Cortical-subcortical structural connections support transcranial magnetic stimulation engagement of the amygdala

Sydnor, Valerie J.; Cieslak, Matthew; Duprat, Romain; Deluisi, Joseph; Flounders, Matthew W.; Long, Haixia; Scully, Morgan; Balderston, Nicholas L.; Sheline, Yvette I.; Bassett, Dani S.; Satterthwaite, Theodore D.; Oathes, Desmond J.

doi:10.1101/2021.11.12.468411

Cited by 5 publications

(4 citation statements)

References 96 publications

(224 reference statements)

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“…We envision that these results may contribute to the design of brain stimulation paradigms that—beyond maps of direct connectivity—also leverage knowledge of network communication dynamics [63]. For example, models of polysynaptic transmission could inform the selection of stimulation sites for indirect modulation of deep gray matter structures by non-invasive techniques, such as transcranial magnetic stimulation [64, 65].…”

Section: Discussionmentioning

confidence: 99%

Communication dynamics in the human connectome shape the cortex-wide propagation of direct electrical stimulation

Seguin

Jedynak

David

et al. 2022

Preprint

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Communication between gray matter regions underpins all facets of brain function. To date, progress in understanding large-scale neural communication has been hampered by the inability of current neuroimaging techniques to track signaling at whole-brain, high-spatiotemporal resolution. Here, we use 2.77 million intracranial EEG recordings, acquired following 29,055 single-pulse electrical stimulations in a total of 550 individuals, to study inter-areal communication in the human brain. We found that network communication models---computed on structural connectivity inferred from diffusion MRI---can explain the propagation of direct, focal electrical stimulation through white matter, measured at millisecond time scales. Building on this finding, we show that a parsimonious statistical model comprising structural, functional and spatial factors can accurately and robustly predict cortex-wide effects of brain stimulation (out-of-sample R2=54%). Our work contributes towards the biological validation of concepts in network neuroscience and provides insight into how white matter connectivity shapes inter-areal signaling. We anticipate that our findings will have implications for research on macroscale neural information processing and the design of brain stimulation paradigms.

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Section: Discussionmentioning

confidence: 99%

Communication dynamics in the human connectome shape the cortex-wide propagation of direct electrical stimulation

Seguin

Jedynak

David

et al. 2022

Preprint

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“…The main mechanism of action proposed for rTMS in SUD treatment is to activate dopamine function in meso-cortico-limbic system and a reinstaining of extracellular glutamate and dopamine concentrations, which could trigger changes of dendritic spine density, neurotransmitter receptor expression, neuronal degeneration, and microglial activation which could explain the microstructural reversive results in basal ganglia and PFC (8,51,52). A previous study has found that rTMS can reach deep subcortical structures such as the amygdala through stimulation of cortical to subcortical connections (53). Our electric-field simulations show that active rTMS in patients with CUD may have reached deep structures reflected by changes in NODDI metrics.…”

Section: Discussionmentioning

confidence: 99%

Cortical and subcortical connections change after repetitive transcranial magnetic stimulation therapy in cocaine use disorder and predict clinical outcome

