Cortical thickness reductions associate with abnormal resting-state functional connectivity in non-neuropsychiatric systemic lupus erythematosus

Niu, Chen; Tan, Xiangliang; Liu, Xiaojin; Han, Kai; Niu, Meiqi; Xu, Jun; Zhao, Ling; Wu, Yuankui; Deng, Feng; Huang, Qin; Wu, Xiaoyan; Huang, Huiyuan; Xu, Yikai; Huang, Ruiwang

doi:10.1007/s11682-017-9729-4

Cited by 22 publications

(12 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CBF significantly increased in GM in the temporal gyrus, cingulate gyrus, and cerebellum regions and in widespread WM in non‐NPSLE patients compared with NCs. We hypothesized that this result may be caused by a compensatory mechanism in response to ischemia or injury, which was consistent with previous fMRI studies showing hyperactivities and hyperconnectivity within certain specific networks (e.g., the sensorimotor network) (Mikdashi, ; Niu et al, ; Nystedt et al, ; Papadaki et al, ; Wu et al, ; Zhang et al, ). However, in NPSLE patients, along with widespread vasculopathy and thrombosis, the perfusion of these brain regions was significantly decreased, which means a large reduction in compensatory capacity when the damage exceeded the threshold.…”

Section: Discussionsupporting

confidence: 86%

Different patterns of cerebral perfusion in SLE patients with and without neuropsychiatric manifestations

Zhuo

Duan

et al. 2019

Human Brain Mapping

View full text Add to dashboard Cite

To investigate brain perfusion patterns in systemic lupus erythematosus (SLE) patients with and without neuropsychiatric systemic lupus erythematosus (NPSLE and non-NPSLE, respectively) and to identify biomarkers for the diagnosis of NPSLE using noninvasive three-dimensional (3D) arterial spin labeling (ASL). Thirty-one NPSLE and 24 non-NPSLE patients and 32 age-and sex-matched normal controls (NCs) were recruited. Three-dimensional ASL-MRI was applied to quantify cerebral perfusion. Whole brain, gray (GM) and white matter (WM), and voxel-based analysis (VBA) were performed to explore perfusion characteristics. Correlation analysis was performed to find the relationship between the perfusion measures, lesion volumes, and clinical variables. Receiver operating characteristic (ROC) analysis and support vector machine (SVM) classification were applied to differentiate NPSLE patients from non-NPSLE patients and healthy controls. Compared to NCs, NPSLE patients showed increased cerebral blood flow (CBF) within WM but decreased CBF within GM, while non-NPSLE patients showed increased CBF within both GM and WM. Compared to non-NPSLE patients, NPSLE patients showed significantly reduced CBF in the frontal gyrus, cerebellum, and corpus callosum. CBF within several brain regions such as cingulate and corpus callosum showed significant correlations with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and the Systemic Lupus International Collaborating Clinics (SLICC) damage index scores. ROC analysis showed moderate performance in distinguishing NPSLE from non-NPSLE patients with AUCs > 0.7, while SVM analysis demonstrated that CBF within the corpus callosum achieved an accuracy of 83.6% in distinguishing NPSLE from non-NPSLE patients. Different brain perfusion patterns were observed between NPSLE and non-NPSLE patients. CBF measured by noninvasive 3D ASL could be a useful biomarker for the diagnosis and disease monitoring of NPSLE and non-NPSLE patients. K E Y W O R D S 3D arterial spin labeling, neuropsychiatric systemic lupus erythematosus, perfusion, systemic lupus erythematosus Zhizheng Zhuo and Li Su contributed equally to this study.

show abstract

Section: Discussionsupporting

confidence: 86%

Different patterns of cerebral perfusion in SLE patients with and without neuropsychiatric manifestations

Zhuo

Duan

et al. 2019

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…Blood oxygen level–dependent functional MRI (BOLD fMRI) measures local brain deoxyhemoglobin levels, an indirect measure of brain function within gray matter . BOLD fMRI data are acquired either in task/stimulus‐based paradigms (providing statistical parametric maps linked to a specific function), or in resting‐state acquisitions (providing functional connectivity maps of brain networks such as the default mode).…”

Section: Current Status Of Npslementioning

confidence: 99%

“…These compensatory responses maintain cognitive function in the short term but may eventually be overcome and manifest as overt cognitive impairment . Even SLE patients without clinical NP disease have abnormal fMRI resting‐state brain intrinsic connectivity , raising the possibility of preclinical detection .…”

