Corticomuscular coherence in acute and chronic stroke

Carlowitz-Ghori, Katherina von; Bayraktaroğlu, Zübeyir; Hohlefeld, Friederike U.; Losch, Florian; Curio, Gabriel; Nikulin, V

doi:10.1055/s-0034-1371233

Cited by 18 publications

(25 citation statements)

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“…An additional inhibitory pathway leading from the contralesional to the ipsilesional M1 has also been found in another study in stroke patients, and correlated with worse motor function (Grefkes et al, 2008). Connectivity increases between the ipsilesional M1 and contralesional M1 have been noted in many studies (De Vico Fallani et al, 2016;Li et al, 2014;Liu et al, 2016;Zhang et al, 2016) and were interpreted as a proof for the contralateral disinhibition theory (Volz et al, 2015;von Carlowitz-Ghori et al, 2014).…”

Section: The Role Of Increased Connectivitymentioning

confidence: 88%

Dynamics of brain connectivity after stroke

Desowska

Turner

2019

Reviews in the Neurosciences

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Recovery from a stroke is a dynamic time-dependent process, in which the central nervous system reorganises to accommodate for the impact of the injury. The purpose of this paper is to review recent longitudinal studies of changes in brain connectivity after stroke. A systematic review of research papers reporting functional or effective connectivity at two or more time points in stroke patients was conducted. Stroke leads to an early reduction of connectivity in the motor network. With recovery time, the connectivity increases and can reach the same levels as in healthy participants. The increase in connectivity is correlated with functional motor gains. A new, more randomised pattern of connectivity may then emerge in the longer term. In some instances, a pattern of increased connectivity even higher than in healthy controls can be observed, and is related either to a specific time point or to a specific neural structure. Rehabilitation interventions can help improve connectivity between specific regions. Moreover, motor network connectivity undergoes reorganisation during recovery from a stroke and can be related to behavioural recovery. A detailed analysis of changes in connectivity pattern may enable a better understanding of adaptation to a stroke and how compensatory mechanisms in the brain may be supported by rehabilitation.

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Section: The Role Of Increased Connectivitymentioning

confidence: 88%

Dynamics of brain connectivity after stroke

Desowska

Turner

2019

Reviews in the Neurosciences

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“…Although contributions from these indirect motor pathways are relatively smaller compared to corticospinal tract (indicated by bold red line) in able‐bodied individuals, these indirect pathways may become more dominant when the corticospinal tract is damaged after a stroke (Schwerin et al ., , ). Such a change can prolong the time delay from the cortex to periphery during movement control (Meng et al ., ) and modulate the value and frequency content of CMC (Yao & Dewald, ; von Carlowitz‐Ghori et al ., ). Nevertheless, considering the large interindividual differences in a healthy population, the absence of CMC and modulation of CMC may not necessarily indicate pathological control of movement.…”

Section: Corticomuscular Coherence: What We Know and What Did We Miss?mentioning

confidence: 97%

Unveiling neural coupling within the sensorimotor system: directionality and nonlinearity

Yang

Dewald

Helm

et al. 2017

Eur J of Neuroscience

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Neural coupling between the central nervous system and the periphery is essential for the neural control of movement. Corticomuscular coherence is a popular linear technique to assess synchronised oscillatory activity in the sensorimotor system. This oscillatory coupling originates from ascending somatosensory feedback and descending motor commands. However, corticomuscular coherence cannot separate this bidirectionality. Furthermore, the sensorimotor system is nonlinear, resulting in cross-frequency coupling. Cross-frequency oscillations cannot be assessed nor exploited by linear measures. Here, we emphasise the need of novel coupling measures, which provide directionality and acknowledge nonlinearity, to unveil neural coupling in the sensorimotor system. We highlight recent advances in the field and argue that assessing directionality and nonlinearity of neural coupling will break new ground in the study of the control of movement in healthy and neurologically impaired individuals.

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“…; von Carlowitz‐Ghori et al . ). Beta frequency coherence and motor unit synchronization is present between pairs of single motor units recorded from within the same muscle or from motor units recorded during co‐contraction of synergistic muscle pairs and is also impaired or altered by CNS lesions (Datta & Stephens, ; Datta et al .…”

Section: Introductionmentioning

confidence: 97%

A critical period of corticomuscular and EMG–EMG coherence detection in healthy infants aged 9–25 weeks

Ritterband-Rosenbaum

Herskind

et al. 2017

The Journal of Physiology

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The early postnatal development of functional corticospinal connections in human infants is not fully clarified. We used EEG and EMG to investigate the development of corticomuscular and intramuscular coherence as indicators of functional corticospinal connectivity in healthy infants aged 1-66 weeks. EEG was recorded over leg and hand area of motor cortex. EMG recordings were made from right ankle dorsiflexor and right wrist extensor muscles. Quantification of the amount of corticomuscular coherence in the 20-40 Hz frequency band showed a significantly larger coherence for infants aged 9-25 weeks compared to younger and older infants. Coherence between paired EMG recordings from tibialis anterior muscle in the 20-40 Hz frequency band was also significantly larger for the 9-25 week age group. A low-amplitude, broad-duration (40-50 ms) central peak of EMG-EMG synchronization was observed for infants younger than 9 weeks, whereas a short-lasting (10-20 ms) central peak was observed for EMG-EMG synchronization in older infants. This peak was largest for infants aged 9-25 weeks. These data suggest that the corticospinal drive to lower and upper limb muscles shows significant developmental changes with an increase in functional coupling in infants aged 9-25 weeks, a period which coincides partly with the developmental period of normal fidgety movements. We propose that these neurophysiological findings may reflect the existence of a sensitive period where the functional connections between corticospinal tract fibres and spinal motoneurones undergo activity-dependent reorganization. This may be relevant for the timing of early therapy interventions in infants with pre- and perinatal brain injury.

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Corticomuscular coherence in acute and chronic stroke

Cited by 18 publications

References 0 publications

Dynamics of brain connectivity after stroke

Dynamics of brain connectivity after stroke

Unveiling neural coupling within the sensorimotor system: directionality and nonlinearity

A critical period of corticomuscular and EMG–EMG coherence detection in healthy infants aged 9–25 weeks

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