Rasgado-Toledo

Issa-Garcia

Alcalá-Lozano

et al. 2022

Preprint

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Cocaine use disorder (CUD) is a worldwide public health condition which is suggested to induce pathological changes in macro- and microstructure. Treatments with psychosocial and pharmacological approaches achieve only low to moderate effects on dealing with cocaine clinical symptomatology. Novel approaches such as repetitive transcranial magnetic stimulation (rTMS) have gained attention to induce a reduction in CUD symptoms, yet its mechanisms remain partially understood. Here, we sought to elucidate whether rTMS induces changes on white matter (WM) microstructure in frontostriatal circuits after two weeks of therapy in patients with CUD, and to test whether baseline WM microstructure of the same circuits has an effect on clinical improvement. This study consisted of a 2-week, parallel group, double-blind, randomized controlled clinical trial (acute phase) (sham [n = 23] and active [n = 27]), in which patients received two daily sessions of rTMS on the left dorsolateral prefrontal cortex (lDLPFC) as an add-on treatment. We acquired T1-weighted and HARDI-DWI 2-shell sequences at baseline and at two weeks. To elucidate the effects from active rTMS on frontostriatal WM tracts, we extracted NODDI metrics and performed a linear mixed model. We further evaluated the relationship between clinical outcomes in craving and impulsivity and the baseline white matter microstructure. After 2 weeks, active rTMS showed a significant increase in neurite density (ICVF or the density of axons and dendrites) compared to sham rTMS in WM tracts connecting left DLPFC with left (B = 0.038, d = -0.278) and right vmPFC (B = 0.034, d = -0.112). Similarly, rTMS showed reduction in orientation dispersion (OD or axon organization) in WM tracts connecting left DLPFC with left caudate nucleus (B = 0.009, d = -0.087), left thalamus (B = 0.006, d = -0.489) and left vmPFC (B = 0.027, d = 0.024). Results also show a greater reduction in craving VAS after 2 weeks rTMS when baseline ICVF was low in WM tracts connecting left caudate nucleus with substantia nigra (B = 22.61, d = 0.729), left pallidum (B = 21.13, d = 0.738), and those connecting left thalamus with substantia nigra (B = 16.30, d = 0.649) and left pallidum (B = 21.92, d = 0.723). Our results suggest that rTMS induced white matter microstructural changes between fronto-striato-thalamic regions after 2 weeks. rTMS-induced microstructural changes may depend on the baseline integrity of the connections between the striatum, thalamus, and the substantia nigra. Connections that predicted clinical improvement in CUD. The current results support the efficacy of rTMS as a therapeutic tool in the treatment of CUD. However, the individual clinical improvement may rely on each patient state of structural connections integrity. Keywords: Cocaine use disorder; Imaging; Transcranial magnetic stimulation; Diffusion MRI; NODDI

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“…Another human study using multiple sites found that the abnormal intrinsic and extrinsic circuits of the striatum provided a robust neuroimaging biomarker for the diagnosis of schizophrenia 63 . The identified heterogeneous connections between specific brain regions provide potential targets for treatments 64 and neuromodulations 65 . In addition, whole-brain connections allow for graph theory to be used to identify the functional subsystem of the brain and the network properties 66 .…”

Section: Macaque Brainnetome Atlas: Parcellation and Connectionmentioning

confidence: 99%

Macaque Brainnetome Atlas: A Multifaceted Brain Map with Parcellation, Connection, and Histology

Cui

Cao

et al. 2022

Preprint

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The rhesus macaque (Macaca mulatta) is a crucial experimental animal that shares many genetic, brain organizational, and behavioral characteristics with humans. A macaque brain atlas that identifies anatomically and functionally distinct regions is fundamental to biomedical and evolutionary research. However, even though connectivity information is vital for understanding brain functions, a connectivity-based whole-brain atlas of the macaque has not previously been made. In this study, we created a new whole-brain map, the Macaque Brainnetome Atlas, based on the anatomical connectivity profile provided by high-resolution angular and spatial diffusion MRI data. The new atlas consists of 248 cortical and 56 subcortical regions as well as their structural and resting-state functional connections. We systematically evaluated the parcellations and connections using multi-site and multi-modal datasets to ensure reproducibility and reliability. The resulting resource, which is downloadable fromhttp://atlas.brainnetome.org, includes (1) the thoroughly delineated Macaque Brainnetome Atlas (MacBNA), (2) the multi-modal connections, (3) the largest postmortem high resolution macaque dMRI dataset, and (4) ex vivo MRI, block-face, and Nissl-stained images obtained from a different macaque. We provide an exemplar use of the resource with a joint multi-modal and multi-scale utilization of MRI and Nissl data with our atlas as a reference system. The goals of the resource are not only to provide a backbone of the mesoscopic connectivity and a multi-omics (such as transcriptomes and proteomes) atlas but also to facilitate translational medicine, cross-species comparisons, and computational modelling, enriching the collaborative resource platform of nonhuman primate data.

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Cortical-subcortical structural connections support transcranial magnetic stimulation engagement of the amygdala

Cited by 5 publications

References 96 publications

Communication dynamics in the human connectome shape the cortex-wide propagation of direct electrical stimulation

Communication dynamics in the human connectome shape the cortex-wide propagation of direct electrical stimulation

Cortical and subcortical connections change after repetitive transcranial magnetic stimulation therapy in cocaine use disorder and predict clinical outcome

Macaque Brainnetome Atlas: A Multifaceted Brain Map with Parcellation, Connection, and Histology

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