Cortico‐cortical connectivity within ferret auditory cortex

Bizley, Jennifer K.; Bajo, Victoria M.; Nodal, Fernando R.; King, Andrew J.

doi:10.1002/cne.23784

Cited by 27 publications

(36 citation statements)

References 73 publications

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“…At lateral distances further than 500 μm from the outside of the loop the temperature in cortex did not fall below 20°C (the level which is required for cessation of neural firing [5]); thus cooling was contained to within A1 (Fig 2B). Auditory cortex in ferrets is typically ~1500 μm thick reaching a maximum of 2000 μm only at the thickest part of the gyrus [28]. At 1500 μm in depth cortical temperature measurements from the centre of the loop were <20°C and remained so until ~1750 μm indicating that it was likely that all layers of the cortex were cooled in the centre of the loop.…”

Section: Resultsmentioning

confidence: 99%

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Acute Inactivation of Primary Auditory Cortex Causes a Sound Localisation Deficit in Ferrets

et al. 2017

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The objective of this study was to demonstrate the efficacy of acute inactivation of brain areas by cooling in the behaving ferret and to demonstrate that cooling auditory cortex produced a localisation deficit that was specific to auditory stimuli. The effect of cooling on neural activity was measured in anesthetized ferret cortex. The behavioural effect of cooling was determined in a benchmark sound localisation task in which inactivation of primary auditory cortex (A1) is known to impair performance. Cooling strongly suppressed the spontaneous and stimulus-evoked firing rates of cortical neurons when the cooling loop was held at temperatures below 10°C, and this suppression was reversed when the cortical temperature recovered. Cooling of ferret auditory cortex during behavioural testing impaired sound localisation performance, with unilateral cooling producing selective deficits in the hemifield contralateral to cooling, and bilateral cooling producing deficits on both sides of space. The deficit in sound localisation induced by inactivation of A1 was not caused by motivational or locomotor changes since inactivation of A1 did not affect localisation of visual stimuli in the same context.

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Section: Resultsmentioning

confidence: 99%

“…The dashed line shows the temperature below which neural firing ceases [5]. Ferret auditory cortex is usually ~1500 μm thick and extends to a maximum of 2000 μm at the thickest part of the gyrus [28]. …”

Section: Methodsmentioning

confidence: 99%

Acute Inactivation of Primary Auditory Cortex Causes a Sound Localisation Deficit in Ferrets

et al. 2017

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“…For example, recent research has made considerable headway in mapping distinct anatomical and functional regions of the ferret brain. In particular, the function of the ferret visual and auditory cortices has been well characterized (Basole et al, 2003; Li et al, 2008; Bizley and King, 2009; Bizley et al, 2015; Smith et al, 2015; Town et al, 2015; Roy et al, 2016). There is substantial evidence for the sophistication of the ferret visual system through development.…”

Section: Discussionmentioning

confidence: 99%

“…A map of neurotypical functional connectivity patterns would serve as a framework for translational studies in the ferret. Despite studies exploring the structure and function of individual brain regions, such large-scale brain network topology in the ferret has yet to be examined (Manger et al, 2002; Basole et al, 2003; Bizley and King, 2009; Fritz et al, 2010; Sellers et al, 2013; Bizley et al, 2015; Yu et al, 2015; Zhou et al, 2016b). …”

Section: Introductionmentioning

confidence: 99%

Resting state network topology of the ferret brain

et al. 2016

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Resting state functional magnetic resonance imaging (rsfMRI) has emerged as a versatile tool for non-invasive measurement of functional connectivity patterns in the brain. RsfMRI brain dynamics in rodents, non-human primates, and humans share similar properties; however, little is known about the resting state functional connectivity patterns in the ferret, an animal model with high potential for developmental and cognitive translational study. To address this knowledge-gap, we performed rsfMRI on anesthetized ferrets using a 9.4 tesla MRI scanner, and subsequently performed group-level independent component analysis (gICA) to identify functionally connected brain networks. Group-level ICA analysis revealed distributed sensory, motor, and higher-order networks in the ferret brain. Subsequent connectivity analysis showed interconnected higher-order networks that constituted a putative default mode network (DMN), a network that exhibits altered connectivity in neuropsychiatric disorders. Finally, we assessed ferret brain topological efficiency using graph theory analysis and found that the ferret brain exhibits small-world properties. Overall, these results provide additional evidence for pan-species resting-state networks, further supporting ferret-based studies of sensory and cognitive function.

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“…To date, the gold standard for assessing structural brain connectivity is provided by tract-tracing experiments, which physically investigate, at the cellular level, the relative number of connections of an area to the rest of the brain using viral, bacterial or biotinylated dextran agents (Bizley, Bajo, Nodal, & King, 2015;Bota, Sporns, & Swanson, 2015;Markov et al, 2014;Zingg et al, 2015) . These agents act as either anterograde or retrograde tracers.…”

Section: Introductionmentioning

confidence: 99%

Comparison between diffusion MRI tractography and histological tract-tracing of cortico-cortical structural connectivity in the ferret brain

Delettre

Messé

Dell

et al. 2019

Preprint

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The anatomical wiring of the brain is a central focus in network neuroscience. Diffusion MRI tractography offers the unique opportunity to investigate the brain fiber architecture in vivo and non invasively. However, its reliability is still highly debated. Here, we explored the ability of diffusion MRI tractography to match invasive anatomical tract-tracing connectivity data of the ferret brain. We also investigated the influence of several state-of-the-art tractography algorithms on this match to ground truth connectivity data. Tract-tracing connectivity data were obtained from retrograde tracer injections into the occipital, parietal and temporal cortices of adult ferrets. We found that the relative densities of projections identified from the anatomical experiments were highly correlated with the estimates from all the studied diffusion tractography algorithms (Spearman's rho ranging from 0.67 to 0.91), while only small, non-significant variations appeared across the tractography algorithms. These results are comparable to findings reported in mouse and monkey, increasing the confidence in diffusion MRI tractography results. Moreover, our results provide insights into the variations of sensitivity and specificity of the tractography algorithms and hence, into the influence of choosing one algorithm over another.

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Cortico‐cortical connectivity within ferret auditory cortex

Cited by 27 publications

References 73 publications

Acute Inactivation of Primary Auditory Cortex Causes a Sound Localisation Deficit in Ferrets

Acute Inactivation of Primary Auditory Cortex Causes a Sound Localisation Deficit in Ferrets

Resting state network topology of the ferret brain

Comparison between diffusion MRI tractography and histological tract-tracing of cortico-cortical structural connectivity in the ferret brain

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