Corticolimbic gray matter loss in Parkinson’s disease without dementia

Nishio, Yoshiyuki; Hirayama, Kazumi; Takeda, Atsushi; Hosokai, Yoshiyuki; Ishioka, Toshiyuki; Suzuki, Kyoko; Itoyama, Yasuto; Takahashi, Satoshi; Mori, Etsuro

doi:10.1111/j.1468-1331.2010.02980.x

Cited by 61 publications

(60 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some of these investigations reported distributed GM reduction in the patients with PD. [34][35][36] A few studies found more local reduction of GM in PD, although the regions were inconsistent across the studies. 37,38 In addition, some reports showed no differences between PD and controls.…”

Section: Resultsmentioning

confidence: 99%

Gray matter atrophy distinguishes between Parkinson disease motor subtypes

Rosenberg‐Katz

Herman²,

Jacob³

et al. 2013

Neurology

144

110

View full text Add to dashboard Cite

Objective: To assess differences in gray matter (GM) atrophy between 2 Parkinson disease (PD) subtypes: the tremor dominant (TD) subtype and the postural instability gait difficulty (PIGD) subtype.Methods: Patients were classified as belonging to the predominately PIGD (n 5 30) or predominately TD (n 5 29) subtype. Voxel-based morphometry was used to compare GM in these 2 subtypes and to evaluate correlations between predefined regions of interest and the degree of symptoms. In the regions where GM atrophy was associated with symptoms, the relationship between GM volumes and functional connectivity was examined.Results: GM was reduced in the predominately PIGD group, compared with the predominately TD group, in areas that involve motor, cognitive, limbic, and associative functions (p , 0.05, false discovery rate corrected). Lower GM volumes in the pre-supplementary motor area (SMA) and in the primary motor area were associated with increased severity of PIGD symptoms (r 5 20.42, p , 0.001; r 5 20.38, p , 0.003, respectively). Higher GM volumes within the pre-SMA were associated with stronger functional connectivity between the pre-SMA and the putamen (r 5 0.415, p , 0.025) in the patients with predominately PIGD. Conclusions:In patients with PD, PIGD symptoms are apparently associated with GM atrophy in motor-related regions and decreased functional connectivity. GM degeneration and a related decrease in spontaneous coactivation between cortical and subcortical motor-planning areas may partially account for the unique clinical characteristics of a subset of patients with PD.

show abstract

Section: Resultsmentioning

confidence: 99%

Gray matter atrophy distinguishes between Parkinson disease motor subtypes

Rosenberg‐Katz

Herman²,

Jacob³

et al. 2013

Neurology

144

110

View full text Add to dashboard Cite

show abstract

“…While some studies have identified extensive gray matter volume loss in temporoparietal and prefrontal areas in PD-MCI compared with controls, 28 others detected small density reductions in the precuneus, primary motor, parietal cortex, 29 in addition to occipital areas, 30 or cortical thinning in focal frontal regions. 31 However, the small sample sizes, lack of consistent criteria for defining MCI, and the use of different measures of atrophy are among the parameters that could account for inconsistent findings among previous studies.…”

Section: Vertex-wise Comparisons Of Cortical Thickness Between (A) Comentioning

confidence: 99%

Initial cognitive decline is associated with cortical thinning in early Parkinson disease

et al. 2014

View full text Add to dashboard Cite

Objectives: Our aim was to assess cortical thickness in a large multicenter cohort of drug-naive patients with early Parkinson disease (PD), with and without mild cognitive impairment (MCI), and explore the cognitive correlates of regional cortical thinning.Methods: One hundred twenty-three newly diagnosed patients with PD and 56 healthy controls with 3-tesla structural MRI scans and complete neuropsychological assessment from the Parkinson's Progression Markers Initiative were included. Modified Movement Disorders Society Task Force level II criteria were applied to diagnose MCI in PD. FreeSurfer image processing and analysis software was used to measure cortical thickness across groups and the association with cognitive domains and tests.Results: In patients with MCI, atrophy was found in temporal, parietal, frontal, and occipital areas compared with controls. Specific regional thinning in the right inferior temporal cortex was also found in cognitively normal patients. Memory, executive, and visuospatial performance was associated with temporoparietal and superior frontal thinning, suggesting a relationship between cognitive impairment and both anterior and posterior cortical atrophy in the whole patient sample.Conclusions: These findings confirm that MCI is associated with widespread cortical atrophy. In addition, they suggest that regional cortical thinning is already present at the time of diagnosis in patients with early, untreated PD who do not meet the criteria for MCI. Together, the results indicate that cortical thinning can serve as a marker for initial cognitive decline in early PD.

show abstract

“…Investigations employing structural MRI analysed by visual inspection, region of interest and whole brain voxel based morphometry (VBM) methods have reported grey matter atrophy associated with dementia in PD in the basal ganglia, medial temporal and limbic areas, as well as other cortical regions 4–8. Some studies defining a single ‘non-dementia’ group of PD subjects have reported atrophy in the medial temporal lobe,4 7–10 amygdala,7 frontal regions6 10 and cerebellum 11. In contradistinction, others have found no significant atrophy in PD without dementia 12–15.…”

Section: Introductionmentioning

confidence: 99%

“…However, small sample size and lack of consistent criteria for defining cognitive impairment complicate the interpretation of these structural imaging results and perhaps explain inconsistent findings. Some studies have identified grey matter atrophy in PD-MCI patients in the temporal lobe (including the hippocampus and parahippocampus), frontal regions and cerebellum, relative to healthy individuals or PD patients without cognitive impairment 10 19 20. In contrast, other studies have reported either no or unreliable grey matter changes in PD-MCI compared with controls or PD-N 5 21 22.…”

Section: Introductionmentioning

confidence: 99%