Cortical thickness, gray matter volume and cognitive performance: a cross-sectional study of the moderating effects of age on their inter-relationships
Abstract:In a sample comprising younger, middle-aged and older cognitively healthy adults (N = 375), we examined associations between mean cortical thickness, gray matter volume (GMV) and performance in four cognitive domains - memory, speed, fluency and crystallized intelligence. In almost all cases, the associations were moderated significantly by age, with the strongest associations in the older age group. An exception to this pattern was identified in a younger adult sub-group aged less than 23 yrs, when a negative… Show more
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