Cortical thickness, stance control, and arithmetic skill: An exploratory study in premanifest Huntington disease

Nanetti, Lorenzo; Contarino, Valeria Elisa; Castaldo, Anna; Sarro, Lidia; Bachoud-Lévi, A C; Giavazzi, Maria; Frittoli, S.; Ciammola, Andrea; Rizzo, Elena; Gellera, Cinzia; Bruzzone, Maria Grazia; Taroni, Franco; Grisoli, Marina; Mariotti, Caterina

doi:10.1016/j.parkreldis.2018.02.033

Cited by 22 publications

(20 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We confirmed previous studies investigating neurodegeneration in close-to-onset pre-HD [32]. The pattern of morphological alterations in close-to-onset pre-HD is congruent with recent data from a metaanalysis reporting volume reduction in the bilateral striatum and right middle occipital gyrus in pre-HD ( Fig.…”

Section: Discussionsupporting

confidence: 92%

Striatal connectivity in pre‐manifest Huntington’s disease is differentially affected by disease burden

Pini

Youssov

Sambataro

et al. 2020

Euro J of Neurology

View full text Add to dashboard Cite

Background and purpose: Different amounts of cumulative exposure to the toxic mutant form of the huntingtin protein might underlie the distinctive pattern of striatal connectivity in pre-manifest Huntington's disease (pre-HD). The aim of this study was to investigate disease-burden-dependent corticalstriatal and subcortical-striatal loops at different pre-HD stages. Methods: A total of 16 participants with pre-HD and 25 controls underwent magnetic resonance imaging to investigate striatal structural and functional connectivity (FC). Individuals with pre-HD were stratified into far-from-onset and close-to-onset disease groups according to the disease-burden score. Cortical-striatal and subcortical-striatal FC was investigated through seed-region of interest (ROI) and ROI-to-ROI approaches, respectively. The integrity of white-matter pathways originating from striatal seeds was investigated through probabilistic tractography. Results: In far-from-onset pre-HD, the left caudate nucleus showed cortical increased FC in brain regions overlapping with the default mode network and increased coupling connectivity with the bilateral thalamus. By contrast, close-to-onset individuals showed increased fractional anisotropy (and mean diffusivity) in the right caudate nucleus and widespread striatal atrophy. Finally, we reported an association between cortical-caudate FC and caudate structural connectivity, although this did not survive multiple comparison correction. Conclusions: Functional reorganization of the caudate nucleus might underlie plasticity compensatory mechanisms that recede as individuals with pre-HD approach clinical symptom onset and neurodegeneration.

show abstract

Section: Discussionsupporting

confidence: 92%

Striatal connectivity in pre‐manifest Huntington’s disease is differentially affected by disease burden

Pini

Youssov

Sambataro

et al. 2020

Euro J of Neurology

View full text Add to dashboard Cite

show abstract

“…Numeracy tests were purposefully selected to evaluate cognitive performance given their proven sensitivity in individuals with HD and ecological validity (use in everyday life, particularly the management of finances and time). 24…”

Section: Cognitive Tasksmentioning

confidence: 99%

Dual tasking impairments are associated with striatal pathology in Huntington’s disease

Reyes

Pulverenti

et al. 2020

Ann Clin Transl Neurol

View full text Add to dashboard Cite

Background Recent findings suggest that individuals with Huntington’s disease (HD) have an impaired capacity to execute cognitive and motor tasks simultaneously, or dual task, which gradually worsens as the disease advances. The onset and neuropathological changes mediating impairments in dual tasking in individuals with HD are unclear. The reliability of dual tasking assessments for individuals with HD is also unclear. Objectives To evaluate differences in dual tasking performance between individuals with HD (presymptomatic and prodromal) and matched controls, to investigate associations between striatal volume and dual tasking performance, and to determine the reliability of dual tasking assessments. Methods Twenty individuals with HD (10 presymptomatic and 10 prodromal) and 20 healthy controls were recruited for the study. Individuals undertook four single and dual task assessments, comprising motor (postural stability or force steadiness) and cognitive (simple or complex mental arithmetic) components, with single and dual tasks performed three times each. Participants also undertook a magnetic resonance imaging assessment. Results Compared to healthy controls, individuals with presymptomatic and prodromal HD displayed significant deficits in dual tasking, particularly cognitive task performance when concurrently undertaking motor tasks (P < 0.05). The observed deficits in dual tasking were associated with reduced volume in caudate and putamen structures (P < 0.05),however, not with clinical measures of disease burden. An analysis of the reliability of dual tasking assessments revealed moderate to high test–retest reliability [ICC: 0.61‐0.99] for individuals with presymptomatic and prodromal HD and healthy controls. Conclusions Individuals with presymptomatic and prodromal HD have significant deficits in dual tasking that are associated with striatal degeneration. Findings also indicate that dual tasking assessments are reliable in individuals presymptomatic and prodromal HD and healthy controls.

show abstract

“…The neuroanatomical hallmark of HD includes early loss of GABAergic inhibitory neurons and atrophy of the striatum (Vonsattel et al, ). As pathology proceeds, neuronal degeneration spreads to the cortex and other extrastriatal regions (Nanetti et al, ; Rosas et al, ). However, the relationship between brain atrophy and clinical symptoms is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Aberrant brain network connectivity in presymptomatic and manifest Huntington's disease: A systematic review

Pini

Jacquemot

Cagnin

et al. 2019

Human Brain Mapping

View full text Add to dashboard Cite

Resting‐state functional magnetic resonance imaging (rs‐fMRI) has the potential to shed light on the pathophysiological mechanisms of Huntington's disease (HD), paving the way to new therapeutic interventions. A systematic literature review was conducted in three online databases according to PRISMA guidelines, using keywords for HD, functional connectivity, and rs‐fMRI. We included studies investigating connectivity in presymptomatic (pre‐HD) and manifest HD gene carriers compared to healthy controls, implementing seed‐based connectivity, independent component analysis, regional property, and graph analysis approaches. Visual network showed reduced connectivity in manifest HD, while network/areas underpinning motor functions were consistently altered in both manifest HD and pre‐HD, showing disease stage‐dependent changes. Cognitive networks underlying executive and attentional functions showed divergent anterior–posterior alterations, possibly reflecting compensatory mechanisms. The involvement of these networks in pre‐HD is still unclear. In conclusion, aberrant connectivity of the sensory‐motor network is observed in the early stage of HD while, as pathology spreads, other networks might be affected, such as the visual and executive/attentional networks. Moreover, sensory‐motor and executive networks exhibit hyper‐ and hypo‐connectivity patterns following different spatiotemporal trajectories. These findings could potentially help to implement future huntingtin‐lowering interventions.

show abstract

Cortical thickness, stance control, and arithmetic skill: An exploratory study in premanifest Huntington disease

Cited by 22 publications

References 26 publications

Striatal connectivity in pre‐manifest Huntington’s disease is differentially affected by disease burden

Striatal connectivity in pre‐manifest Huntington’s disease is differentially affected by disease burden

Dual tasking impairments are associated with striatal pathology in Huntington’s disease

Aberrant brain network connectivity in presymptomatic and manifest Huntington's disease: A systematic review

Contact Info

Product

Resources

About