Section: Current Status Of Npslementioning

confidence: 99%

Nervous System Disease in Systemic Lupus Erythematosus: Current Status and Future Directions

Hanly

Kozora

Beyea

et al. 2018

Arthritis & Rheumatology

119

103

View full text Add to dashboard Cite

The American College of Rheumatology's case definitions for 19 neuropsychiatric syndromes in systemic lupus erythematosus (SLE) constitute a comprehensive classification of nervous system events in this disease. However, additional strategies are needed to determine whether a neuropsychiatric syndrome is attributable to SLE versus a competing comorbidity. Cognitive function is a clinical surrogate of overall brain health, with applications in both diagnosis and determination of clinical outcomes. Ischemic and inflammatory mechanisms are both key components of the immunopathogenesis of neuropsychiatric SLE (NPSLE), including abnormalities of the blood-brain barrier and autoantibody-mediated production of proinflammatory cytokines. Advances in neuroimaging provide a platform to assess novel disease mechanisms in a noninvasive way. The convergence of more rigorous clinical characterization, validation of biomarkers, and brain neuroimaging provides opportunities to determine the efficacy of novel targeted therapies in the treatment of NPSLE.

show abstract

“…Recently, RS-fMRI researches indicated reduced connectivity within the default mode network (DMN), the central executive network (CEN), and in-between the DMN and CEN in SLE [12]. Abnormal cortical thickness in the left lingual gyrus was found to be associated with increased resting-state functional connectivity of the left posterior cingulate cortex in non-NPSLE patients [13]. By both RS-fMRI and task-based fMRI, the abnormal functional connectivity of frontal-parietal was found to be associated with diseased activity in SLE patients [14].…”

Section: Introductionmentioning

confidence: 99%

Altered Amplitude of Low-Frequency Fluctuations in Inactive Patients with Nonneuropsychiatric Systemic Lupus Erythematosus

Chen

Wang

et al. 2019

Neural Plasticity

View full text Add to dashboard Cite

ObjectiveThis study is aimed at investigating the characteristics of the spontaneous brain activity in inactive patients with nonneuropsychiatric systemic lupus erythematosus (non-NPSLE). Methods Thirty-one female inactive patients with non-NPSLE and twenty healthy controls were examined by resting-state functional magnetic resonance imaging (RS-fMRI). Three amplitude methods including amplitude of low-frequency fluctuations (ALFF), fractional amplitude of low-frequency fluctuations (fALFF), and percent amplitude of fluctuation (PerAF) (with and without standardization) were applied to evaluate the spontaneous brain activity. The correlation was performed between low-frequency oscillations and clinical and neuropsychological factors in inactive patients with non-NPSLE. Results Compared to healthy controls, patients with non-NPSLE showed increased standardized ALFF (mALFF) in the left inferior temporal gyrus and left putamen, decreased PerAF in the right postcentral gyrus and bilateral precentral gyrus, and increased standardized PerAF (mPerAF) in the left putamen and decreased mPerAF in the right postcentral gyrus and bilateral precentral gyrus. By standardized fALFF (mfALFF), no significant brain regions were found between the two groups. Correlation analysis revealed significantly positive correlations between glucocorticoid dose and PerAF in the right precentral gyrus and mPerAF in the left putamen, and Complement 3 (C3) and mPerAF in the right postcentral gyrus. There was a significant negative correlation between C3 and mALFF in the left putamen. Conclusion Abnormal low-frequency oscillations in multiple brain regions were found in inactive patients with non-NPSLE, indicating that the alteration of mALFF, PerAF, and mPerAF in specific brain regions might be an imaging biomarker of brain dysfunction in inactive patients with non-NPSLE.

show abstract

Cortical thickness reductions associate with abnormal resting-state functional connectivity in non-neuropsychiatric systemic lupus erythematosus

Cited by 22 publications

References 47 publications

Different patterns of cerebral perfusion in SLE patients with and without neuropsychiatric manifestations

Different patterns of cerebral perfusion in SLE patients with and without neuropsychiatric manifestations

Nervous System Disease in Systemic Lupus Erythematosus: Current Status and Future Directions

Altered Amplitude of Low-Frequency Fluctuations in Inactive Patients with Nonneuropsychiatric Systemic Lupus Erythematosus

Contact Info

Product

Resources

About