Corticospinal excitability after 5-day Dry Immersion in women

Abstract

In light of the development of manned astronautics and the increasing participation of women in space flights, the question of female body adaptation to microgravity conditions becomes relevant. Currently, one of the important directions in this issue is to study the effects of support withdrawal as a factor of weightlessness on the human sensorimotor system. Dry Immersion is one of the well-known ground-based models, which adequately reproduces the main physiological effects of space flight. The aim of this study was to evaluate the changes in motor evoked potentials of the lower leg gravity-dependent muscles in women after a 5-day Dry Immersion. We analyzed evoked responses to transcranial and trans-spinal magnetic stimulation. In this method, areas of interest (the motor cortex and lumbosacral thickening of the spinal cord) are stimulated with an electromagnetic stimulus. The experiment was conducted with the participation of 16 healthy female volunteers with a natural menstrual cycle. The thresholds, amplitudes, and latencies of motor potentials evoked by magnetic stimulation were assessed. We showed that 5-day exposure to support withdrawal leads to a decrease in motor-evoked potential thresholds and central motor conduction time, although changes in motor response amplitudes were ambiguous. The data obtained correspond to the results of previous research on Dry Immersion effects on the sensorimotor system in men.

A computational model of altered neuronal activity in altered gravity

“…Similarly, the effect of hypergravity can be studied using centrifuges [24,36] or an aircraft performing high-bank turns [37,38]. Alternative space analog studies for human subjects have been employed for decades such as bed rest [39][40][41] and dry immersion [42,43], and have also been used to study the effect of altered gravity on gene expression [44] and corticospinal excitability [45]. These studies feature traits such as physiological deconditioning but can not simulate the differential influence of gravity.…”