2011;Khaslavskaia et al, 2002;Knash et al, 2003;Ridding et al, 2000). In contrast, a decline in MEP for a short period in healthy humans was observed at low intensity (below the motor threshold) and high frequency (200 Hz) (Chipchase et al, 2011).…”

Section: Introductionmentioning

confidence: 98%

Neuromuscular electrical stimulation of the median nerve facilitates low motor cortex excitability in patients with spinocerebellar ataxia

Chen¹,

Chuang²,

Yang³

et al. 2015

Journal of Electromyography and Kinesiology

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The neuromodulation of motor excitability has been shown to improve functional movement in people with central nervous system damage. This study aimed to investigate the mechanism of peripheral neuromuscular electrical stimulation (NMES) in motor excitability and its effects in people with spinocerebellar ataxia (SCA). This single-blind case-control study was conducted on young control (n=9), age-matched control (n=9), and SCA participants (n=9; 7 SCAIII and 2 sporadic). All participants received an accumulated 30 min of NMES (25 Hz, 800 ms on/800 ms off) of the median nerve. The central motor excitability, measured by motor evoked potential (MEP) and silent period, and the peripheral motor excitability, measured by the H-reflex and M-wave, were recorded in flexor carpi radialis (FCR) muscle before, during, and after the NMES was applied. The results showed that NMES significantly enhanced the MEP in all 3 groups. The silent period, H-reflex and maximum M-wave were not changed by NMES. We conclude that NMES enhances low motor excitability in patients with SCA and that the mechanism of the neuromodulation was supra-segmental. These findings are potentially relevant to the utilization of NMES for preparation of motor excitability. The protocol was registered at Clinicaltrials.gov (NCT02103075).

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Corticospinal Excitability is Dependent on the Parameters of Peripheral Electric Stimulation: A Preliminary Study

Cited by 84 publications

References 54 publications

Presence and Absence of Muscle Contraction Elicited by Peripheral Nerve Electrical Stimulation Differentially Modulate Primary Motor Cortex Excitability

Presence and Absence of Muscle Contraction Elicited by Peripheral Nerve Electrical Stimulation Differentially Modulate Primary Motor Cortex Excitability

Depression of corticomotor excitability after muscle fatigue induced by electrical stimulation and voluntary contraction

Neuromuscular electrical stimulation of the median nerve facilitates low motor cortex excitability in patients with spinocerebellar ataxia

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