Cortical thickness of the frontopolar area in typically developing children and adolescents

O’Donnell, Shannon; Noseworthy, Michael D.; Levine, Brian; Dennis, Maureen

doi:10.1016/j.neuroimage.2004.10.014

Cited by 120 publications

(78 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Freesurfer morphometry has demonstrated good test-retest reliability across scanner manufacturers and field strengths (Han et al, 2006;Reuter et al, 2012). Numerous studies using Freesurfer in typical and atypical developing schoolaged children are available (O'Donnell et al, 2005;Derauf et al, 2009;Ghosh et al, 2010;Ducharme et al, 2012). All Freesurfer output was visually inspected for quality control.…”

Section: Cortical and Volumetric Measures And Cortical Thicknessmentioning

confidence: 99%

Prenatal Tobacco Exposure and Brain Morphology: A Prospective Study in Young Children

Marroun

Schmidt

Franken

et al. 2013

Neuropsychopharmacol

103

View full text Add to dashboard Cite

It is well known that smoking during pregnancy can affect offspring health. Prenatal tobacco exposure has been associated with negative behavioral and cognitive outcomes in childhood, adolescence, and young adulthood. These associations between prenatal tobacco exposure and psychopathology in offspring could possibly be explained by the influence of prenatal tobacco exposure on brain development. In this prospective study, we investigated the association between prenatal tobacco exposure, behavioral and emotional functioning and brain morphology in young children. On the basis of age and gender, we matched 113 children prenatally exposed to tobacco with 113 unexposed controls. These children were part of a population-based study in the Netherlands, the Generation R Study, and were followed from pregnancy onward. Behavioral and emotional functioning was assessed at age 6 with the Child Behavior Checklist. We assessed brain morphology using magnetic resonance imaging techniques in children aged 6-8 years. Children exposed to tobacco throughout pregnancy have smaller total brain volumes and smaller cortical gray matter volumes. Continued prenatal tobacco exposure was associated with cortical thinning, primarily in the superior frontal, superior parietal, and precentral cortices. These children also demonstrated increased scores of affective problems. In addition, thickness of the precentral and superior frontal cortices was associated with affective problems. Importantly, brain development in offspring of mothers who quit smoking during pregnancy resembled that of nonexposed controls (no smaller brain volumes and no thinning of the cortex). Our findings suggest an association between continued prenatal tobacco exposure and brain structure and function in school-aged children.

show abstract

Section: Cortical and Volumetric Measures And Cortical Thicknessmentioning

confidence: 99%

Prenatal Tobacco Exposure and Brain Morphology: A Prospective Study in Young Children

Marroun

Schmidt

Franken

et al. 2013

Neuropsychopharmacol

103

View full text Add to dashboard Cite

show abstract

“…Cortical thickness was chosen as a metric which both captures the columnar architecture of the cortex and is sensitive to developmental change in typically developing and clinical populations O'Donnell et al, 2005;Makris et al, 2006;Shaw et al, 2006a,b;Lu et al, 2007;Sowell et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Neurodevelopmental Trajectories of the Human Cerebral Cortex

Shaw¹,

Kabani²,

Lerch³

et al. 2008

View full text Add to dashboard Cite

Understanding the organization of the cerebral cortex remains a central focus of neuroscience. Cortical maps have relied almost exclusively on the examination of postmortem tissue to construct structural, architectonic maps. These maps have invariably distinguished between areas with fewer discernable layers, which have a less complex overall pattern of lamination and lack an internal granular layer, and those with more complex laminar architecture. The former includes several agranular limbic areas, and the latter includes the homotypical and granular areas of association and sensory cortex. Here, we relate these traditional maps to developmental data from noninvasive neuroimaging. Changes in cortical thickness were determined in vivo from 764 neuroanatomic magnetic resonance images acquired longitudinally from 375 typically developing children and young adults. We find differing levels of complexity of cortical growth across the cerebrum, which align closely with established architectonic maps. Cortical regions with simple laminar architecture, including most limbic areas, predominantly show simpler growth trajectories. These areas have clearly identified homologues in all mammalian brains and thus likely evolved in early mammals. In contrast, polysensory and high-order association areas of cortex, the most complex areas in terms of their laminar architecture, also have the most complex developmental trajectories. Some of these areas are unique to, or dramatically expanded in primates, lending an evolutionary significance to the findings. Furthermore, by mapping a key characteristic of these development trajectories (the age of attaining peak cortical thickness) we document the dynamic, heterochronous maturation of the cerebral cortex through time lapse sequences ("movies").

show abstract

“…The pubertal period partly overlaps with adolescence, but is usually referred to as the period during which behavioral, cognitive, and emotional changes arise as well [Sisk and Zehr, 2005]. During the course of childhood and adolescence, prominent brain changes take place in the proportion of gray and white matter within the cerebrum: region-specific gray matter decreases have been reported Gogtay et al, 2004;Jernigan et al, 1991;O'Donnell et al, 2005;Sowell et al, 2002Sowell et al, , 2004Thompson et al, 2000;Wilke et al, 2007], as well as white matter increases [Barnea-Goraly et al, 2005;Giedd et al, 1999;Paus et al, 1999;Thompson et al, 2000]. Especially, around the onset of puberty, global gray matter as well as frontal and parietal gray matter Jernigan et al, 1991] start to decrease.…”

Section: Introductionmentioning

confidence: 99%

Heritability of regional and global brain structure at the onset of puberty: A magnetic resonance imaging study in 9‐year‐old twin pairs

Peper

Schnack

Brouwer

et al. 2009

Human Brain Mapping

167

139

View full text Add to dashboard Cite

Puberty represents the phase of sexual maturity, signaling the change from childhood into adulthood. During childhood and adolescence, prominent changes take place in the brain. Recently, variation in frontal, temporal, and parietal areas was found to be under varying genetic control between 5 and 19 years of age. However, at the onset of puberty, the extent to which variation in brain structures is influenced by genetic factors (heritability) is not known. Moreover, whether a direct link between human pubertal development and brain structure exists has not been studied. Here, we studied the heritability of brain structures at 9 years of age in 107 monozygotic and dizygotic twin pairs (N 5 210 individuals) using volumetric MRI and voxel-based morphometry. Children showing the first signs of secondary sexual characteristics (N 5 47 individuals) were compared with children without these signs, based on Tanner-stages. High heritabilities of intracranial, total brain, cerebellum, and gray and white matter volumes (up to 91%) were found. Regionally, the posterior fronto-occipital, corpus callosum, and superior longitudinal fascicles (up to 93%), and the amygdala, superior frontal and middle temporal cortices (up to 83%) were significantly heritable. The onset of secondary sexual characteristics of puberty was associated with decreased frontal and parietal gray matter densities. Thus, in 9-year-old children, global brain volumes, white matter density in fronto-occipital and superior longitudinal fascicles, and gray matter density of (pre-)frontal and temporal areas are highly heritable. Pubertal development may be directly involved in the decreases in gray matter areas that accompany the transition of our brains from childhood into adulthood.

show abstract

Cortical thickness of the frontopolar area in typically developing children and adolescents

Cited by 120 publications

References 12 publications

Prenatal Tobacco Exposure and Brain Morphology: A Prospective Study in Young Children

Prenatal Tobacco Exposure and Brain Morphology: A Prospective Study in Young Children

Neurodevelopmental Trajectories of the Human Cerebral Cortex

Heritability of regional and global brain structure at the onset of puberty: A magnetic resonance imaging study in 9‐year‐old twin pairs

Contact Info

Product

Resources

About