Cortical thickness of supratemporal plane predicts auditory N1 amplitude

Liem, Franziskus; Zaehle, Tino; Burkhard, Anja; Jäncke, Lutz; Meyer, Martin

doi:10.1097/wnr.0b013e32835abc5c

Cited by 28 publications

(22 citation statements)

References 27 publications

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“…The primary source of N1 and P2 is the auditory cortex (35, 36) (Heschl's gyrus); we identified reduction in gray matter regions surrounding this structure. Parietal target N2 in E2 was significantly increased (reduced change from baseline) in probands indexing abnormal stimulus classification (37).…”

Section: Discussionmentioning

confidence: 87%

Genetic Sources of Subcomponents of Event-Related Potential in the Dimension of Psychosis Analyzed From the B-SNIP Study

Narayanan¹,

Ethridge²,

O’Neil³

et al. 2015

AJP

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Objective Biological risk factors underlying psychosis are poorly understood. Biological underpinnings of the dimension of psychosis can be derived using genetic associations with intermediate phenotypes such as sub-components of auditory event related potentials (ERPs). Various ERP sub-component abnormalities in schizophrenia (SZ) and bipolar disorder with psychosis (PBP) are heritable and expressed in unaffected relatives. Prior studies investigating genetic contributions to ERP abnormalities are limited. We used a novel parallel independent component analysis (Para-ICA) to determine which empirically-derived gene clusters are associated with data-driven ERP sub-components, assuming a complex etiology underlying psychosis. Methods We examined the multivariate polygenic association of ERP sub-components from 64-channel auditory oddball data in 144 SZ, 210 PBP probands and 95 healthy individuals from the multi-site BSNIP study. Data were reduced by principal component analysis to 2 target and 1 standard ERP waveforms. Multivariate association of compressed ERP waveforms with a set of 20,329 SNPs (reduced from a one million SNP array) was examined using Para-ICA. Genes associated with SNPs were further examined using pathway analysis tools. Results Para-ICA identified 4 ERP components that were significantly correlated with 3 genetic components. Enrichment analysis revealed complement immune response pathway and multiple processes including synaptic cell adhesion, axon guidance and neurogenesis significantly mediating ERP abnormalities in psychosis. Conclusions We identified three genetic components comprising multiple genes mediating ERP sub-component abnormalities in SZ and PBP. Our data suggest a possible polygenic structure comprised of genes influencing key neurodevelopmental processes, neural circuitry, brain function mediating biological pathways plausibly associated with psychoses.

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Section: Discussionmentioning

confidence: 87%

Genetic Sources of Subcomponents of Event-Related Potential in the Dimension of Psychosis Analyzed From the B-SNIP Study

Narayanan¹,

Ethridge²,

O’Neil³

et al. 2015

AJP

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“…Structural measures reflecting auditory experience and development, such as the cortical thickness of Heschl’s Gyrus in auditory cortex, have also been correlated with the N1 response (Fu and Zuo, 2011; Liem et al, 2012). As children age through pre-adolescence, region-dependent decreases in gray matter volume occur, concurrent with white matter volume increases, possibly providing a structural basis for developmental changes reported for the N1 CAEP (Gogtay et al, 2004; Group B.D.C., 2012; Lenroot and Giedd, 2006; Muftuler et al, 2011).…”

Section: Central Auditory Development In Deafnessmentioning

confidence: 99%

Developmental and cross-modal plasticity in deafness: Evidence from the P1 and N1 event related potentials in cochlear implanted children

Sharma

Campbell

Cardon

2015

International Journal of Psychophysiology

135

114

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Cortical development is dependent on extrinsic stimulation. As such, sensory deprivation, as in congenital deafness, can dramatically alter functional connectivity and growth in the auditory system. Cochlear implants ameliorate deprivation-induced delays in maturation by directly stimulating the central nervous system, and thereby restoring auditory input. The scenario in which hearing is lost due to deafness and then reestablished via a cochlear implant provides a window into the development of the central auditory system. Converging evidence from electrophysiologic and brain imaging studies of deaf animals and children fitted with cochlear implants has allowed us to elucidate the details of the time course for auditory cortical maturation under conditions of deprivation. Here, we review how the P1 cortical auditory evoked potential (CAEP) provides useful insight into sensitive period cut-offs for development of the primary auditory cortex in deaf children fitted with cochlear implants. Additionally, we present new data on similar sensitive period dynamics in higher-order auditory cortices, as measured by the N1 CAEP in cochlear implant recipients. Furthermore, cortical re-organization, secondary to sensory deprivation, may take the form of compensatory cross-modal plasticity. We provide new case-study evidence that cross-modal re-organization, in which intact sensory modalities (i.e., vision and somatosensation) recruit cortical regions associated with deficient sensory modalities (i.e., auditory) in cochlear implanted children may influence their behavioral outcomes with the implant. Improvements in our understanding of developmental neuroplasticity in the auditory system should lead to harnessing central auditory plasticity for superior clinical technique.

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“…Since the P1 response complex may include not only primary activation but also, to a minor proportion, early secondary pitch‐sensitive responses of lateral HG (Yvert et al, ; Schneider et al, ), it is important to separate the earlier primary component by appropriate constraints (Schneider et al, ; Wengenroth et al, ). In a combined MRI and EEG study, Liem, Zaehle, Burkhard, Jancke, and Meyer () have reported thinner CTH to be associated with larger N1 amplitude in lateral HG. Furthermore, it is well‐known that auditory response patterns differ between children and adults under influence of maturational learning processes.…”

Section: Introductionmentioning

confidence: 99%

Reduced cortical thickness in Heschl's gyrus as an in vivo marker for human primary auditory cortex

Zoellner

Benner

Zeidler

et al. 2018

Human Brain Mapping

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The primary auditory cortex (PAC) is located in the region of Heschl's gyrus (HG), as confirmed by histological, cytoarchitectonical, and neurofunctional studies. Applying cortical thickness (CTH) analysis based on high‐resolution magnetic resonance imaging (MRI) and magnetoencephalography (MEG) in 60 primary school children and 60 adults, we investigated the CTH distribution of left and right auditory cortex (AC) and primary auditory source activity at the group and individual level. Both groups showed contoured regions of reduced auditory cortex (redAC) along the mediolateral extension of HG, illustrating large inter‐individual variability with respect to shape, localization, and lateralization. In the right hemisphere, redAC localized more within the medial portion of HG, extending typically across HG duplications. In the left hemisphere, redAC was distributed significantly more laterally, reaching toward the anterolateral portion of HG. In both hemispheres, redAC was found to be significantly thinner (mean CTH of 2.34 mm) as compared to surrounding areas (2.99 mm). This effect was more dominant in the right hemisphere rather than in the left one. Moreover, localization of the primary component of auditory evoked activity (P1), as measured by MEG in response to complex harmonic sounds, strictly co‐localized with redAC. This structure–function link was found consistently at the group and individual level, suggesting PAC to be represented by areas of reduced cortex in HG. Thus, we propose reduced CTH as an in vivo marker for identifying shape and localization of PAC in the individual brain.

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Cortical thickness of supratemporal plane predicts auditory N1 amplitude

Cited by 28 publications

References 27 publications

Genetic Sources of Subcomponents of Event-Related Potential in the Dimension of Psychosis Analyzed From the B-SNIP Study

Genetic Sources of Subcomponents of Event-Related Potential in the Dimension of Psychosis Analyzed From the B-SNIP Study

Developmental and cross-modal plasticity in deafness: Evidence from the P1 and N1 event related potentials in cochlear implanted children

Reduced cortical thickness in Heschl's gyrus as an in vivo marker for human primary auditory cortex

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